THAM administration reduces pulmonary carbon dioxide elimination in hypercapnia – an experimental porcine study

Höstman, Staffan; Kawati, Rafael; Perchiazzi, Gaetano; Larsson, Anders

doi:10.1111/aas.13097

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How To Manage Hypercapnia1

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“…The use of tris-hydroxymethyl aminomethane may be helpful to buffer HA by buffering cell pH and reducing CO 2 levels. It may also mitigate the adverse effects of acidosis on the cardiovascular system and restore hemodynamic stability [ 83 ]. Further studies are required to standardize its use since it does not solve the problem of nonperfused regions of the lung.…”

Section: How To Manage Hypercapniamentioning

confidence: 99%

Hypercapnia from Physiology to Practice

Almanza‐Hurtado

Guerra

Martínez‐Ávila³

et al. 2022

International Journal of Clinical Practice

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Acute hypercapnic ventilatory failure is becoming more frequent in critically ill patients. Hypercapnia is the elevation in the partial pressure of carbon dioxide (PaCO2) above 45 mmHg in the bloodstream. The pathophysiological mechanisms of hypercapnia include the decrease in minute volume, an increase in dead space, or an increase in carbon dioxide (CO2) production per sec. They generate a compromise at the cardiovascular, cerebral, metabolic, and respiratory levels with a high burden of morbidity and mortality. It is essential to know the triggers to provide therapy directed at the primary cause and avoid possible complications.

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Section: How To Manage Hypercapniamentioning

confidence: 99%