Thallium-201 uptake relates to membrane potential and potassium permeability in human glioma cells

Brismar, Tom; Vp, Collins; Kesselberg, M.

doi:10.1016/0006-8993(89)90296-5

Cited by 82 publications

(21 citation statements)

References 16 publications

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“…201 Tl (thallous chloride), a radioisotope, is a potassium analogue. Tumor cells, which have a high rate of metabolic activity, accumulate more Tl (via active transport) than does surrounding normal tissue [129][130][131][132].…”

Section: Thallium-201 Single-photon Emission Ct (Spect)mentioning

confidence: 99%

Focal Neurological Disease in Patients with Acquired Immunodeficiency Syndrome

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2002

Clinical Infectious Diseases

141

128

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Focal neurological disease in patients with acquired immunodeficiency syndrome may be caused by various opportunistic pathogens and malignancies, including Toxoplasma gondii, progressive multifocal leukoencephalopathy (PML), cytomegalovirus (CMV), and Epstein-Barr virus-related primary central nervous system (CNS) lymphoma. Diagnosis may be difficult, because the findings of lumbar puncture, computed tomography (CT), and magnetic resonance imaging are relatively nonspecific. Newer techniques have led to improved diagnostic accuracy of these conditions. Polymerase chain reaction (PCR) of cerebrospinal fluid specimens is useful for diagnosis of PML, CNS lymphoma, and CMV encephalitis. Recent studies have indicated the diagnostic utility of new neuroimaging techniques, such as single-photon emission CT and positron emission tomography. The combination of PCR and neuroimaging techniques may obviate the need for brain biopsy in selected cases. However, stereotactic brain biopsy, which is associated with relatively low morbidity rates, remains the reference standard for diagnosis. Highly active antiretroviral therapy has improved the prognosis of several focal CNS processes, most notably toxoplasmosis, PML, and CMV encephalitis.

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Section: Thallium-201 Single-photon Emission Ct (Spect)mentioning

confidence: 99%

Focal Neurological Disease in Patients with Acquired Immunodeficiency Syndrome

Skiest

2002

Clinical Infectious Diseases

141

128

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“…Concerning the mechanisms of TI uptake, many theories, such as increasing blood flow, 9 sodium-potassium ATPase activation, 10 '' 1 tumor viability and increased cell membrane potential 12 and others have been proposed. TI accumulation in inflammatory or benign lesions decreases with time, but prolonged retention of radioactivity with delayed washout has been observed in malignant tumors.…”

Section: Discussionmentioning

confidence: 99%

Thallium and FDG uptake by atelectasis with bronchogenic carcinoma

et al. 1999

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We report a case of bronchogenic carcinoma with atelectasis studied by T1-SPECT and FDG-PET. In the carcinoma, abnormally high uptake of T1 and FDG were detected, but in the region of atelectasis, an abnormally high uptake of T1 with a relatively low uptake of FDG were observed. On quantitative analyses, the T1 retention indexes of the tumor and atelectasis were 29.7 and 42.0. The mean SUVs of FDG of the tumor and the atelectasis were 8.92 and 1.28. T1-SPECT could not distinguish the atelectasis from the carcinoma. FDG-PET was superior to T1-SPECT in this case in detecting malignancy and distinguishing it from atelectasis.

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“…Several studies suggested a correlation between tumour uptake and membrane potential [27][28][29]. Takekawa et al [26] suggested a relationship between 201 Tl uptake and tumour viability.…”

Section: Introductionmentioning

confidence: 99%