Thallium-201 stress scintigraphy in Takayasu arteritis

Hashimoto, Yuji; Numano, Fujío; Maruyama, Yoshihiro; Oniki, Toshiyuki; Kasuya, Kenji; Kakuta, Tsunekazu; Wada, Tomoko; Yajima, Michiyoshi; Maezawa, Hidenori

doi:10.1016/0002-9149(91)90623-s

Cited by 26 publications

(12 citation statements)

References 16 publications

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“…It is very interesting that concentric hypertrophy was demonstrated even if severe aortic regurgitation was present [13]. Using stress thallium-201 myocardial scintigraphy, we reported recently that left ventricular hypertrophy and myocardial damage correlate in patients with Takayasu arteritis [14]. Increased pressure overload (systemic hypertension and stenotic changes of the aorta and/or its major branches) are thought to cause this left ventricular hypertrophy in patients with arteritis and severe aortic regurgitation [15].…”

Section: Discussionmentioning

confidence: 99%

Aortic regurgitation in patients with Takayasu arteritis: Assessment by color Doppler echocardiography

et al. 1992

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To characterize aortic regurgitation in patients with Takayasu arteritis, we studied 48 females with arteritis (mean age 47 +/- 12 years) by means of color Doppler echocardiography. Aortic regurgitation was confirmed in 32 out of 48 patients (67%) by color-flow mapping. Twenty-four patients had mild or no aortic regurgitation (group A), 9 had moderate (group B), and 15 had severe (group C) aortic regurgitation. We compared the echocardiographic data obtained from patients with Takayasu arteritis with those of 14 normal controls and 9 patients with severe aortic regurgitation of valvular origins (group V). The aortic root diameter (AOD) in group B (23 +/- 4 mm/M2) and group C (22 +/- 3 mm/M2) revealed a statistically significant large value as compared with that in group A (18 +/- 2 mm/M2) and normal controls (17 +/- 3 mm/M2). However, the differences, between groups B and C and groups C and V, were not significant. The AOD was not obviously dilated in a considerable number of group C patients. Aortic valve involvement was seen in several group C patients and moderate concentric left ventricular hypertrophy was present in all group C patients. Group C patients therefore, have concentric left ventricular hypertrophy but may or may not have dilatation of the aortic root which can be detected on echocardiography. We conclude that aortic valve involvement may cause aortic regurgitation in some patients with Takayasu arteritis and that aortic regurgitation is more common than previously believed.

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Section: Discussionmentioning

confidence: 99%

Aortic regurgitation in patients with Takayasu arteritis: Assessment by color Doppler echocardiography

et al. 1992

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“…We reported recently that 20 (53%) of the 38 patients with TA evaluated showed abnor mal scintigraphic findings and a high preva lence of complicated AR and LV hypertrophy [11]. Their prognosis is poor when cardiac involvement is severe [2].…”

Section: Discussionmentioning

confidence: 97%

Left Ventricular Geometry in Takayasu Arteritis Complicated by Severe Aortic Regurgitation

Hashimoto

Numano²,

Oniki³

et al. 1992

Cardiology

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Although it has been reported that the aortic regurgitation (AR) of patients with Takayasu arteritis is due to dilatation of the aortic ring, the geometry of the left ventricle (LV) has not been described. We compared the cardiac findings in patients with Takayasu arteritis (TA) and severe AR with those of patients having severe AR of other origins. Echocardiographi-cally, wall thickness (WT) and the concentric hypertrophic ratio (WT/WT + left ventricular enddiastolic dimension) were greater in patients with TA. It is concluded that the LV of the TA patients revealed concentric hypertrophy even when AR was severe.

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“…Hashimoto et al [12] previously reported the prevalence and pathophysiology of the abnormalities observed by means of Tl-201 stress myocardial scintigraphy in 38 patients with Takayasu arteritis. They found that 20 of the 38 patients (53%) had perfusion abnormalities which were responsible for a decrease in coronary reserve, myocardial damage, or both, due to long-standing systemic hypertension or to aortic regurgitation.…”

Section: Discussionmentioning

confidence: 99%

Left ventricular dysfunction and HLA Bw52 antigen in Takayasu arteritis

1992

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Heart disease is the main cause of death in patients with Takayasu arteritis. It has been reported that this disease is closely related to the presence of HLA Bw52 antigen. To assess the correlation between this antigen and left ventricular involvement, we studied 40 patients with Takayasu arteritis, 21 with and 19 without Bw52, using Tl-201 stress myocardial scintigraphy and echocardiography. Those with Bw52 had a significantly higher incidence of abnormal electrocardiographic findings (67% vs 26%; P < 0.05) and of aortic regurgitation (52% vs 11%; P < 0.05). The echocardiographically determined interventricular septal wall thickness plus left ventricular posterior wall thickness (25 +/- 8 vs 17 +/- 3 mm; P < 0.01) and the left ventricular mass (257 +/- 132 vs 142 +/- 51 g; P < 0.01) were significantly increased in the patients with Bw52. Scintigraphically determined perfusion abnormalities were significantly more frequent in those with Bw52 (76% vs 32%; P < 0.05). These observations indicate that patients with Takayasu arteritis and Bw52 antigen have a more severe left ventricular involvement than the patients without that antigen. The left ventricular impairment may account for the poor prognosis of Takayasu patients with Bw52.

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Thallium-201 stress scintigraphy in Takayasu arteritis

Cited by 26 publications

References 16 publications

Aortic regurgitation in patients with Takayasu arteritis: Assessment by color Doppler echocardiography

Aortic regurgitation in patients with Takayasu arteritis: Assessment by color Doppler echocardiography

Left Ventricular Geometry in Takayasu Arteritis Complicated by Severe Aortic Regurgitation

Left ventricular dysfunction and HLA Bw52 antigen in Takayasu arteritis

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