Thalidomide modulates renal inflammation induced by brain death experimental model

Santana, Alexandre Chagas; Andraus, Wellington; Silva, Filipe Miranda Oliveira; Sala, Ana Clara Garcia; Schust, Amanda Souza; Neri, Luís Henrique Metelmann; Feliciano, Regiane dos Santos; Pepineli, Rafael; Dellê, Humberto; Ruiz, Luciana da Silva; Oliveira-Braga, Karina Andrighetti de; Nepomuceno, Natalia Aparecida; Pêgo‐Fernandes, Paulo Manuel; Santos, Marcelo José dos; Moraes, Edvaldo Leal de; Brasil, Sérgio; Figueiredo, Eberval Gadelha

doi:10.1016/j.trim.2022.101710

Cited by 2 publications

(1 citation statement)

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“…In the kidney, we showed that thalidomide acted via a reduction in TNF-α and IL-6 levels. All of these acts to significantly inhibit the immunological response and immunogenicity of the graft 23 , 24 .…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory effect of thalidomide in an experimental lung donor model of brain death

Sana Vilela,

Andrighetti de Oliveira Braga,

Moreira Ruiz

et al. 2024

Sci Rep

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Lung transplantation stands as a vital treatment for severe lung diseases, primarily sourcing organs from donors with brain death (BD). This research delved into the potential anti-inflammatory effects of thalidomide in rats with BD-induced lung complications. In this study twenty-four Wistar rats were divided into three groups: the control (CTR), brain death (BD) and brain death + thalidomide (TLD) groups. Post specific procedures, a 360 min monitoring period ensued. Comprehensive analyses of blood and heart-lung samples were conducted. Elevated IL-6 levels characterized both BD and TLD groups relative to the CTR (p = 0.0067 and p = 0.0137). Furthermore, TNF-α levels were notably higher in the BD group than both CTR and TLD (p = 0.0152 and p = 0.0495). Additionally, IL-1β concentrations were significantly pronounced in both BD and TLD compared to CTR, with the BD group surpassing TLD (p = 0.0256). Immunohistochemical assessments revealed augmented NF-ĸB expression in the BD group in comparison to both CTR and TLD (p = 0.0006 and p = 0.0005). With this study we can conclude that BD induced acute pulmonary inflammation, whereas thalidomide manifested a notable capability in diminishing key inflammatory markers, indicating its prospective therapeutic significance in lung transplantation scenarios.

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Section: Discussionmentioning

confidence: 99%