Thalidomide-induced bronchiolitis obliterans organizing pneumonia in a patient with multiple myeloma

Ati, Z. El; Raîs, L.; Chérif, J.; Jbali, H.; Fatma, L. Ben; Mami, I.; Khedher, R.; Smaoui, W.; Krid, M.; Hamida, F. Ben; Boussaid, S.; Zouaghi, Mohamed Karim

doi:10.4103/1319-2442.265477

Cited by 4 publications

(1 citation statement)

References 14 publications

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“…Several published studies (36)(37)(38)(39) have shown that thalidomide has a certain therapeutic effect on liver, kidney, lung and other organ fibrosis. Previous study has found that thalidomide can increase the overall clinical treatment efficiency, reduce the lesion region in the chest CT and improved the lung function in elderly patients with pulmonary fibrosis (40).…”

Section: Discussionmentioning

confidence: 99%

Thalidomide inhibits the gene promoter of connective tissue growth factor in human embryonic lung fibroblasts

Wu¹,

Liu²,

Zhang³

et al. 2020

Ann Palliat Med

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Background: The etiology and pathogenesis of idiopathic pulmonary fibrosis (IPF) remain unclear, and the early detection and treatment are vital to the prognosis of IPF patients. It's necessary to investigate the effect of thalidomide on the gene promoter activation of connective tissue growth factor (CTGF) induced by transforming growth factor-β1 (TGF-β1) in human embryonic lung fibroblast (HELF). Methods:The gene vector of pGL3-CTGFP containing human CTGF gene promoter was constructed and transfected into HELF cells. We used different TGF-β1 (0, 2.5, 5, 10 and 20 µg/L respectively) to stimulate HELF to identify the optimal concentration for gene promoter of CTGF. The activity of luciferase was measured to observe the effect of TGF-β1 and THALIDOMIDE on the activity of CTGF gene promoter. Results:The relative luciferase activity increased significantly with the stimulation of TGF-β1, and the relative luciferase activity peaked in the 5 µg/L TGF-β1 group (all P<0.01). The thalidomide inhibited the TGF-β1-induced activation of CTGF gene promoter in HELF, and the effect peaked in the 25 µg/L group (all P<0.001).Conclusions: Thalidomide produces a significant inhibitory effect on the gene promoter activation of CTGF induced by TGF-β1 in HELF, it may be a potentially effective drug for the treatment of pulmonary fibrosis.

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Section: Discussionmentioning

confidence: 99%

Thalidomide inhibits the gene promoter of connective tissue growth factor in human embryonic lung fibroblasts

Wu¹,

Liu²,

Zhang³

et al. 2020

Ann Palliat Med

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Thalidomide

2020

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Bronchiolitis and Bronchiolar Disorders

Ravaglia¹,

Poletti

2020

Semin Respir Crit Care Med

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Bronchioles are noncartilaginous small airways with internal diameter of 2 mm or less, located from approximately the eighth generation of purely air conducting airways (membranous bronchioles) down to the terminal bronchioles (the smallest airways without alveoli) and respiratory bronchioles (which communicate directly with alveolar ducts and are in the range of 0.5 mm or less in diameter). Bronchiolar injury, inflammation, and fibrosis may occur in myriad disorders including connective tissue diseases, inflammatory bowel diseases, lung transplant allograft rejection, graft versus host disease in allogeneic stem cell recipients, neuroendocrine cell hyperplasia, infections, drug toxicity (e.g., penicillamine, busulfan), inhalation injury (e.g., cigarette smoke, nylon flock, mineral dusts, hard metals, Sauropus androgynous); idiopathic, common variable immunodeficiency disorder, and a host of other disorders or insults. The spectrum of bronchiolar disorders is wide, ranging from asymptomatic to fatal obliterative bronchiolitis. In this review, we discuss the salient clinical, radiographic, and histological features of these diverse bronchiolar disorders, and discuss a management approach.

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Thalidomide-induced bronchiolitis obliterans organizing pneumonia in a patient with multiple myeloma

Cited by 4 publications

References 14 publications

Thalidomide inhibits the gene promoter of connective tissue growth factor in human embryonic lung fibroblasts

Thalidomide inhibits the gene promoter of connective tissue growth factor in human embryonic lung fibroblasts

Thalidomide

Bronchiolitis and Bronchiolar Disorders

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