Thalidomide for the treatment of hydroa vacciniforme‐like lymphoma: Report of four pediatric cases from Peru

Beltrán, Brady E; Maza, Iván; Moisés-Alfaro, Celia B.; Vásquez, Liliana; Quiñones, Pilar; Morales, Domingo; Sánchez, Gadwin; Paredes, Gloria; Oscanoa, Mónica; Gerónimo, Jenny; Miranda, Roberto N.; Castillo, Jorge J.

doi:10.1002/ajh.23843

Cited by 23 publications

(22 citation statements)

References 7 publications

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“…Hydroa vacciniforme‐like T‐cell lymphoma is an EBV‐associated cutaneous neoplasm that predominantly occurs in East Asian and Latin American children and adolescents (Quintanilla‐Martinez et al , ; Beltran et al , ). Patients present with papulovesicular eruptions with umbilication and crust formation in the sun‐exposed face and upper extremities.…”

Section: Hydroa Vacciniforme‐like T‐cell Lymphomamentioning

confidence: 99%

Mature T‐ and NK‐cell non‐Hodgkin lymphoma in children and young adolescents

et al. 2016

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Mature T/Natural killer (NK)-cell neoplasms of children and the young adolescent population exhibit higher prevalence in Central and South American and Asian populations and many are associated with Epstein-Barr virus (EBV). They are represented in large part by extranodal T/NK cell lymphomas- nasal-type or extra nasal-type, chronic lymphoproliferative disorders of T/NK cells or chronic active EBV disease, systemic EBV-positive lymphoproliferative disorders of childhood, hydroa vacciniforme-like lymphoma, hepatosplenic T-cell lymphoma and primary cutaneous gamma/delta T-cell lymphoma among others. Many T/NK cell neoplasms in this age group are derived from cells of the innate immune system, in contrast to adults where they are predominantly from the adaptive immune system. The genetic basis of T/NK cell lymphomas in children and young adolescents remains largely unknown. Anthracycline-based regimens and haematopoietic stem cell transplants (allogeneic and autologous) are current treatment modalities, however it is anticipated that novel targeted therapeutic agents will be available in the near future.

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Section: Hydroa Vacciniforme‐like T‐cell Lymphomamentioning

confidence: 99%

Mature T‐ and NK‐cell non‐Hodgkin lymphoma in children and young adolescents

et al. 2016

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“…Despite the known possibility of atypical HV evolving to lymphoma, no prognostic clinicopathological features have been identified . Within the pediatric/young adult population, an onset age of >9 years has been reported as one of the poor prognostic factors in EBV‐positive lymphoproliferative disorders . In contrast, Nomura et al .…”

Section: Discussionmentioning

confidence: 99%

“…Several regimens have been reported with moderate and often very variable success. Antiviral agents, interferon gamma, systemic corticosteroids, cyclosporine, intravenous immunoglobulin, and thalidomide have been suggested with variable success.…”

Section: Discussionmentioning

confidence: 99%

“…17 Within the pediatric/young adult population, an onset age of >9 years has been reported as one of the poor prognostic factors in EBV-positive lymphoproliferative disorders. 26,27 In contrast, Nomura et al 5 reported an elderly patient adult patients having HVLPD with anti-inflammatory agents such as minocycline and topical pimecrolimus cream. 6 Our study further demonstrates the utility of topical calcineurin inhibitors in inducing clinical remission.…”

Section: Histopathological Featuresmentioning

confidence: 99%

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Hydroa vacciniforme‐like lymphoproliferative disorder in an elderly Chinese patient and a literature review of adult cases

2018

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Hydroa vaccinforme-like lymphoproliferative disorder (HVLPD) is a rare T-cell lymphoproliferative disorder driven by the Epstein-Barr Virus (EBV). It was initially designated under the 2008 WHO classification of tumors of hematopoietic and lymphoid tissues as a distinct entity but has been recently reclassified as a lymphoproliferative disorder under the 2016 revision of the 2008 WHO classification of lymphoid malignancies. HVLPD mainly affects Asian, Central, and South American children. It is rarely seen in adults. Although HVLPD may initially be limited to cutaneous involvement and run an indolent course, some patients may develop a rapidly aggressive course. We report a case of an elderly Chinese man with cutaneous-limited disease and a favorable course. A review of adult cases of HVLPD published in the English literature, with comparison to our case, is also presented in this paper.

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“…In a report from Peru, 12 patients received different chemotherapy regimens including CHOP with further adjuvant radiotherapy in 4 cases, only 4 patients remained alive, 10 patients died after a mean follow-up of 11.6 months after initial diagnosis because of either concurrent infections, disease progression or both. [ 2 ] In contrast, immunomodulating therapies such as interferon-α, prednisolone, cyclosporine A, and thalidomide have been shown to result in improvement of symptoms, [ 3 , 11 , 12 ] Xu et al [ 3 ] reported a series of 7 Chinese children with HVLL, 4 cases had their skin lesions improved after interferon-α treatment. In the report by Beltrán et al, [ 11 ] 2 out of 4 patients had clinical response to thalidomide, which is a drug with immunomodulatory and antiangiogenic properties.…”

Section: Discussionmentioning

confidence: 99%

Hydroa vacciniforme-like cutaneous T-cell lymphoma in a child

Zan

Liu

et al. 2018

Medicine

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Rationale:Hydroa vacciniforme (HV)-like T-cell lymphoma is a rare malignancy in childhood associated with Epstein-Barr virus infection.Patient concerns:A 6-year old girl presented with complaint of 3-year history of recurrent skin lesions, 3 months of fever accompanied by cough for 8 days.Diagnoses:Skin biopsy revealed a HV-like lymphoma presentation and positive signals of EBER were detected by in situ hybridization. TCR-γ gene monoclonal rearrangement was present. A HV-like cutaneous T-cell lymphoma was diagnosed.Interventions:The girl was treated with cyclosporine and CHOP.Outcomes:The girl's condition had been stable for 6 months.Lessons:Our case highlights the necessity for taking the HV-like lymphoma as a differential diagnosis especially when a patient manifests as recurrent skin lesions accompanied by systemic involvement.

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Thalidomide for the treatment of hydroa vacciniforme‐like lymphoma: Report of four pediatric cases from Peru

Cited by 23 publications

References 7 publications

Mature T‐ and NK‐cell non‐Hodgkin lymphoma in children and young adolescents

Mature T‐ and NK‐cell non‐Hodgkin lymphoma in children and young adolescents

Hydroa vacciniforme‐like lymphoproliferative disorder in an elderly Chinese patient and a literature review of adult cases

Hydroa vacciniforme-like cutaneous T-cell lymphoma in a child

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