Thalidomide Embryopathy

A thalidomide analogue within vitroantiproliferative, antimitotic, and microtubule-stabilizing activities

“…The drug was used extensively for morning sickness during pregnancy until it was found to cause significant fetal abnormalities (1). Thalidomide was never approved in the United States initially because of concerns of peripheral neuropathy and then ultimately because of its teratogenic potential.…”

Anti-tumour effects of transcatheter arterial embolisation administered in combination with thalidomide in a rabbit VX2 liver tumour model

“…The animals were killed 7 days later. outlined on each slice by the consensus of two radiologists and the total number of pixels was multiplied by 1.37 mm 3 . The two radiologists were blinded to the animal group from which the images were derived and to whether the images were obtained before or after treatment [17].…”

“…Because it induced foetus-specific malformations such as limb dysgenesis, it was taken off the market in 1961 [3]. In 1998, thalidomide was approved by the Food and Drug Administration for the treatment of multiple myeloma because it inhibited angiogenesis in carcinoma cells and because a third of patients with end-stage multiple myeloma showed improvement [4,5].…”

Environmental Factors in the Aetiology of Autism – Lessons from Animals Prenatally Exposed to Valproic Acid

“…That was the first study related to autism in which we had a known cause, a set of physical, neurological, and psychiatric autistic symptoms, and identified stage of development when the triggering insult occurred. (Lenz & Knapp, 1962;Miller, 1991).…”