Thalassemic Child Presenting with Anosmia due to COVID-19

Marhaeni, Wulandewi; Wijaya, Andreas Budi; Kusumaningtyas, Prabandari; Mapianto, Rahmawan Sakup

doi:10.1007/s12098-020-03370-4

Cited by 16 publications

(13 citation statements)

References 4 publications

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“…Other ocular manifestations included watery eye discharge, 23 conjunctivitis, 15 and periorbital erythema. 29 Other isolated presentations were also reported, such as anosmia, 13 , 39 ageusia, 39 arthralgia. 13 Full cases description and prevalence rates are described in Table 1 , Table 2 , respectively.…”

Section: Resultsmentioning

confidence: 96%

“… 30 Neurological manifestations were frequently described as neurocognitive symptoms, including headache, irritability, lethargy, and somnolence. 13 , 14 , 15 , 16 , 23 , 24 , 26 , 29 , 31 , 33 Axial hypotonia, 22 generalized hypertonia, 23 and muscular pain 39 indicated the presence of neuromuscular manifestations.…”

Section: Resultsmentioning

confidence: 99%

“… 12 However, due to the outrageous number of infected children, some fatal cases are being reported, associated with extrapulmonary complications, pointing to a need of medical and scientific attention. 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 …”

Section: Introductionmentioning

confidence: 99%

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Extrapulmonary manifestations of COVID-19 in children: a comprehensive review and pathophysiological considerations

Pousa¹,

Mendonça²,

Oliveira³

et al. 2021

Jornal de Pediatria

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Objective The aim of this review was to summarize the most common extrapulmonary manifestations in pediatric patients with COVID-19, as well as to discuss clinical, epidemiological, and pathophysiological aspects of these clinical presentations in children. Source of data An extensive search of literature was performed in order to identify pediatric cases with extrapulmonary manifestations between January 1, 2020 and June 21, 2020. Generic keywords, such as “Novel coronavirus” or “Novel coronavirus 2019” or “2019 nCoV” or “COVID-19” or “SARS-CoV-2” were searched on PubMed database, associated either with age filters or generic pediatric terms. Summary of findings A total of 28 articles, including 199 patients, were considered suitable to review and data extraction. The main findings were summarized in tables. The main non-pulmonary manifestations in pediatric patients, in decreasing order of frequency, were gastrointestinal, renal, cardiovascular, neurological, hematological and lymphatic, cutaneous, hepatic, ocular, olfactory, and gustatory. Multisystem impairment and Kawasaki-like disease were also described. Conclusions Differences in immune response of children and variations of tissue expression of angiotensin converting enzyme 2, the virus receptor, are likely to influence clinical, epidemiological, and pathophysiological patterns of the disease.

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Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Extrapulmonary manifestations of COVID-19 in children: a comprehensive review and pathophysiological considerations

Pousa¹,

Mendonça²,

Oliveira³

et al. 2021

Jornal de Pediatria

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“…Her father had also tested positive for the virus. 8 Taste and smell disorders have mostly been self-reported.…”

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confidence: 99%

An overview of smell and taste problems in paediatric COVID‐19 patients

et al. 2020

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At the start of the COVID-19 pandemic in March 2020, fever and respiratory symptoms were the indications for virus testing in our hospital. As data have continued to accumulate worldwide, gastrointestinal, neurological, cardiovascular, cutaneous and ocular symptoms have been reported for confirmed COVID-19 cases. There have been few case reports on problems with taste and smell in paediatric COVID-19. However, new symptoms can provide diagnostic and testing criteria for patients with no other clinical presentation, especially in older children. Conclusion: This paper looks at the taste and smell problems reported in paediatric patients and shares insights from our hospital.

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“…[ 14 ] reported total loss of smell in three children aged 14, 15 and 17 years, who tested positive for the virus, and two of them also reported changes in taste. Another study reported that a 17-year-old girl with beta-thalassemia, who tested positive for the virus, presented with a total loss of smell and taste for 8 days [ 15 ]. In all these studies the children, who found to have change in smell and taste, were above 14 years of age.…”

Section: Discussionmentioning

confidence: 99%

Paediatric COVID-19: Milder Presentation—A Silver Lining in Dark Cloud

Ramteke

Tikkas

Goel

et al. 2020

Journal of Tropical Pediatrics

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Objective To assess the clinico-epidemiological profile of paediatric patients with Corona virus disease 2019 (COVID-19) infection during the pandemic. Methods Clinico-epidemiological and laboratory profile of children between 1 month and 14 years were studied between 15 May and 31 July 2020, who had positive nasopharyngeal and oropharyngeal swab for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) by reverse transcriptase–polymerase chain reaction (RT-PCR). Results A total of 30 children with median age of 10.5 years (8 months to 14 years) were included in the present study. Sixty percent were boys. Twenty-seven (90%) belonged to an urban area and all 30 children were from a containment area. All were belonging to Kuppuswamy upper lower and lower socioeconomic class. Twenty-one (70%) were asymptomatic. All children had a positive household contact. Symptomatic children had only mild symptoms of fever, dry cough and rhinitis. All were fully vaccinated as per age. Nine (30%) had anaemia. The mean leucocyte count was 7470 ± 2427 (4300–14 100). Leucocytosis was seen in 3 (9%) children. C-reactive protein was found to be raised in only 4 (13%) children. We did not find alteration in sense of smell and taste. No mortality was reported. Conclusion COVID-19 in paediatric patients is usually mild. Severe acute respiratory infection is not a major manifestation of COVID 19 infection in children. All children infected by the novel Corona virus-2 in this study, have a documented household contact.

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Thalassemic Child Presenting with Anosmia due to COVID-19

Cited by 16 publications

References 4 publications

Extrapulmonary manifestations of COVID-19 in children: a comprehensive review and pathophysiological considerations

Extrapulmonary manifestations of COVID-19 in children: a comprehensive review and pathophysiological considerations

An overview of smell and taste problems in paediatric COVID‐19 patients

Paediatric COVID-19: Milder Presentation—A Silver Lining in Dark Cloud

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