Thalassemia minor presenting with vitamin B&lt;sub&gt;12&lt;/sub&gt; deficiency, paraparesis, and microcytosis

Lardhi, Arwa; Ali, Rania Alhaj; Ali, Rola H.; Mohammed, Tarek Salah El-Din

doi:10.2147/jbm.s163722

Cited by 4 publications

(1 citation statement)

References 13 publications

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“…The higher MCV and MCH values here could probably be due to presence of concomitant folate deficiency, which is frequently reported among thalassaemia patients due to chronic erythroid hyperplasia (4). This has also been previously reported among individuals with thalassaemia trait (17).…”

Section: Full Blood Count As An Indicator To Differentiate the Differ...supporting

confidence: 86%

Haematologic Profile of Haemoglobin Constant Spring and Its Co-inheritance With Alpha and Beta Thalassaemia Among Form Four Students in Negeri Sembilan

Nahanthiran¹,

Mustapha²,

Thambiah³

et al. 2022

MJMHS

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Introduction: In Malaysia, the commonest non-deletional alpha (α) thalassaemia is Haemoglobin Constant Spring (Hb CS) which occurs due to a mutation at the termination codon of α2 globin gene (TAA>CAA). Presence of an abnormal peak at Zone 2 on CE or presence of a small peak at c-window on HPLC can be suggestive of Hb CS. The objective of this study was to determine the proportion of form four students diagnosed with Hb CS and to study the haematologic profile of Hb CS and its co-inheritance with α or beta (β) thalassaemia. Methods: This was a cross-sectional study carried out at Hospital Tuanku Ja’afar Seremban (HTJS), involving 15-16 year old secondary school students screened for thalassaemia. The proportion of Hb CS and Hb CS with α or β thalassaemia co-inheritance was calculated and the correlation between the full blood count (FBC) parameters with CE and HPLC results were determined. Results: A total of 3121 students were diagnosed to have thalassaemia and the proportion of Hb CS was 3.24%. Hb CS with α thalassaemia co-inheritance had significantly lower mean corpuscular volume (MCV) compared to Hb CS without co-inheritance and Hb CS with β thalassaemia co-inheritance, t(2)=4.16, p=0.02. This study also has shown that the mean corpuscular haemoglobin (MCH) was significantly lower in Hb CS with α thalassaemia co-inheritance t(2)=9.89, p<0.01. Conclusion: The combination of both, FBC parameters and Hb analysis can be used in screening and in making a presumed diagnosis of Hb CS or co-inheritance with alpha thalassaemia.

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Section: Full Blood Count As An Indicator To Differentiate the Differ...supporting

confidence: 86%