Thalamus: The ‘promoter’ of endogenous modulation of pain and potential therapeutic target in pathological pain

You, Hao-Jun; Lei, Jing; Pertovaara, Antti

doi:10.1016/j.neubiorev.2022.104745

Cited by 21 publications

(11 citation statements)

References 103 publications

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“…These earlier findings on sex-dependent control of heat nociception in healthy animals are only partly similar with the present results on the sex-dependent control of mechanical hypersensitivity in neuropathic animals. The differences between the earlier (Lei et al, 2011) results on heat nociception under physiological conditions and the present results on mechanical hypersensitivity under neuropathic conditions may be explained by differences in the experimental conditions, since descending control of pain-related behavior has been shown to vary from facilitation to inhibition depending on the submodality of test stimulation and pathophysiological condition (Kauppila et al, 1998;You et al, 2022). In neuropathic animals of the present study, CeA inhibition disinhibited spinal α 2 -adrenoceptor-mediated suppression of ongoing-like behavior in a similar fashion in males and females, whereas spinal α 2 -adrenoceptors contributed to the suppression of mechanical hypersensitivity by CeA block in males rather than females.…”

Section: Sexual Dimorphismcontrasting

confidence: 92%

Reduced mechanical hypersensitivity by inhibition of the amygdala in experimental neuropathy: Sexually dimorphic contribution of spinal neurotransmitter receptors

Wang

Chen²,

Lei³

et al. 2022

Brain Research

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Section: Sexual Dimorphismcontrasting

confidence: 92%

Reduced mechanical hypersensitivity by inhibition of the amygdala in experimental neuropathy: Sexually dimorphic contribution of spinal neurotransmitter receptors

Wang

Chen²,

Lei³

et al. 2022

Brain Research

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“…In tandem with the PAG and the amygdala, the thalamus triggers a descending inhibitory pathway that reduces pain (see You et al, for a review). 95 Additionally, the combination of excitatory and inhibitory thalamocortical interactions can dynamically shape large-scale cortical dynamics, which are important for regulating arousal levels in the brain. For example, during sleep there is an increased connectivity between the thalamus and sensorimotor networks.…”

Section: Interoceptive Neural Processingmentioning

confidence: 99%

Interoception in Autism: A Narrative Review of Behavioral and Neurobiological Data

Loureiro,

Ringold,

Aziz-Zadeh

2024

PRBM

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While exteroceptive sensory processing is a hallmark of autism spectrum disorder, how interoceptive processing may impact and contribute to symptomatology remains unclear. In this comprehensive narrative review on interoception in autism, we discuss: 1) difficulties with assessing interoception; 2) potential interoceptive differences; 3) interactions between neural systems for interoception, attention, sensorimotor processing, and cognition; and 4) potential differences in neural circuits involved in interoception. In general, there are mixed findings on potential interoception differences in autism. Nevertheless, some data indicate differences in integration of interoceptive and exteroceptive information may contribute to autism symptomatology. Neurologically, interoceptive processing in autism may be impacted by potential differences in the development, morphometry, and connectivity of key interoceptive hubs (vagal processing, brainstem, thalamus, insula), though much work is needed on this topic.

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“…The EIH effects following exercises of different intensities might be attributed to the mechanisms of endogenous pain modulation (Koltyn et al, 2014 ), which have different activation thresholds for the perception stimulus (You et al, 2022 ). The ventromedial nucleus of the thalamus can be activated by inputs from both noxious and non‐noxious C fibers, which can be triggered via muscle contraction (Adreani et al, 1997 ) and can induce descending inhibition.…”

Section: Introductionmentioning

confidence: 99%

Modulation of pain perceptions following treadmill running with different intensities in females

Zi‐Han,

Nan,

Rui

et al. 2023

Physiological Reports

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We aimed to compare the effects of three intensities of treadmill running on exercise‐induced hypoalgesia (EIH) in healthy individuals. We anticipated that the primary and secondary changes in pain perception and modulation may differ between running intensities. Sixty‐six women were randomly assigned to one of three treadmill running intensities for 35 min: 40% reserved heart rate (HRR), 55% HRR, or 70% HRR. The effects of EIH were assessed using pressure pain thresholds (PPT) and tolerance thresholds (PPTol). We measured conditional pain modulation (CPM). Compared with baseline, PPT and PPTol significantly increased in all groups during running and at the 5–10‐min follow‐up. The PPT and PPTol changes in the moderate‐ and low‐intensity groups were significantly higher than those in the high‐intensity group during running and 24 h after running, while the CPM responses of the high‐intensity group were significantly reduced at the 24‐h follow‐up. Moderate‐ and low‐intensity running may elicit significant primary and secondary (persisting over 24 h) EIH effects and increase CPM responses in females. However, high‐intensity running induced only limited analgesic effects and reduced CPM responses, which may be attributed to the activation of endogenous pain modulation.

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Thalamus: The ‘promoter’ of endogenous modulation of pain and potential therapeutic target in pathological pain

Cited by 21 publications

References 103 publications

Reduced mechanical hypersensitivity by inhibition of the amygdala in experimental neuropathy: Sexually dimorphic contribution of spinal neurotransmitter receptors

Reduced mechanical hypersensitivity by inhibition of the amygdala in experimental neuropathy: Sexually dimorphic contribution of spinal neurotransmitter receptors

Interoception in Autism: A Narrative Review of Behavioral and Neurobiological Data

Modulation of pain perceptions following treadmill running with different intensities in females

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