Thalamus abnormalities during working memory in schizophrenia. An fMRI study

Bor, Julie; Sappey-Marinier, Dominique; Ibarrola, Danielle; d’Amato, Thierry; Suaud-Chagny, Marie-Françoise; Saoud, Mohamed

doi:10.1016/j.schres.2010.10.018

Cited by 33 publications

(19 citation statements)

References 28 publications

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“…Thalamus has dense reciprocal projections with cerebral neocortex and with limbic structures, and forms a key part of the pathway for transmission of sensory information to cortex [35]. The thalamus and the basal ganglia are key structures linked to the prefrontal cortex and are known to be involved in working memory [36] and it also participate in the thalamic–cortical–striatal circuitry subserving working memory [37]. An alternative account of the present findings, which emphasizes the fractional similarity network analysis results, posits the DLPFC/anterior cingulate cortex (ACC)/thalamus triad as a core deficit, with the dysfunction elsewhere in the network as a downstream functional consequence of working memory disturbance [15].…”

Section: Results Of Human Brain Datamentioning

confidence: 99%

Multimodal Fusion With Reference: Searching for Joint Neuromarkers of Working Memory Deficits in Schizophrenia

Calhoun

Erp

et al. 2018

IEEE Trans. Med. Imaging

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Multimodal fusion is an effective approach to take advantage of cross-information among multiple imaging data to better understand brain diseases. However, most current fusion approaches are blind, without adopting any prior information. To date, there is increasing interest to uncover the neurocognitive mapping of specific behavioral measurement on enriched brain imaging data; hence, a supervised, goal-directed model that enables a priori information as a reference to guide multimodal data fusion is in need and a natural option. Here we proposed a fusion with reference model, called “multi-site canonical correlation analysis with reference plus joint independent component analysis” (MCCAR+jICA), which can precisely identify co-varying multimodal imaging patterns closely related to reference information, such as cognitive scores. In a 3-way fusion simulation, the proposed method was compared with its alternatives on estimation accuracy of both target component decomposition and modality linkage detection. MCCAR+jICA outperforms others with higher precision. In human imaging data, working memory performance was utilized as a reference to investigate the covarying functional and structural brain patterns among 3 modalities and how they are impaired in schizophrenia. Two independent cohorts (294 and 83 subjects respectively) were used. Interestingly, similar brain maps were identified between the two cohorts, with substantial overlap in the executive control networks in fMRI, salience network in sMRI, and major white matter tracts in dMRI. These regions have been linked with working memory deficits in schizophrenia in multiple reports, while MCCAR+jICA further verified them in a repeatable, joint manner, demonstrating the potential of such results to identify potential neuromarkers for mental disorders.

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Section: Results Of Human Brain Datamentioning

confidence: 99%

Multimodal Fusion With Reference: Searching for Joint Neuromarkers of Working Memory Deficits in Schizophrenia

Calhoun

Erp

et al. 2018

IEEE Trans. Med. Imaging

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“…Gamma band oscillations are linked with performance of working memory tasks (Yamamoto et al;Howard et al, 2003;Roux and Uhlhaas, 2014), where patients show impairment (Perlstein et al, 2001;Bor et al, 2011). Indeed, the deficits in gamma oscillatory activity in patients are correlated with working memory deficits (Cho et al, 2006).…”

Section: The Trn and Schizophrenia Risk Factors: Preclinical Evidencementioning

confidence: 99%

The thalamic reticular nucleus: A functional hub for thalamocortical network dysfunction in schizophrenia and a target for drug discovery

Pratt

Morris

2015

J Psychopharmacol

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. (2015) The thalamic reticular nucleus: a functional hub for thalamocortical network dysfunction in schizophrenia and a target for drug discovery. Journal of Psychopharmacology. Copyright © 2015 Sage PublicationsA copy can be downloaded for personal non-commercial research or study, without prior permission or charge Content must not be changed in any way or reproduced in any format or medium without the formal permission of the copyright holder(s) The thalamic reticular nucleus -A communication hub AbstractThe thalamus (comprising many distinct nuclei) plays a key role in facilitating sensory discrimination and cognitive processes through connections with the cortex . Impaired thalamocortical processing has long been considered to be involved in schizophrenia. In this review we focus on the thalamic reticular nucleus (TRN) providing evidence for it being an important communication hub between the thalamus and cortex and how it may play a key role in the pathophysiology of schizophrenia. We first highlight the functional neuroanatomy, neurotransmitter localisation and physiology of the TRN. We then present evidence of the physiological roles of the TRN in relation to oscillatory activity, cognition and behaviour. Next we discuss the role of the TRN in rodent models of risk factors for schizophrenia (genetic and pharmacological) and provide evidence for TRN deficits in schizophrenia. Finally we discuss new drug targets for schizophrenia in relation to restoring TRN circuitry dysfunction.

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“…Working memory task-related brain activation is altered, showing mostly increased activation, in several neuropsychiatric disorders, such as schizophrenia (Bor et al, 2011; Callicott et al, 2003b), bipolar disorder (Drapier et al, 2008), and major depressive disorder (Matsuo et al, 2007), as well as the healthy, at-genetic-risk, siblings of patients for some of these disorders (e.g., Callicott et al, 2003a; Drapier et al, 2008; Winterer et al, 2003). These disorders are highly heritable, but their onset and trajectory are thought to be influenced by a large number of genetic polymorphisms, each with a small effect, as well as environmental factors.…”

Section: Introductionmentioning

confidence: 99%

Genome-wide association study of working memory brain activation

Blokland

Wallace

Hansell

et al. 2017

International Journal of Psychophysiology

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In a population-based genome-wide association (GWA) study of n-back working memory task-related brain activation, we extracted the average percent BOLD signal change (2-back minus 0-back) from 46 regions-of-interest (ROIs) in functional MRI scans from 863 healthy twins and siblings. ROIs were obtained by creating spheres around group random effects analysis local maxima, and by thresholding a voxel-based heritability map of working memory brain activation at 50%. Quality control for test-retest reliability and heritability of ROI measures yielded 20 reliable (r>0.7) and heritable (h2>20%) ROIs. For GWA analysis, the cohort was divided into a discovery (n=679) and replication (n=97) sample. No variants survived the stringent multiple-testing-corrected genome-wide significance threshold (p<4.5×10−9), or were replicated (p<0.0016), but several genes were identified that are worthy of further investigation. A search of 529,379 genomic markers resulted in discovery of 31 independent single nucleotide polymorphisms (SNPs) associated with BOLD signal change at a discovery level of p<1×10−5. Two SNPs (rs7917410 and rs7672408) were associated at a significance level of p<1×10−7. Only one, most strongly affecting BOLD signal change in the left supramarginal gyrus (R2=5.5%), had multiple SNPs associated at p<1×10−5 in linkage disequilibrium with it, all located in and around the BANK1 gene. BANK1 encodes a B-cell-specific scaffold protein and has been shown to negatively regulate CD40-mediated AKT activation. AKT is part of the dopamine-signaling pathway, suggesting a mechanism for the involvement of BANK1 in the BOLD response to working memory. Variants identified here may be relevant to (the susceptibility to) common disorders affecting brain function.

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Thalamus abnormalities during working memory in schizophrenia. An fMRI study

Cited by 33 publications

References 28 publications

Multimodal Fusion With Reference: Searching for Joint Neuromarkers of Working Memory Deficits in Schizophrenia

Multimodal Fusion With Reference: Searching for Joint Neuromarkers of Working Memory Deficits in Schizophrenia

The thalamic reticular nucleus: A functional hub for thalamocortical network dysfunction in schizophrenia and a target for drug discovery

Genome-wide association study of working memory brain activation

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