Thalamocortical and Corticothalamic Interaction in the Auditory System

Zhang, Zhuo; Chan, Ying-Shing; He, Jufang

doi:10.1159/000096801

Cited by 3 publications

(5 citation statements)

References 136 publications

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“…5) were generally consistent with current understanding of cortical auditory processing. Our results are consistent with the hypothesis that thalamo-cortical projections transmit auditory information from the thalamus to early auditory cortex, from where cortico-cortical projections relay the results to other perisylvian areas to extract complex auditory features (Zhang et al, 2004; Kumar et al, 2007; Zatorre et al, 2007). Specifically, previous studies have shown that neurons in the medial geniculate nucleus of the thalamus send auditory information to the cortex through projections that terminate in primary auditory cortex (Steriade et al, 1990).…”

Section: Discussionsupporting

confidence: 91%

“…These processes include ECoG modulations in the alpha (8-12 Hz) and high gamma (70-110 Hz) frequency bands. Activity in the alpha band seems to reflect interactions between the thalamus and the cortex (Steriade et al, 1990; Lopes Da Silva, 1991; Zhang et al, 2004), and may facilitate information transfer to task-related cortical areas by inhibiting neural activity in task-unrelated areas (Jensen and Mazaheri, 2010). On the other hand, activity in the high gamma band seems to reflect task-related activity of neural populations directly underneath the electrodes (Crone et al, 1998; Miller et al, 2007, 2009; Schalk et al, 2007; Crone et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

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Spatial and temporal relationships of electrocorticographic alpha and gamma activity during auditory processing

et al. 2014

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Neuroimaging approaches have implicated multiple brain sites in musical perception, including the posterior part of the superior temporal gyrus and adjacent perisylvian areas. However, the detailed spatial and temporal relationship of neural signals that support auditory processing is largely unknown. In this study, we applied a novel inter-subject analysis approach to electrophysiological signals recorded from the surface of the brain (electrocorticography (ECoG)) in ten human subjects. This approach allowed us to reliably identify those ECoG features that were related to the processing of a complex auditory stimulus (i.e., continuous piece of music) and to investigate their spatial, temporal, and causal relationships. Our results identified stimulus-related modulations in the alpha (8-12 Hz) and high gamma (70-110 Hz) bands at neuroanatomical locations implicated in auditory processing. Specifically, we identified stimulus-related ECoG modulations in the alpha band in areas adjacent to primary auditory cortex, which are known to receive afferent auditory projections from the thalamus (80 of a total of 15107 tested sites). In contrast, we identified stimulus-related ECoG modulations in the high gamma band not only in areas close to primary auditory cortex but also in other perisylvian areas known to be involved in higher-order auditory processing, and in superior premotor cortex (412/15107 sites). Across all implicated areas, modulations in the high gamma band preceded those in the alpha band by 280 ms, and activity in the high gamma band causally predicted alpha activity, but not vice versa (Granger causality, p < 1e–8). Additionally, detailed analyses using Granger causality identified causal relationships of high gamma activity between distinct locations in early auditory pathways within superior temporal gyrus (STG) and posterior STG, between posterior STG and inferior frontal cortex, and between STG and premotor cortex. Evidence suggests that these relationships reflect direct cortico-cortical connections rather than common driving input from subcortical structures such as the thalamus. In summary, our inter-subject analyses defined the spatial and temporal relationships between music-related brain activity in the alpha and high gamma bands. They provide experimental evidence supporting current theories about the putative mechanisms of alpha and gamma activity, i.e., reflections of thalamo-cortical interactions and local cortical neural activity, respectively, and the results are also in agreement with existing functional models of auditory processing.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Spatial and temporal relationships of electrocorticographic alpha and gamma activity during auditory processing

et al. 2014

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“…Taken together, our results suggest that thalamo- (Zhang et al, 2004;Kumar 266 et al, 2007;Zatorre et al, 2007) (see illustrative yel-267 low arrows in Fig. 4c).…”

supporting

confidence: 66%

“…Activity in the alpha band is thought to represent 62 thalamo-cortical interactions(Steriade et al, 1990; 63 daSilva, 1991;Zhang et al, 2004), whereas activ-64 ity in the high gamma band is believed to index the 65 activity of local population of neurons(Miller et al, 66 2009;Miller, 2010). To extract the time course of al-67 pha and high gamma activity, we filtered ECoG sig-68 nals from each electrode at each specific frequency 69 band using an IIR band-pass filter, and removed spatial 70 noise common to all ECoG electrodes using a com-71 mon average reference (CAR) spatial filter.…”

mentioning

confidence: 99%

Methods for Functional Connectivity Analyses

Schalk¹

2012

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“…The primary and non-primary modules receive unimodal and polymodal sensory inputs, respectively, whereas the association module can integrate sensory inputs of multiple modalities with information related to animal's behavioral states 7,10 . These three modules of sensory thalamus project to the cortex largely in a topographical manner, that is, they preferentially project to the middle layers of the primary, secondary and association sensory cortices 7,[11][12][13] , respectively, although the non-primary and association thalamic neurons may also have axons fibers that extend horizontally in the superficial layer to other cortical areas 7,9,[13][14][15] . These topographically organized thalamocortical pathways serve as essential conduits for sensory integration, perception, and the construction of our conscious experience of the world around us.…”

Section: Introductionmentioning

confidence: 99%

A novel architecture of PT neuron-based corticothalamic connectivity in the auditory system

Xie,

Gao,

Wang

et al. 2023

Preprint

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Largely topographical projections from different modules of the thalamus, such as the primary, secondary and association sensory thalamus, to hierarchically defined cortical areas have been recognized across sensory systems. However, how corticothalamic projections, which are believed to be crucial for the remarkable flexibility and precision exhibited by our sensory systems, are organized remained poorly understood compared with the thalamocortical counterpart. Here we report that, first, the primary auditory thalamus received direct inputs from cortical L5 neurons. Second, in contrast to the robust thalamocortical topography, L5 neurons in each of the primary, secondary and association auditory cortical regions project to each individual module of the auditory thalamus at the macroscale. Third, the association cortex provided the most L5 inputs to all thalamic modules followed by the secondary and primary auditory cortices. Lastly, L5 axon terminals were mainly varicosity-type and evenly distributed across thalamic modules, but those in the polymodal association module were the largest. Our data suggest that all the modules of the auditory thalamus may be under the modulation of common L5 inputs. This fully-connected-like corticothalamic architecture urges a revision of the traditional hierarchical model in the sensory systems.

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Thalamocortical and Corticothalamic Interaction in the Auditory System

Cited by 3 publications

References 136 publications

Spatial and temporal relationships of electrocorticographic alpha and gamma activity during auditory processing

Spatial and temporal relationships of electrocorticographic alpha and gamma activity during auditory processing

Methods for Functional Connectivity Analyses

A novel architecture of PT neuron-based corticothalamic connectivity in the auditory system

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