Thalamic single‐unit and local field potential activity in Tourette syndrome

Marceglia, Sara; Servello, Domenico; Foffani, Guglielmo; Porta, Mauro; Sassi, Marco; Mrakic‐Sposta, Simona; Rosa, Manuela; Barbieri, S.; Priori, Alberto

doi:10.1002/mds.22982

Cited by 80 publications

(55 citation statements)

References 46 publications

(56 reference statements)

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“…The present findings may also be of potential clinical interest as deep brain stimulation (DBS) in nearby thalamic regions has recently been used for the treatment of Tourette's syndrome (Servello et al, 2008(Servello et al, , 2009). It will be important to see whether and how the impaired performance monitoring in this disorder (Johannes et al, 2002;Müller et al, 2003), reflected in increased ERN amplitudes, is modulated by DBS in the thalamus; moreover, the implantation of depth electrodes may allow direct recording of electrical activity in these regions (Marceglia et al, 2010) and link it to performance monitoring and other cognitive functions.…”

Section: Discussionmentioning

confidence: 99%

Thalamocingulate Interactions In Performance Monitoring

Seifert¹,

Cramon²,

Imperati³

et al. 2011

J. Neurosci.

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Performance monitoring is an essential prerequisite of successful goal-directed behavior. Research of the last two decades implicates the anterior midcingulate cortex (aMCC) in the human medial frontal cortex and frontostriatal basal ganglia circuits in this function. Here, we addressed the function of the thalamus in detecting errors and adjusting behavior accordingly. Using diffusion-based tractography, we found that, among the thalamic nuclei, the ventral anterior (VA) and ventral lateral anterior (VLa) nuclei have the relatively strongest connectivity with the aMCC. Patients with focal thalamic lesions showed diminished error-related negativity, behavioral error detection, and posterror adjustments. When the lesions specifically affected the thalamic VA/VLa nuclei, these effects were significantly pronounced, which was reflected by the complete absence of the error-related negativity. These results reveal that the thalamus, particularly its VA/VLa region, is a necessary constituent of the performance-monitoring network, anatomically well connected and functionally closely interacting with the aMCC.

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Section: Discussionmentioning

confidence: 99%

Thalamocingulate Interactions In Performance Monitoring

Seifert¹,

Cramon²,

Imperati³

et al. 2011

J. Neurosci.

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“…254 The majority of studies constitute Class IV evidence in the form of case reports 2,4,21,159,263,289 or small case series, 123,199,224,247,256 with many containing previously reported patients. 149,183,225,257,290 Reported outcomes are variable, with 1 report of worsening tic behavior with stimulation, 60 and some series reporting 100% reduction in tic frequency. 146,285 Three studies meet Class III evidentiary criteria, with a total of 16 patients who showed 50%, 3 44%, 172 and 19% 214 mean improvement in Yale Global Tic Severity Score (YGTSS).…”

Section: Centromedian-parafascicular Thalamic Complexmentioning

confidence: 99%

Deep brain stimulation for psychiatric disorders: where we are now

Cleary

Ozpinar

Raslan

et al. 2015

FOC

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Fossil records showing trephination in the Stone Age provide evidence that humans have sought to influence the mind through physical means since before the historical record. Attempts to treat psychiatric disease via neurosurgical means in the 20th century provided some intriguing initial results. However, the indiscriminate application of these treatments, lack of rigorous evaluation of the results, and the side effects of ablative, irreversible procedures resulted in a backlash against brain surgery for psychiatric disorders that continues to this day. With the advent of psychotropic medications, interest in invasive procedures for organic brain disease waned. Diagnosis and classification of psychiatric diseases has improved, due to a better understanding of psychiatric patho-physiology and the development of disease and treatment biomarkers. Meanwhile, a significant percentage of patients remain refractory to multiple modes of treatment, and psychiatric disease remains the number one cause of disability in the world. These data, along with the safe and efficacious application of deep brain stimulation (DBS) for movement disorders, in principle a reversible process, is rekindling interest in the surgical treatment of psychiatric disorders with stimulation of deep brain sites involved in emotional and behavioral circuitry. This review presents a brief history of psychosurgery and summarizes the development of DBS for psychiatric disease, reviewing the available evidence for the current application of DBS for disorders of the mind.

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“…During surgery, neuronal activity of single units can be examined with microelectrode recording (Shields et al, 2008;Zhuang et al, 2009;Alam et al, 2014). After surgery, when the leads of the implanted probe are externalized and before implantation of the pulse generator, local field potentials (LFPs) of neuronal assemblies can be detected (Marceglia et al, 2010).…”

Section: Introductionmentioning

confidence: 99%