Thalamic processing of vibrissal information in the rat. I. Afferent input to the medial ventral posterior and posterior nuclei

Chiaia, Nicolas L.; Rhoades, Robert W.; Bennett‐Clarke, Carol A.; Fish, Stephen E.; Killackey, Herbert P.

doi:10.1002/cne.903140202

Cited by 121 publications

(95 citation statements)

References 38 publications

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“…Consistent with a previous report (Deschenes et al 1998), inspection of the thalamus revealed large numbers of BDA- labeled fibers originating from POm that traversed the VPM en route to the DLS and cortex. In addition, we also observed retrogradely labeled neurons in the interpolaris and other spinal trigeminal nuclei, which is consistent with tracer injections in the POm (Chiaia et al 1991;Peschanski 1984).…”

Section: Resultssupporting

confidence: 88%

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Thalamic POm projections to the dorsolateral striatum of rats: potential pathway for mediating stimulus–response associations for sensorimotor habits

Smith

Mowery

Alloway

2012

Journal of Neurophysiology

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The dorsolateral part of the striatum (DLS) represents the initial stage for processing sensorimotor information in the basal ganglia. Although the DLS receives much of its input from the primary somatosensory (SI) cortex, peripheral somesthetic stimulation activates the DLS at latencies that are shorter than the response latencies recorded in the SI cortex. To identify the subcortical regions that transmit somesthetic information directly to the DLS, we deposited small quantities of retrograde tracers at DLS sites that displayed consistent time-locked responses to controlled whisker stimulation. The neurons that were retrogradely labeled by these injections were located mainly in the sensorimotor cortex and, to a lesser degree, in the amygdala and thalamus. Quantitative analysis of neuronal labeling in the thalamus indicated that the strongest thalamic input to the whisker-sensitive part of the DLS originates from the medial posterior nucleus (POm), a somesthetic-related region that receives inputs from the spinal trigeminal nucleus. Anterograde tracer injections in POm confirmed that this thalamic region projects to the DLS neuropil. In subsequent experiments, simultaneous recordings from POm and the DLS during whisker stimulation showed that POm consistently responds before the DLS. These results suggest that POm could transmit somesthetic information to the DLS, and this modality-specific thalamostriatal pathway may cooperate with the thalamostriatal projections that originate from the intralaminar nuclei.

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Section: Resultssupporting

confidence: 88%

“…Both POm and VPM process somesthetic information received from the trigeminal nuclei (Chiaia et al 1991;Peschanski 1984;Timofeeva et al 2004;Veinante et al 2000a). Consequently, either of these thalamic nuclei could transmit whisker-related information directly to the DLS.…”

Section: Resultsmentioning

confidence: 99%

Thalamic POm projections to the dorsolateral striatum of rats: potential pathway for mediating stimulus–response associations for sensorimotor habits

Smith

Mowery

Alloway

2012

Journal of Neurophysiology

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“…Stimulus-induced correlations were minimized by application of a trial-by-trial shift predictor (Gerstein et al 1989), thus suggesting a common excitatory neural noise source driving VPM correlated activity. The most likely source of these noise-induced VPM correlations is spontaneous excitatory input from principal (PrV) trigeminal nucleus projections or spinal trigeminal nucleus (SpV) projections to VPM thalamus (Chiaia et al 1991;Friedberg et al 2004;Timofeeva et al 2004;Wang and Ohara 1993). Other well described circuit mechanisms could also produce noise correlations among VPM neurons including descending projections from the BF cortex (Bal et al 1995;Bal and McCormick 1996;Friedberg et al 2004;Harris 2005;Lampl et al 1999;Nicolelis et al 1995;Ritz and Sejnowski 1997;Singer 1999).…”

Section: Heterogeneity Of Effects On Target Neuronsmentioning

confidence: 99%

Phasic and Tonic Patterns of Locus Coeruleus Output Differentially Modulate Sensory Network Function in the Awake Rat

Devilbiss

Waterhouse

2011

Journal of Neurophysiology

109

100

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Devilbiss DM, Waterhouse BD. Phasic and tonic patterns of locus coeruleus output differentially modulate sensory network function in the awake rat. J Neurophysiol 105: 69 -87, 2011. First published October 27, 2010 doi:10.1152/jn.00445.2010. Neurons of the nucleus locus coeruleus (LC) discharge with phasic bursts of activity superimposed on highly regular tonic discharge rates. Phasic bursts are elicited by bottom-up input mechanisms involving novel/salient sensory stimuli and top-down decision making processes; whereas tonic rates largely fluctuate according to arousal levels and behavioral states. Although it is generally believed that these two modes of activity differentially modulate information processing in LC targets, the unique role of phasic versus tonic LC output on signal processing in cells, circuits, and neural networks of waking animals is not well understood. In the current study, simultaneous recordings of individual neurons within ventral posterior medial thalamus and barrel field cortex of conscious rats provided evidence that each mode of LC output produces a unique modulatory impact on single neuron responsiveness to sensory-driven synaptic input and representations of sensory information across ensembles of simultaneously recorded cells. Each mode of LC activation specifically modulated the relationship between sensory-stimulus intensity and the subsequent responses of individual neurons and neural ensembles. Overall these results indicate that phasic versus tonic modes of LC discharge exert fundamentally different modulatory effects on target neuronal circuits within the rodent trigeminal somatosensory system. As such, each mode of LC output may differentially influence signal processing as a means of optimizing behaviorally relevant neural computations within this sensory network. Likely the ability of the LC system to differentially regulate neural responses and local circuit operations according to behavioral demands extends to other brain regions including those involved in higher cognitive functions.

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“…Moreover, convergent projections from either the principal (PrV) or spinal trigeminal nucleus (SpV) likely provide singular inputs to VPM neurons. For example, both anatomical and electrophysiological studies reveal SpV neurons have large receptive fields and project to PrV and VPM thalamus, thus eliciting responses in VPM neurons from several whiskers (Chiaia et al, 1991;Wang and Ohara, 1993;Friedberg et al, 2004;Timofeeva et al, 2004). Additionally, differences in response latencies between PrV (ϳ6.7 ms) or SpV (ϳ11 ms) and VPM neurons (Friedberg et al, 2004) could indeed produce the sharp and delayed peaks that were evident in many cross-correlegrams.…”

Section: Dynamic Reorganization Of the Neural Ensemblementioning

confidence: 99%

Locus Ceruleus Regulates Sensory Encoding by Neurons and Networks in Waking Animals

Devilbiss¹,

Page²,

Waterhouse³

2006

J. Neurosci.

101

103

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Substantial evidence indicates that the locus ceruleus (LC)-norepinephrine (NE) projection system regulates behavioral state and statedependent processing of sensory information. Tonic LC discharge (0.1-5.0 Hz) is correlated with levels of arousal and demonstrates an optimal firing rate during good performance in a sustained attention task. In addition, studies have shown that locally applied NE or LC stimulation can modulate the responsiveness of neurons, including those in the thalamus, to nonmonoaminergic synaptic inputs. Many recent investigations further indicate that within sensory relay circuits of the thalamus both general and specific features of sensory information are represented within the collective firing patterns of like-modality neurons. However, no studies have examined the impact of NE or LC output on the discharge properties of ensembles of functionally related cells in intact, conscious animals. Here, we provide evidence linking LC neuronal discharge and NE efflux with LC-mediated modulation of single-neuron and neuronal ensemble representations of sensory stimuli in the ventral posteriomedial thalamus of waking rats. As such, the current study provides evidence that output from the LC across a physiologic range modulates single thalamic neuron responsiveness to synaptic input and representation of sensory information across ensembles of thalamic neurons in a manner that is consistent with the well documented actions of LC output on cognition.

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Thalamic processing of vibrissal information in the rat. I. Afferent input to the medial ventral posterior and posterior nuclei

Cited by 121 publications

References 38 publications

Thalamic POm projections to the dorsolateral striatum of rats: potential pathway for mediating stimulus–response associations for sensorimotor habits

Thalamic POm projections to the dorsolateral striatum of rats: potential pathway for mediating stimulus–response associations for sensorimotor habits

Phasic and Tonic Patterns of Locus Coeruleus Output Differentially Modulate Sensory Network Function in the Awake Rat

Locus Ceruleus Regulates Sensory Encoding by Neurons and Networks in Waking Animals

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