Thalamic neuromodulation in epilepsy: A primer for emerging circuit-based therapies

Zheng, Bryan; Liu, David D.; Theyel, Brian; Abdulrazeq, Hael; Kimata, Anna R.; Lauro, Peter M; Asaad, Wael F.

doi:10.1080/14737175.2023.2176752

Cited by 2 publications

(3 citation statements)

References 236 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The thalamus in particular has been studied as a target for neuromodulation given its importance as a relay node for epileptic networks. 3 – 8 The SANTE trial was a landmark point showing promising results for deep brain stimulation (DBS) targeting the anterior nucleus of the thalamus, particularly in patients with seizures originating from the temporal lobes. 4 Given its projections to motor and premotor frontal regions, the centromedian thalamus has also been considered a viable option and studied in patients with multifocal epilepsy with predominantly frontal origin.…”

Section: Transcriptmentioning

confidence: 99%

See 1 more Smart Citation

Robot-assisted, CT-guided placement of responsive neurostimulator system with bilateral centromedian thalamus depth electrodes for multifocal intractable epilepsy

Abdulrazeq,

Feler,

Kimata

et al. 2024

Neurosurgical Focus: Video

View full text Add to dashboard Cite

The responsive neurostimulator system has become increasingly popular in the surgical management of refractory epilepsy, with targeting of various thalamic nuclei showing promising results in select patients. A 42-year-old female presented for evaluation of refractory epilepsy consisting of generalized tonic-clonic and focal seizures with preserved awareness. Phase I and II monitoring suggested multifocal bilateral epilepsy with bilateral frontal onset, and the patient underwent robot-guided bilateral centromedian thalamic placement of the RNS System. In this operative video, the authors share their institutional experience and protocol utilizing the ExcelsiusGPS robot in the placement of the RNS System in the thalamus. The video can be found here: https://stream.cadmore.media/r10.3171/2024.4.FOCVID243

show abstract

Section: Transcriptmentioning

confidence: 99%

“… 4 Given its projections to motor and premotor frontal regions, the centromedian thalamus has also been considered a viable option and studied in patients with multifocal epilepsy with predominantly frontal origin. 3 , 9 …”

Section: Transcriptmentioning

confidence: 99%

Robot-assisted, CT-guided placement of responsive neurostimulator system with bilateral centromedian thalamus depth electrodes for multifocal intractable epilepsy

Abdulrazeq,

Feler,

Kimata

et al. 2024

Neurosurgical Focus: Video

View full text Add to dashboard Cite

show abstract

“…The growing understanding of the brain's anatomical and functional connectivity has been valuable, to a great degree, in epilepsy and functional neurosurgery. The convergentdivergent nature of cortico-thalamo-cortical circuitry has engendered great interest in targeting the thalamus as a potential control point for neuromodulation, especially for patients who are otherwise considered high risk for surgical resection of an epileptogenic focus [1][2][3][4][5]. The anterior and centromedian nuclei of the thalamus, and, to a lesser degree, the pulvinar nucleus, have each been used as targets in this context [1,6,7].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Role of the Pulvinar Nucleus of the Thalamus in Occipital Lobe Epilepsy: A Case Report

Abdulrazeq,

Kimata,

Blum

et al. 2024

Cureus

Self Cite

View full text Add to dashboard Cite

Understanding the role of the pulvinar nucleus may be critical for guiding circuit-targeted neurosurgical intervention in some patients. In this report, a 33-year-old female presented with focal onset occipital epilepsy with secondary generalization and with a previously radiated arteriovenous malformation within the right primary visual cortex. Phase II monitoring demonstrated the pulvinar nucleus was not involved in subclinical seizures restricted to the primary visual cortex, but it did become involved in clinical events with more extensive seizure spread into higher visual cortical regions. She underwent responsive neurostimulation (RNS) with implantation of leads within the primary visual cortex. This case demonstrates the late propagation of epileptic activity from the visual cortex to the pulvinar nucleus and illustrates the pulvinar nucleus' connections with higher-order visual areas.

show abstract

Thalamic neuromodulation in epilepsy: A primer for emerging circuit-based therapies

Cited by 2 publications

References 236 publications

Robot-assisted, CT-guided placement of responsive neurostimulator system with bilateral centromedian thalamus depth electrodes for multifocal intractable epilepsy

Robot-assisted, CT-guided placement of responsive neurostimulator system with bilateral centromedian thalamus depth electrodes for multifocal intractable epilepsy

Exploring the Role of the Pulvinar Nucleus of the Thalamus in Occipital Lobe Epilepsy: A Case Report

Contact Info

Product

Resources

About