Thalamic metabolic rate predicts EEG alpha power in healthy control subjects but not in depressed patients

Lindgren, Kristen A.; Larson, Christine L.; Schaefer, Stacey M.; Abercrombie, Heather C.; Ward, Robert T.; Oakes, Terrence R.; Holden, James E.; Perlman, Scott; Benca, Ruth M.; Davidson, Richard J.

doi:10.1016/s0006-3223(98)00350-3

Cited by 106 publications

(70 citation statements)

References 27 publications

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“…Neurovascular coupling has been a topic of major interest due to its relationship with pathological brain physiology. There is evidence that neurovascular coupling is affected by aging, anesthesia, and diseases including depression, stroke, hypertension, Alzheimer's, epilepsy, subarachnoid hemorrhage, and traumatic brain injury (Attwell and Iadecola, 2002;Bari et al, 2012;D'Esposito et al, 2003;Girouard and Iadecola, 2006;Len and Neary, 2011;Lindgren et al, 1999;Malonek, 1997;Masamoto and Kanno, 2012). This study was intended to investigate the utility of human wholehead EEG+fNIRS in tracking neurovascular coupling in cortex.…”

Section: Introductionmentioning

confidence: 99%

Hemodynamic correlates of spontaneous neural activity measured by human whole-head resting state EEG + fNIRS

2016

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The brains of awake, resting human subjects display spontaneously occurring neural activity patterns whose magnitude is typically many times greater than those triggered by cognitive or perceptual performance. Such resting state (RS) activity is thought to reflect the functional organization of the brain. In addition, both evoked and RS activation affect local cerebral hemodynamic properties through processes collectively referred to as neurovascular coupling. This is a major topic of interest due to its relationship with pathological conditions that include hypertension, stroke, subarachnoid hemorrhage, and traumatic brain injury. Its investigation calls for an ability to track both the neural and vascular aspects of brain function. We used scalp electroencephalography (EEG), which provided a measure of the electrical potentials generated by cortical postsynaptic currents. Simultaneously we utilized functional near-infrared spectroscopy (NIRS) to continuously monitor hemoglobin concentration changes in superficial cortical layers. The multi-modal signal from 18 healthy adult subjects allowed us to investigate the association of neural activity in a range of frequencies over the whole-head to local changes in hemoglobin concentrations. Our results verified the delayed alpha (8-16 Hz) modulation of hemodynamics in posterior areas known from the 3 literature. They also indicated strong beta (16-32 Hz) modulation of hemodynamics. Analysis revealed, however, that beta modulation was likely generated by the alpha-beta coupling in EEG. Signals from the inferior electrode sites were dominated by scalp muscle related activity.Our study aimed to characterize the phenomena related to neurovascular coupling observable by practical, cost-effective, and non-invasive multi-modal techniques.

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Section: Introductionmentioning

confidence: 99%

Hemodynamic correlates of spontaneous neural activity measured by human whole-head resting state EEG + fNIRS

2016

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“…Another common finding is low voltage alpha (LVA) in the EEGs of alcohol dependent individuals. As mentioned previously, increased alpha activity is indicative of a relaxed, alert state; whereas, alpha activity decreases and beta activity increases during a state of arousal [17,18,19,20]. Thus, the resting EEG of alcoholics with LVA more closely resembles an aroused state as seen in control participants without a history of alcohol dependence [17].…”

Section: Introductionmentioning

confidence: 80%

“…Manual eye-blink rejection was used to eliminate participants with EEG values of + or − 50μV at the ocular movement electrode. Resulting absolute power (uV 2 ) values corresponded to the frequency bands alpha1 (8.5-10.5 Hz), alpha2 (10.6-13.5 Hz), beta1 (13.5-19.5 Hz) and beta2 (19.5-26 Hz) [19].…”

Section: Spectral Analysesmentioning

confidence: 99%

“…In this technique, brain electrical activity is recorded in the relaxed state with eyes open or eyes closed, resulting in absolute power (uV 2 ) values corresponded to the EEG frequency bands of alpha, beta, delta and theta. Alpha activity is indicative of a relaxed, alert state; whereas, beta activity is indicative of cortical arousal [17,18,19,20]. As opposed to recordings produced during sleep, clinically significant increases delta and theta activity during the awake but resting state may be characteristic of generalized brain dysfunction [21].…”

Section: Introductionmentioning

confidence: 99%

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Transdermal Nicotine Administration and the Electroencephalographic Activity of Substance Abusers in Treatment

Ceballos

Tivis²,

Prather³

et al. 2008

Journal of Addiction Medicine

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Objectives-It is widely recognized that individuals with alcohol or illicit substance abuse disorders often smoke cigarettes. However, few studies have examined the direct effects of nicotine among substance abuse subgroups. The current study examined patterns of electroencephalographic (EEG) activity in alcohol-dependent (AD), stimulant-dependent (StimD), alcohol-and stimulantdependent (ASD) participants, as well as community controls (CC). All participants were regular smokers.Methods-After overnight nicotine abstinence, subjects were administered either a high (14 or 21 mg) or low (7mg) dose transdermal nicotine patch. EEG data were collected during a 2 minute eyes open and 5 minute eyes closed baseline recording session, which occurred as part of a larger study of brain electrophysiology.Results-The most interesting finding was a differential pattern of nicotine dose effects by group. EEGs of Controls and ASD participants did not distinguish between high and low nicotine doses; whereas, nicotine administration in the AD and StimD groups resulted in opposite findings across a range of spectral bands.Conclusions-Although further research is warranted, these results may have implications for the study of smoking cessation and attentional functioning among substance abusers in treatment. These data suggest that nicotine-related changes in neurophysiology may be associated with specific brain areas and/or specific drug histories and reinforce the need for caution in generalizing among such groups.

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“…Studies utilizing neuroimaging techniques revealed central neural correlates including the thalamus, which particularly attracted much interest because the results indicated that surface EEG reflected deep brain network (DBN) activities. Although whether the correlation is positive [50][51][52] or negative [53,54] has been a matter of argument in published papers, a recent report [55,56] concluded this issue through its findings that neural correlates with occipital EEG alpha rhythms depend on the frequencies of alpha rhythm power fluctuations. This report also gives the best suggestion that a region of the thalamus, associated with the brain stem and anterior cingulate cortex, is positively correlated with the slow fluctuation components of the alpha rhythm power.…”

Section: Introductionmentioning

confidence: 99%

Pain-Relief Effects of Aroma Touch Therapy with <i>Citrus junos</i> Oil Evaluated by Quantitative EEG Occipital Alpha-2 Rhythm Powers

Bohgaki¹,

Katagiri²,

Usami³

2014

JBBS

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Aroma touch therapy is widely used in clinical fields for alleviating pain-related symptoms; however, few studies have reported the pain-relief mechanisms. The present study aimed to elucidate the analgesic effects of aroma touch therapy with Citrus junos oil based on the quantitative evaluation of deep brain network (DBN) activity using electroencephalogram (EEG) occipital alpha-2 rhythm (10 -13 Hz) powers. Experimental investigations were performed with 13 healthy volunteers using the cold pressor task for simulating chronic pain in three different sessions: a baseline session with no therapies, a control session with a touch therapy, and an aroma touch therapy. We have found for the first time that the interviewed pain ratings represented by Numeric Rating Scale (NRS) scores were strongly correlated with a DBN activity index, which was derived from the slow fluctuation components of occipital EEG alpha-2 rhythm powers. The correlation was characterized by a V-shaped curve in the DBN activity index versus the pain rating, i.e., the NRS score, which provided the complete analgesic states (NRS = 0) for some subjects under aroma touch therapy at an appropriate DBN activity index. Such analgesic states were not so strongly correlated with emotional valence. In conclusion, aroma touch therapy may directly modulate DBN activity so that pain-induced outcomes are minimized.

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Thalamic metabolic rate predicts EEG alpha power in healthy control subjects but not in depressed patients

Cited by 106 publications

References 27 publications

Hemodynamic correlates of spontaneous neural activity measured by human whole-head resting state EEG + fNIRS

Hemodynamic correlates of spontaneous neural activity measured by human whole-head resting state EEG + fNIRS

Transdermal Nicotine Administration and the Electroencephalographic Activity of Substance Abusers in Treatment

Pain-Relief Effects of Aroma Touch Therapy with <i>Citrus junos</i> Oil Evaluated by Quantitative EEG Occipital Alpha-2 Rhythm Powers

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Thalamic metabolic rate predicts EEG alpha power in healthy control subjects but not in depressed patients

Cited by 106 publications

References 27 publications

Hemodynamic correlates of spontaneous neural activity measured by human whole-head resting state EEG + fNIRS

Hemodynamic correlates of spontaneous neural activity measured by human whole-head resting state EEG + fNIRS

Transdermal Nicotine Administration and the Electroencephalographic Activity of Substance Abusers in Treatment

Pain-Relief Effects of Aroma Touch Therapy with &lt;i&gt;Citrus junos&lt;/i&gt; Oil Evaluated by Quantitative EEG Occipital Alpha-2 Rhythm Powers

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Product

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About

Pain-Relief Effects of Aroma Touch Therapy with <i>Citrus junos</i> Oil Evaluated by Quantitative EEG Occipital Alpha-2 Rhythm Powers