Thalamic input to areas 3a and 2 in monkeys.

Friedman, David P.; Jones, Elizabeth

doi:10.1152/jn.1981.45.1.59

Cited by 177 publications

(77 citation statements)

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“…These laminar terminations are the same as those described previously by autoradiography . The more dorsally and anteriorly placed injections in VP led to additional labeling of thalamocortical fiber terminations in areas 3a and 2, as anticipated from earlier studies (Friedman and Jones, 1981), and injections that leaked along the micropipette track into the anterior pulvinar nucleus gave additional labeling in area 5, in accord with previous investigations Pons and Kaas, 1985). The present analysis will focus on the projections to area 3b.…”

Section: Resultssupporting

confidence: 82%

“…Areas 3b and 1 receive their principal thalamic inputs from the large cutaneous core of VP . Areas 3a and 2 receive theirs from the anterodorsal proprioceptive shell (Friedman and Jones, 1981), which was not affected in most of the injections of VP. This study, therefore, does not address the issue of divergence in the projection to areas 3a and 2, nor does it deal with projections to other cortical areas that were labeled in instances in which an injection pipette leaked dye into the anterior pulvinar nucleus en route to VP.…”

Section: Projections To Areamentioning

confidence: 93%

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Extensive Divergence and Convergence in the Thalamocortical Projection to Monkey Somatosensory Cortex

et al. 1998

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This study examined the extent of thalamocortical divergence as a potential determinant of activity-dependent representational plasticity in area 3b of adult monkey somatosensory cortex. Single or paired injections of anterogradely transported tracers, of varying anteroposterior extent, were made horizontally from behind in defined parts of the body representation in the ventral posterior lateral (VPL) and/or ventral posterior medial (VPM) thalamic nuclei, and the distribution and density of labeled thalamocortical terminations were mapped in cortex. Injections of increasing size in any dimension of VPL or VPM resulted in increasing accumulation of labeled terminals within the region of projection, implying extensive convergence of individual axons. Anteroposteriorly elongated injections labeled mediolaterally extended but anteroposteriorly restricted zones in cortex. Dorsoventral placement of an injection in VPL or VPM determined anteroposterior location of labeling in cortex.Dual injections separated mediolaterally or dorsoventrally by ϳ1 mm, and in different parts of the thalamic body or head-face representation gave rise to labeled thalamocortical terminations that overlapped extensively. For injection sites at different anteroposterior levels in VPL or VPM, the area of cortical convergence was related to their extent of anteroposterior coincidence. Labeled terminations arising from injections in immediately adjacent parts of VPL and VPM did not overlap in cortex.The extent of thalamocortical divergence and convergence revealed by these experiments is greater than that predictable from labeling of single axons and is sufficiently great to account for representational plasticity that exceeds the 1.5 mm cortical "distance limit."

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Section: Resultssupporting

confidence: 82%

Section: Projections To Areamentioning

confidence: 93%

Extensive Divergence and Convergence in the Thalamocortical Projection to Monkey Somatosensory Cortex

et al. 1998

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“…Friedman and Jones [17] had also indicated from single-unit re cording that VPL should be divided into an anterodorsal shell -called VPLs by Dykes et al [16] and Kaas et al [35] -in which neurons re sponded only to stimulation of deep (i.e., muscle and joint) receptors and a central core (called VPL by Dykes et al and Kaas et al) in which neurons responded only to stimulation of cutaneous receptors. Fur thermore, neurons in the anterodorsal shell projected only to areas 3a or 2, while those in the central core projected only to areas 3b and 1.…”

Section: Physiological Subdivisions Of Vplmentioning

confidence: 99%

“…This was examined by Friedman and Jones [17] who showed that the border between cytoarchitectonic areas 4 and 3a in the cortex also represented a border between the two systems of thalamocortical projections. Fiber ramifications derived from VPL cells ended in areas 3a, 3b, 1, and 2 but not in area 4, while those derived from VLp cells and ending in area 4 did not cross the border into area 3a.…”

mentioning

confidence: 99%

Correlation and Revised Nomenclature of Ventral Nuclei in the Thalamus of Human and Monkey

Jones

1990

Stereotact Funct Neurosurg

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The application of histochemical and immunocytochemical methods to the human thalamus, when allied with traditional staining methods, permits a clearer definition of the borders between many nuclei. The findings of electrophysiological and anatomical tracing studies in monkeys can then be correlated with the human material and a nomenclature that is applicable to both monkeys and humans introduced. The ventral nuclei can be divided into four channels relaying pallidal, substantia nigral, cerebellar, and lemniscal information separately to the cerebral cortex. The lemniscal relay is further divided into a proprioceptive component and a cutaneous component, corresponding to Hassler''s V.c.e.a and V.c.e.p nuclei, respectively, and now called VPLa and VPLp.

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“…These structures form pathways that have been demonstrated by anatomical studies in nonhuman primates (Friedman and Jones 1981;Manger et al 1995;Walker 1938Walker , 1982 and by diffusion tensor imaging studies in humans, although the latter have relatively low spatial resolution (Behrens et al 2003). …”

Section: Normal Somatic Sensory Thalamus: Summarymentioning

confidence: 96%

Neuronal responses to tactile stimuli and tactile sensations evoked by microstimulation in the human thalamic principal somatic sensory nucleus (ventral caudal)

Schmid

Chien

Greenspan

et al. 2016

Journal of Neurophysiology

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. Neuronal responses to tactile stimuli and tactile sensations evoked by microstimulation in the human thalamic principal somatic sensory nucleus (ventral caudal). J Neurophysiol 115: 2421-2433, 2016. First published February 10, 2016 doi:10.1152/jn.00611.2015.-The normal organization and plasticity of the cutaneous core of the thalamic principal somatosensory nucleus (ventral caudal, Vc) have been studied by single-neuron recordings and microstimulation in patients undergoing awake stereotactic operations for essential tremor (ET) without apparent somatic sensory abnormality and in patients with dystonia or chronic pain secondary to major nervous system injury. In patients with ET, most Vc neurons responded to one of the four stimuli, each of which optimally activates one mechanoreceptor type. Sensations evoked by microstimulation were similar to those evoked by the optimal stimulus only among rapidly adapting neurons. In patients with ET, Vc was highly segmented somatotopically, and vibration, movement, pressure, and sharp sensations were usually evoked by microstimulation at separate sites in Vc. In patients with conditions including spinal cord transection, amputation, or dystonia, RFs were mismatched with projected fields more commonly than in patients with ET. The representation of the border of the anesthetic area (e.g., stump) or of the dystonic limb was much larger than that of the same part of the body in patients with ET. This review describes the organization and reorganization of human Vc neuronal activity in nervous system injury and dystonia and then proposes basic mechanisms. amputation; dystonia; neurophysiology; spinal transection; single neuron recordings; ventral posterior thalamus

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Thalamic input to areas 3a and 2 in monkeys.

Cited by 177 publications

References 0 publications

Extensive Divergence and Convergence in the Thalamocortical Projection to Monkey Somatosensory Cortex

Extensive Divergence and Convergence in the Thalamocortical Projection to Monkey Somatosensory Cortex

Correlation and Revised Nomenclature of Ventral Nuclei in the Thalamus of Human and Monkey

Neuronal responses to tactile stimuli and tactile sensations evoked by microstimulation in the human thalamic principal somatic sensory nucleus (ventral caudal)

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