Thalamic Connectivity System Across Psychiatric Disorders: Current Status and Clinical Implications

Hwang, Wu Jeong; Kwak, Yoo Bin; Cho, Kang Ik K.; Lee, Tae Young; Oh, Harin; Ha, Minji; Kim, Minah; Kwon, Jun Soo

doi:10.1016/j.bpsgos.2021.09.008

Cited by 31 publications

(20 citation statements)

References 105 publications

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“…Limiting the understanding of thalamic subnuclei involvement in affective networks, many papers evaluate the entire thalamus as one region of interest due to the error-prone nature of labeling and segmenting highly individual and anatomically varied thalamic subnuclei [46]. More recent papers have reported mediodorsal and pulvinar nuclei as contributing to affective cortical networks, while another study described changes in functional connectivity between motor thalamus subregions, such as VIM, and limbic cortex as contributing to depression [46][47][48][49]. While VIM is classically thought of as a motor nucleus of the thalamus, its functional connections with cerebello-thalamo-cortical networks demonstrated to be involved in depression may indicate an affective function of this region.…”

Section: Discussionmentioning

confidence: 99%

Depression Scores following Ventral Intermediate Nucleus Deep Brain Stimulation for Essential Tremor: A Meta-Analysis

Gupta¹,

Paulo²,

Sun³

et al. 2023

Stereotact Funct Neurosurg

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Background: Essential tremor (ET) patients present with both motor and non-motor symptoms including depression. Although deep brain stimulation (DBS) of the ventral intermediate nucleus (VIM) is used to treat motor symptoms of ET, there is no consensus as to how VIM DBS influences non-motor symptoms, specifically depression. Objective: The objective of this study was to conduct a meta-analysis of available studies investigating change in pre- to postoperative depression scores as measured by Beck Depression Inventory (BDI) in ET patients receiving VIM DBS. Methods: Inclusion criteria were randomized control trials or observational studies of patients undergoing unilateral/bilateral VIM DBS. Non-ET patients, case reports, patients <18 years old, only non-VIM electrode placement, non-English articles, and abstracts were excluded. The primary outcome was change in BDI score from the preoperative time point to the last available follow-up. Pooled estimates of overall effect for BDI standardized mean difference were calculated using random effects models with the inverse variance method. Results: Seven studies divided into eight cohorts for a total of 281 ET patients met inclusion criteria. Pooled preoperative BDI score was 12.44 (95% CI [6.63–18.25]). A statistically significant decrease in depression scores was observed postoperatively (SMD = −0.29, 95% CI [−0.46 to −0.13], p = 0.0006). Pooled postoperative BDI score was 9.18 (95% CI [4.98–13.38]). A supplementary analysis which included an additional study with an estimated standard deviation at last follow-up was conducted. There was also a statistically significant decrease in depression postoperatively (9 cohorts, n = 352, SMD = −0.31, 95% CI [−0.46 to −0.16], p < 0.0001). Conclusions: Both quantitative and qualitative analyses of the existing literature suggest that VIM DBS improves depression postoperatively among ET patients. These results may guide surgical risk-benefit analysis and counseling for ET patients undergoing VIM DBS.

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Section: Discussionmentioning

confidence: 99%

Depression Scores following Ventral Intermediate Nucleus Deep Brain Stimulation for Essential Tremor: A Meta-Analysis

Gupta¹,

Paulo²,

Sun³

et al. 2023

Stereotact Funct Neurosurg

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“…It’s critical for the transmission and processing of external information and thereby modulates essential tasks such as wakefulness, sleep and memory. It was shown in both animal models and humans that there are thalamic connectivity deficits in psychiatric disorders, including schizophrenia [ 17 ]. There is also evidence of altered thalamic microstructure, e.g., in the mediodorsal nucleus, thalamo-prefrontal and thalamo-somatosensory/parietal connectivity [ 17 ].…”

Section: Objectivementioning

confidence: 99%

Sex-specific cortical, hippocampal and thalamic whole genome transcriptome data from controls and a G72 schizophrenia mouse model

Papazoglou,

Henseler,

Weickhardt

et al. 2024

BMC Res Notes

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Objectives The G72 mouse model of schizophrenia represents a well-known model that was generated to meet the main translational criteria of isomorphism, homology and predictability of schizophrenia to a maximum extent. In order to get a more detailed view of the complex etiopathogenesis of schizophrenia, whole genome transcriptome studies turn out to be indispensable. Here we carried out microarray data collection based on RNA extracted from the retrosplenial cortex, hippocampus and thalamus of G72 transgenic and wild-type control mice. Experimental animals were age-matched and importantly, both sexes were considered separately. Data description The isolated RNA from all three brain regions was purified, quantified und quality controlled before initiation of the hybridization procedure with SurePrint G3 Mouse Gene Expression v2 8 × 60 K microarrays. Following immunofluorescent measurement und preprocessing of image data, raw transcriptome data from G72 mice and control animals were extracted and uploaded in a public database. Our data allow insight into significant alterations in gene transcript levels in G72 mice and enable the reader/user to perform further complex analyses to identify potential age-, sex- and brain-region-specific alterations in transcription profiles and related pathways. The latter could facilitate biomarker identification and drug research and development in schizophrenia research.

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“…The first-order nuclei relay driver inputs from subcortical structures and relay the primary sensory information to the cortex, while the higher-order nuclei receive driver inputs from layer five of upstream cortical regions and relay the information to other cortical sites, forming the cortico-thalamo-cortical loops ( 6 ). In this manner, the thalamus is an important relay station of signal transmission in the brain, whose dysconnectivity may contribute to symptoms and disturbances in psychiatric patients, including depressed individuals ( 7 ). Specifically, altered thalamic FC has been reported in MDD with the somatosensory areas ( 8 , 9 ), superior frontal gyrus ( 10 ), dorsal anterior cingulate ( 11 ), and middle frontal gyrus ( 12 ).…”

Section: Introductionmentioning

confidence: 99%

Abnormal dynamic functional connectivity of thalamic subregions in patients with first-episode, drug-naïve major depressive disorder

Zheng

Liu

et al. 2023

Front. Psychiatry

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BackgroundRecent studies have shown that major depressive disorder (MDD) is associated with altered intrinsic functional connectivity (FC) of the thalamus; however, investigations of these alterations at a finer time scale and the level of thalamic subregions are still lacking.MethodsWe collected resting-state functional MRI data from 100 treatment-naïve, first-episode MDD patients and 99 age-, gender- and education-matched healthy controls (HCs). Seed-based whole-brain sliding window-based dFC analyses were performed for 16 thalamic subregions. Between-group differences in the mean and variance of dFC were determined using threshold-free cluster enhancement algorithm. For significant alterations, there relationships with clinical and neuropsychological variables were further examined via bivariate and multivariate correlation analyses.ResultsOf all thalamic subregions, only the left sensory thalamus (Stha) showed altered variance of dFC in the patients characterized by increases with the left inferior parietal lobule, left superior frontal gyrus, left inferior temporal gyrus, and left precuneus, and decreases with multiple frontal, temporal, parietal, and subcortical regions. These alterations accounted for, to a great extent, clinical, and neuropsychological characteristics of the patients as revealed by the multivariate correlation analysis. In addition, the bivariate correlation analysis revealed a positive correlation between the variance of dFC between the left Stha and right inferior temporal gurus/fusiform and childhood trauma questionnaires scores (r = 0.562, P < 0.001).ConclusionThese findings suggest that the left Stha is the most vulnerable thalamic subregion to MDD, whose dFC alterations may serve as potential biomarkers for the diagnosis of the disease.

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Thalamic Connectivity System Across Psychiatric Disorders: Current Status and Clinical Implications

Cited by 31 publications

References 105 publications

Depression Scores following Ventral Intermediate Nucleus Deep Brain Stimulation for Essential Tremor: A Meta-Analysis

Depression Scores following Ventral Intermediate Nucleus Deep Brain Stimulation for Essential Tremor: A Meta-Analysis

Sex-specific cortical, hippocampal and thalamic whole genome transcriptome data from controls and a G72 schizophrenia mouse model

Abnormal dynamic functional connectivity of thalamic subregions in patients with first-episode, drug-naïve major depressive disorder

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