Thalamic and cerebellar hypoperfusion in single photon emission computed tomography may differentiate multiple system atrophy and progressive supranuclear palsy

Alster, Piotr; Nieciecki, Michał; Koziorowski, Dariusz; Cacko, Andrzej; Charzyńska, Ingeborga; Królicki, Leszek; Friedman, Andrzej

doi:10.1097/md.0000000000016603

Cited by 10 publications

(11 citation statements)

References 15 publications

(27 reference statements)

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“…Interestingly, samples from three cases clinically diagnosed with multiple system atrophy were more consistently positive than the other non 4R controls, and as such, were not distinguishable statistically from the PSP or CBS/CBD cases. This might be due to the difficulty in accurately discriminating PSP, CBD and multiple system atrophy on a purely clinical basis [1,21]. When we compared maximum ThT amplitudes, the mean values for the PSP and CBS/CBD cases were higher than those for the non 4R controls, but several outliers in the latter group eliminated statistical significance for the difference in means (Fig.…”

Section: R Rt-quic Analysis Of Intra-vitam Csfmentioning

confidence: 97%

4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration

Saijo¹,

Metrick²,

Koga

et al. 2019

Acta Neuropathol

104

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To address the need for more meaningful biomarkers of tauopathies, we have developed an ultrasensitive tau seed amplification assay (4R RT-QuIC) for the 4-repeat (4R) tau aggregates of progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and other diseases with 4R tauopathy. The assay detected seeds in 10 6 -10 9 -fold dilutions of 4R tauopathy brain tissue but was orders of magnitude less responsive to brain with other types of tauopathy, such as from Alzheimer's disease cases. The analytical sensitivity for synthetic 4R tau fibrils was ~ 50 fM or 2 Byron Caughey,

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Section: R Rt-quic Analysis Of Intra-vitam Csfmentioning

confidence: 97%

4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration

Saijo¹,

Metrick²,

Koga

et al. 2019

Acta Neuropathol

104

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“…Asymmetrical atrophy tended to occur with midbrain and cerebellar peduncle decreases of volume. Additionally, no significant differences in perfusion were detected [9,10,20].…”

Section: Clinical Implications/future Directionsmentioning

confidence: 82%

“…We are aware of the limitations of our study such as the relatively small number of patients. However, various studies evaluating other features, possibly facilitating the examination of CBS, have been based on smaller numbers of patients [9,10,20]. The disparity between the number of male and female patients in the CBS group is related to the rarity of this syndrome.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil-to-lymphocyte ratio (NLR) at boundaries of Progressive Supranuclear Palsy Syndrome (PSPS) and Corticobasal Syndrome (CBS)

Alster

Madetko

Friedman

2021

Neurol Neurochir Pol.

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Aim of the study. To examine possible features of neuroinflammation in progressive supranuclear palsy -Richardson syndrome and corticobasal syndrome (CBS).Clinical rationale for the study. Neutrophil-to-lymphocyte ratio (NLR) is a parameter reflecting inflammation used in numerous branches of medicine. The search for pathogenesis of the diseases partly related to inflammatory processes confirms the need to obtain possible factors which could be relatively easily verified. NLR is a benchmark routinely evaluated in most hospitalised patients.Materials and methods. 23 patients with a clinical diagnosis of PSP-RS, 18 patients with CBS, and 32 healthy controls, were included in the study. Blood samples were assessed in the context of neutrophil and lymphocyte rates. Subsequently, the results were transformed into neutrophil-to-lymphocyte ratio (NLR). The NLRs from each group were statistically assessed using a Kruskal-Wallis test and post-hoc analysis.Results. Statistical analysis confirmed significant differences in NLR between PSP-RS and control group. No other significant differences were observed.Clinical implications. The possible use of NLR in the additional examination of atypical parkinsonisms. Conclusions.To the best of our knowledge, this is the first study comparing this aspect of neuroinflammation in PSP and CBS. It presents NLR as a promising non-specific parameter in neurodegenerative diseases.

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“…Single-photon emission computed tomography (SPECT), with its various radiotracers such as 99m Tc-HMPAO, is more accessible which, however, is affected by low specificity. Previous studies with SPECT- 99m Tc-HMPAO conducted on patients with tauopathic atypical parkinsonism showed thalamic hypoperfusion in PSP which, however, did not confirm any significant differences of perfusion between PSP and CBS ( 6 , 7 ). A combined assessment using dopamine transporter and perfusion SPECT was evaluated in a paper by Van Laere et al where the authors attempted to define the role of this assessment in the differential diagnosis of parkinsonism ( 8 ).…”

Section: Introductionmentioning

confidence: 60%

The Role of Frontal Assessment Battery and Frontal Lobe Single-Photon Emission Computed Tomography in the Differential Diagnosis of Progressive Supranuclear Palsy Variants and Corticobasal Syndrome—A Pilot Study

et al. 2021

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Progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) are clinical syndromes classified as atypical parkinsonism. Due to their overlapping symptomatology, recent research shows the necessity of finding new methods of examination of these clinical entities. PSP is a heterogenic disease. PSP Richardson-Steele Syndrome (PSP-RS) and parkinsonism predominant (PSP-P) are the most common clinical variants of progressive supranuclear palsy syndrome. The different clinical course and life expectancy of PSP-RS and PSP-P stress the need of efficient examination in the early stages. The aim of the study was to evaluate the possible feasibility of the combined use of frontal assessment battery (FAB) and single-photon emission computed tomography (SPECT) in the differentiation of PSP-RS, PSP-P, and CBS. The findings show that FAB may be interpreted as a possible supplementary tool in the differential diagnosis of PSP-P and PSP-RS. The differences in SPECT are less pronounced. The study does not show any advantages of performing combined frontal SPECT and FAB in the differential examination of PSP and CBS. Moreover, PSP-RS and CBS, in a detailed evaluation of the frontal lobe, do not show any significant differences. This is a relatively small study which, however, highlights the relevant features of clinical examination of these rare entities.

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Thalamic and cerebellar hypoperfusion in single photon emission computed tomography may differentiate multiple system atrophy and progressive supranuclear palsy

Cited by 10 publications

References 15 publications

4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration

4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration

Neutrophil-to-lymphocyte ratio (NLR) at boundaries of Progressive Supranuclear Palsy Syndrome (PSPS) and Corticobasal Syndrome (CBS)

The Role of Frontal Assessment Battery and Frontal Lobe Single-Photon Emission Computed Tomography in the Differential Diagnosis of Progressive Supranuclear Palsy Variants and Corticobasal Syndrome—A Pilot Study

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