(−)-Thaipetaline, a tetrahydroprotoberberine from a Malayan annonaceae

Lavault, M.; Guinaudeau, Hélène; Bruneton, J.; Sévenet, Thierry; Hadi, Hamid A.

doi:10.1016/0031-9422(90)85344-f

Cited by 22 publications

(15 citation statements)

References 8 publications

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“…In addition, alkaloid compounds also reported have potent activity against gastric ulcers [42]. The previous studies by Nordin et al [23] and Lavault et al found several alkaloids in these plants [43]. This could explain that these classes of compounds contribute to the antiulcer activity of both E. pulchrum extracts.…”

Section: Discussionmentioning

confidence: 92%

Anti-Ulcerogenic Effect of Methanolic Extracts from Enicosanthellum pulchrum (King) Heusden against Ethanol-Induced Acute Gastric Lesion in Animal Models

et al. 2014

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A natural source of medicine, Enicosanthellum pulchrum is a tropical plant which belongs to the family Annonaceae. In this study, methanol extract from the leaves and stems of this species was evaluated for its gastroprotective potential against mucosal lesions induced by ethanol in rats. Seven groups of rats were assigned, groups 1 and 2 were given Tween 20 (10% v/v) orally. Group 3 was administered omeprazole 20 mg/kg (10% Tween 20) whilst the remaining groups received the leaf and stem extracts at doses of 150 and 300 mg/kg, respectively. After an additional hour, the rats in groups 2–7 received ethanol (95% v/v; 8 mL/kg) orally while group 1 received Tween 20 (10% v/v) instead. Rats were sacrificed after 1 h and their stomachs subjected to further studies. Macroscopically and histologically, group 2 rats showed extremely severe disruption of the gastric mucosa compared to rats pre-treated with the E. pulchrum extracts based on the ulcer index, where remarkable protection was noticed. Meanwhile, a significant percentage of inhibition was shown with the stem extract at 62% (150 mg/kg) and 65% (300 mg/kg), whilst the percentage with the leaf extract at doses of 150 and 300 mg/kg was 63% and 75%, respectively. An increase in mucus content, nitric oxide, glutathione, prostaglandin E2, superoxide dismutase, protein and catalase, and a decrease in malondialdehyde level compared to group 2 were also obtained. Furthermore, immunohistochemical staining of groups 4–7 exhibited down-regulation of Bax and up-regulation of Hsp70 proteins. The methanol extract from the leaves and the stems showed notable gastroprotective potential against ethanol.

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Section: Discussionmentioning

confidence: 92%

Anti-Ulcerogenic Effect of Methanolic Extracts from Enicosanthellum pulchrum (King) Heusden against Ethanol-Induced Acute Gastric Lesion in Animal Models

et al. 2014

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“…This tree is confined to mountain forests at an altitude of 1200-1500 m (Burkill, 1966;David, 1989). Several isoquinoline alkaloids have been isolated from this species such as (−)asimilobine, (−)anonaine, (−)norliridine, liriodenine and (−)scoulerine (Lavault et al, 1990). However, to our knowledge, no biological activity of this species has been reported so far.…”

Section: Introductionmentioning

confidence: 81%

Platelet-activating factor (PAF) receptor binding activity of the roots ofEnicosanthellum pulchrum

Nordin

Jalil

Jantan

et al. 2011

Pharmaceutical Biology

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“…[18][19][20] With regard to compound 4, this alkaloid was first found in Polyalthia stenopetala (Annonaceae), with its structure determined by 1H NMR analysis. 21 It belongs to the rare group of 2,3,4-trisubstituted tetrahydroprotoberberines; so far only three alkaloids of this type, including 4, have been identified. [21][22] The 13 C NMR data of 4 were obtained for first time in this study by interpretation of the HMQC and HMBC correlations.…”

Section: Discussionmentioning

confidence: 99%