Thai Patients With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis: Outcomes and Risk Factors for Mortality

Intapiboon, Porntip; Siripaitoon, Boonjing

doi:10.1097/rhu.0000000000001456

Cited by 2 publications

(2 citation statements)

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“…Previous studies have shown that BVAS could be used as a risk factor for poor prognosis of adult AAV patients and could predict relapse during the follow-up in patients with GPA and MPA (26)(27)(28)(29)(30)(31)(32). In this study, the univariate logistic regression model showed that initial PVAS > 15 was a risk factor for progression to ESRD in children with AAV (P < 0.05), which was in line with previous research results (26)(27)(28)(29)(30)(31)(32). In addition, the PVAS at onset was higher than the PVAS at 6 months [18.0 (12.8, 20.0) vs. 3.5 (0.5, 5.8)] (P < 0.05) (Table 5), suggesting that the PVAS might have the ability to reflect disease activity and therapeutic effect of AAV in children.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Analysis of 34 Cases of Primary Antineutrophil Cytoplasmic Antibody-Associated Vasculitis in Chinese Children

Pei

Rong

et al. 2021

Front. Pediatr.

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Background: This study aimed to summarize the clinicopathological features and prognostic risk factors of primary antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in children.Methods: Clinical and prognostic data for children admitted to our center with AAV between September 2003 and September 2020 were studied retrospectively. The incidence and risk factors of end-stage renal disease (ESRD) were calculated and analyzed.Results: Thirty-four children were enrolled; 28 were female, with a median onset age of 10 years. Except for one case negative for ANCA, the other 33 patients were diagnosed with microscopic polyangiitis (MPA). The most frequently involved organ was the kidney (100.0%), followed by the lungs (58.8%) and heart (50.0%). Twenty children (58.8%) progressed to ESRD with a median course of 3 months, and they were more likely to present respiratory and cardiovascular system involvement than were the non-ESRD group (P < 0.05). Patients in the ESRD group also had a higher serum creatinine level, 24-h protein excretion, Pediatric Vasculitis Activity Score (PVAS), and a lower level of estimated glomerular filtration rate (eGFR), hemoglobin, and complement C3 than had those in the non-ESRD group (P < 0.05). The main pathological manifestations were crescentic and sclerotic classes in the ESRD group and focal class in the non-ESRD group. After 6 months of induction therapy, 90.0% of cases achieved complete or partial remission. The multivariate logistic regression model showed that baseline eGFR < 60 ml/min/1.73 m2 was an independent risk factor for progressing to ESRD (OR = 0.016, 95% CI = 0.001~0.412, P = 0.012).Conclusions: AAV in children usually occurs in teenage girls, and the most commonly involved organ is the kidney, of which hematuria is the most common symptom, followed by proteinuria, abnormal renal function (eGFR < 90 ml/min/1.73 m2), etc. The primary type of AAV is MPA. Nearly 60% of patients progressed to ESRD with a median course of 3 months. Baseline eGFR < 60 ml/min/1.73 m2 is an independent risk factor for ESRD progression in AAV children.

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Section: Discussionmentioning

confidence: 99%

Clinicopathological Analysis of 34 Cases of Primary Antineutrophil Cytoplasmic Antibody-Associated Vasculitis in Chinese Children

Pei

Rong

et al. 2021

Front. Pediatr.

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“…NLR has been shown to be a potential predictor for poor prognosis in cancers and inflammatory diseases (14–17), and poor renal mortality in AAV (18–20). This is the first report on the association between a high NLR and HP in OMAAV.…”

Section: Discussionmentioning

confidence: 99%

Locations and Predictive Factors of Hypertrophic Pachymeningitis in Otitis Media With Antineutrophil Cytoplasmic Antigen-Associated Vasculitis

Morita¹,

Kitazawa²,

Yagi³

et al. 2022

Otol Neurotol

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Objective: To determine the locations and predictive factors of hypertrophic pachymeningitis (HP), a serious central complication of otitis media with antineutrophil cytoplasmic antigen-associated vasculitis (OMAAV). Study Design: Retrospective study. Setting: University hospital. Patients: Thirty-six patients with OMAAVunderwent contrast-enhanced magnetic resonance imaging (CE-MRI) of the brain, of whom 18 and 18 had or did not have HP, respectively. Main Outcome Measures: The location of HP lesions, which were detected as dural thickening on CE-MRI, was reviewed. Clinical characteristics, laboratory data, and audiometric data before treatment were correlated with the occurrence of HP. Results: HP lesions were most frequently observed in the middle cranial fossa, followed by the internal auditory meatus, tentorium cerebelli, and posterior cranial fossa, which were adjacent to the middle ear primary lesion. Headache was more frequently observed in patients with HP than without HP. The neutrophil-to-lymphocyte ratio (NLR) of the HP (+) group (median, 3.91; interquartile range, 2.50-6.06) was higher than that of the HP (−) group (median, 2.40; interquartile range, 2.01-3.03). The area under the receiver operating characteristic curve for the NLR was 0.741. An NLR of 3.46 had the highest sensitivity (61.1%) and specificity (94.4%) for predicting HP. Other markers of systemic inflammation and comorbidities of systemic diseases were not different between the groups. Conclusions: HP may not be a systemic manifestation of OMAAV but may be related to local lesions in the adjacent brain. A high NLR may be a predictive factor for comorbid HP. Therefore, CE-MRI should be considered for patients with a high NLR.

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Thai Patients With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis: Outcomes and Risk Factors for Mortality

Cited by 2 publications

References 42 publications

Clinicopathological Analysis of 34 Cases of Primary Antineutrophil Cytoplasmic Antibody-Associated Vasculitis in Chinese Children

Clinicopathological Analysis of 34 Cases of Primary Antineutrophil Cytoplasmic Antibody-Associated Vasculitis in Chinese Children

Locations and Predictive Factors of Hypertrophic Pachymeningitis in Otitis Media With Antineutrophil Cytoplasmic Antigen-Associated Vasculitis

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