Th2 Cytokines Augment IL-31/IL-31RA Interactions via STAT6-dependent IL-31RA Expression

Edukulla, Ramakrishna; Singh, Brijendra; Jegga, Anil G.; Sontake, Vishwaraj; Dillon, Stacey R.; Madala, Satish K.

doi:10.1074/jbc.m114.622126

Cited by 41 publications

(59 citation statements)

References 41 publications

(64 reference statements)

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“…37 In recent years, IL-31 has been associated to skin inflammatory disease through the activation of dermal dendritic cells and increase in inflammatory mediators, controlling cell proliferation and tissue remodeling. 38,39 The most consistent findings in this study were the strong positive correlations between IL-31 and the Th17 cytokine profile, so we suggest that IL-31 could induce a Th17 response directly or indirectly. IL-31 can signal through IL-31R, which is a heterodimer composed of IL-31RA and oncostatin M receptor β (OSMRβ).…”

Section: Discussionsupporting

confidence: 81%

A potential inflammatory role of IL-31 in psoriatic arthritis: A correlation with Th17 cytokine profile

Bautista-Herrera

Cruz-Mosso

Román-Fernández

et al. 2020

Int J Immunopathol Pharmacol

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The goals of our study were to determine the possible association of interleukin (IL)-31 with Th17 cytokine profile in serum and to quantify retinoic acid-related orphan receptor C ( RORC) mRNA expression in psoriatic arthritis (PsA) patients. This cross-sectional study was conducted in 50 patients with PsA and 30 control subjects (CS) matched by age and gender. The cytokine serum levels were quantified by magnetic bead–based assay using the Bio-Plex MAGPIX system, and RORC mRNA expression was determined by quantitative polymerase chain reaction (qPCR). As a result, significant differences in IL-31 were observed between study groups (77.23 pg/mL in PsA vs 64.4 pg/mL in CS, P < 0.001) and Th17 cytokine profile serum levels (IL-17A: 6.36 pg/mL in PsA vs 2.97 pg/mL in CS, P = 0.02; IL-17F: 44.15 pg/mL in PsA vs 23.36 pg/mL in PsA, P = 0.01; IL-17E: 3.03 pg/mL in PsA vs 0.82 pg/mL in CS, P < 0.001; IL-21: 36.45 pg/mL in PsA vs 12.44 pg/mL in CS, P = 0.02); however, significant differences were not observed for IL-23 (31.2 pg/mL in PsA vs 53.26 pg/mL in CS, P = 0.58). Furthermore, positive correlations between IL-31 and Th17 cytokine profile serum levels were found (IL-17A: rs = 0.64, P < 0.001; IL-17F: rs = 0.73, P < 0.001; IL-17E: rs = 0.70, P < 0.001; IL-21: rs = 0.54, P = 0.002; IL-23: rs = 0.5, P < 0.01). Regarding RORC gene expression, the PsA group showed an increase of 6.85-fold compared to the CS group. We did not find any association between the serum levels of cytokines and RORC gene expression. In conclusion, in PsA, there are increased serum levels of IL-31, IL-17A, IL-17F, IL-17E, and IL-21, but not IL-23. Moreover, there was a positive correlation of IL-31 with the Th17 cytokine profile and a high RORC gene expression. Altogether, these findings suggest a proinflammatory contribution of IL-31 in close association with the Th17 cytokine profile in PsA.

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Section: Discussionsupporting

confidence: 81%

A potential inflammatory role of IL-31 in psoriatic arthritis: A correlation with Th17 cytokine profile

Bautista-Herrera

Cruz-Mosso

Román-Fernández

et al. 2020

Int J Immunopathol Pharmacol

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“…Furthermore, similar to the regulation of IL-31, IL-31RA was shown to be induced in a STAT6-dependent manner in primary mouse macrophages by IL-4 and IL-13. Absence of the type II IL-4 receptor attenuated the expression of IL-31RA in vivo during allergic asthma [139]. In primary cultures and established lines of epithelial cells IL-31RA mRNA was induced by TGFb [135].…”

Section: Cytokine-receptor Interactionmentioning

confidence: 99%

Oncostatin M and interleukin-31: Cytokines, receptors, signal transduction and physiology

Hermanns

2015

Cytokine & Growth Factor Reviews

195

239

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“…In contrast to human, IL‐4 and IL‐13 do induce IL‐31RA expression in murine macrophages; therefore, species and cell‐type specific difference should be considered to compare the IL‐31/IL‐31R expression between human and mice. Deficiency of Il31ra does not affect the development of immune system .…”

Section: Structure and Expression Of The Il‐31/il‐31r Systemmentioning

confidence: 99%

Emerging role of interleukin‐31 and interleukin‐31 receptor in pruritus in atopic dermatitis

Furue

Yamamura

Kido‐Nakahara

et al. 2017

Allergy

191

162

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Atopic dermatitis (AD) is a chronic or chronically relapsing, eczematous, severely pruritic skin disorder associated with skin barrier dysfunction. The lesional skin of AD exhibits T helper 2 (T H 2)-deviated immune reactions. Interleukin-31 (IL-31), preferentially produced from T H 2 cells, is a potent pruritogenic cytokine, and its sys- First-line treatments of AD include the application of emollients for dry skin, topical steroids, and tacrolimus for skin inflammation, followed by second-line adjunct therapies such as systemic cyclosporine, short-term oral steroids, and ultraviolet radiation.

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Th2 Cytokines Augment IL-31/IL-31RA Interactions via STAT6-dependent IL-31RA Expression

Cited by 41 publications

References 41 publications

A potential inflammatory role of IL-31 in psoriatic arthritis: A correlation with Th17 cytokine profile

A potential inflammatory role of IL-31 in psoriatic arthritis: A correlation with Th17 cytokine profile

Oncostatin M and interleukin-31: Cytokines, receptors, signal transduction and physiology

Emerging role of interleukin‐31 and interleukin‐31 receptor in pruritus in atopic dermatitis

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