Th2 cytokine expression in atopic children with otitis media with effusion

Sobol, Steven E.; Taha, Rame; Schloss, Melvin D.; Mazer, Bruce; Manoukian, John J.; Tewfik, Ted L.; Hamid, Qutayba

doi:10.1016/s0091-6749(02)81282-9

Cited by 10 publications

(21 citation statements)

References 1 publication

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“…Jang and Kim [27] found significantly higher levels of allergic mediators such as IL-4, IL-6, and tumor necrosis factor-α in the MEE of the allergic individuals suffering from OM. Sobol et al [28] also found that atopic patients have a significantly higher percentage of T lymphocytes, eosinophils, mast cells, basophils, IL-4, and IL-5 in MEE, and Hurst and Venge [25] reported that mast cells and the mediator tryptase are present in the majority of ears that have chronic effusion. Overall, these results support the hypothesis that the immunopathologic mechanism underlying the development of MEE can be largely a result of the effects of T-helper type 2 (Th2) mediators; thus, the inflammation within the middle ear of many patients is allergic in nature.…”

Section: Role Of Atopymentioning

confidence: 95%

Audiological Investigation of Otitis Media in Children with Atopy

Martines

Bentivegna

2011

Curr Allergy Asthma Rep

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Otitis media (OM) describes an inflammatory process within the middle ear space that is generally associated with accumulation of fluid and that may lead to hearing loss, learning difficulties, and delays in language development. The pathogenesis of OM is multifactorial, involving the adaptive and native immune system, eustachian tube dysfunction, viral and bacterial load, and genetic and environmental factors. The involvement of IgEmediated allergic reactions in the pathogenesis of OM has been suggested by clinical observations of a high prevalence of OM among patients with allergies. Evidence from studies involving tympanometric measurements, audiometric measurements, and otoscopic examination confirms the role of atopy in the development and persistence of OM.

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Section: Role Of Atopymentioning

confidence: 95%

Audiological Investigation of Otitis Media in Children with Atopy

Martines

Bentivegna

2011

Curr Allergy Asthma Rep

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“…The middle ear effusions of atopic patients with OME showed significantly higher levels of eosinophils, T lymphocytes, and IL-4 mRNA+ cells (p<0.01) and significantly lower levels of neutrophils and IFN-γ mRNA+ cells (p<0.01) compared to non-atopic patients with OME (Nguyen et al, 2004). Similarly, in another study, a higher percentage of eosinophils and T lymphocytes, and a higher percentage of cells expressing IL-4 and IL-5 were found among atopic patients with OME (Sobol et al, 2002). Fireman, 1988) www.intechopen.com…”

Section: Pathophysiology Of Ome and Armentioning

confidence: 76%

“…Furthermore, it has been found that a reduction in the size of the lumen in an inflamed E-tube could impede mucociliary function, thus delaying clearance of acute infective middle ear effusion, leading to recurrent OME (Alles et al, 2001). Several studies analyzing middle ear mucosa and effusions in atopic patients with OME have demonstrated that the composition of the inflammatory substrate in acute otitis media is similar to the type I late-phase allergic response seen in other areas of the respiratory tract, such as in AR, chronic RS, and asthma (Nguyen et al, 2004;Sobol et al, 2002;Hurst, 1996). The middle ear effusions of atopic patients with OME showed significantly higher levels of eosinophils, T lymphocytes, and IL-4 mRNA+ cells (p<0.01) and significantly lower levels of neutrophils and IFN-γ mRNA+ cells (p<0.01) compared to non-atopic patients with OME (Nguyen et al, 2004).…”

Section: Pathophysiology Of Ome and Armentioning

confidence: 99%

Comorbidities of Allergic Rhinitis

Han¹,

Rhee²

2012

Allergic Diseases - Highlights in the Clinic, Mechanisms and Treatment

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“…Alguns autores não observaram interação 22,25 , enquanto outros verificaram associação positiva, sendo os fenômenos atópi-cos considerados fatores de risco para as otites [26][27][28] .…”

Section: Resultsunclassified

Secretion of middle ear in infants - occurrence, recurrence and related factors

Saes¹,

Goldberg²,

Montovani³

2005

J Pediatr (Rio J)

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Objective: The present study aimed at evaluating the occurrence and recurrence of middle ear effusion and possible associated factors in the first two years of life of 190 newborns and infants, participants in the interdisciplinary prevention, detection, and intervention program at the Clínica de Educação para Saúde of Universidade do Sagrado Coração.Methods: Newborns and infants were monthly submitted to anamneses, otoscopy, behavioral hearing assessment using sound instruments and pure tones (pediatric audiometry) and tympanometry. Results:The results revealed that 68.4% of infants presented one or more episodes of middle ear effusion during their two first years, with more recurrence among males. Peak occurrence was between four and 12 months of age and, the earlier the first episode, the higher the probability of recurrence. Greatest incidence was during May and August. It was found that, of the variables investigated, the period of exclusive breastfeeding actuated as a protector factor. With respect of risk factors, it was observed that passive smoking, gastro-esophageal reflux and respiratory allergy were related with the recurrences of effusion. Conclusion:Findings revealed the importance of periodic auditory follow-up for infants during their first two years of life, considered to be the critical period of auditory system maturation, during which sensory deprivation can be responsible for damage to the development of speech, language and other auditory abilities.J Pediatr (Rio J). 2005;81(2):133-8: Otoscopy, otitis media, acoustic impedance tests. ResumoObjetivo: O presente estudo objetivou avaliar a ocorrência e recorrência de secreção na orelha média e os possíveis fatores associados, em 190 recém-nascidos e lactentes observados nos 2 primeiros anos de vida, participantes de um programa de prevenção, detecção e intervenção interdisciplinar desenvolvido na Clínica de Educação para Saúde da Universidade do Sagrado Coração.Métodos: Os recém-nascidos e lactentes foram submetidos mensalmente a anamnese, otoscopia, avaliação audiológica comportamental por meio de instrumentos sonoros e tons puros (audiometria pediátrica) e timpanometria.Resultados: Os resultados revelaram que 68,4% dos lactentes apresentaram um ou mais episódios de secreção na orelha média nos 2 primeiros anos, com maior recorrência para o sexo masculino. A idade de maior ocorrência foi entre 4 e 12 meses. Quanto mais cedo ocorreu o primeiro episódio, maior foi a probabilidade de recorrência. Os meses do ano de maior incidência foram de maio a agosto. Das variáveis estudadas, constatou-se que o período de aleitamento materno exclusivo atuou como um fator protetor. Quanto aos fatores de risco, verificou-se que a presença tabagismo passivo, refluxo gastroesofági-co, alergia respiratória esteve relacionada à recorrência de efusão.Conclusão: Os achados revelaram a importância do acompanhamento auditivo periódico para lactentes nos 2 primeiros anos de vida, considerando ser o período crítico para o processo de maturação do sistema auditiv...

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Th2 cytokine expression in atopic children with otitis media with effusion

Cited by 10 publications

References 1 publication

Audiological Investigation of Otitis Media in Children with Atopy

Audiological Investigation of Otitis Media in Children with Atopy

Comorbidities of Allergic Rhinitis

Secretion of middle ear in infants - occurrence, recurrence and related factors

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