Th1-like Cytokine Production Profile and Individual Specific Alterations in TCRBV-gene Usage of T Cells from Newly Diagnosed Type 1 Diabetes Patients after Stimulation with β-cell Antigens

The role of T-cells in the pathogenesis of Type 1 diabetes: From cause to cure

“…In line with the hypothesis that Type 1 diabetes is Th-1 dominated is the observation that the majority of autoreactive T-cell clones produce a Th-1 associated cytokine profile (dominated by interferon-gamma) [91]. Remarkably, the only autoimmune T-cell clone against GAD65 that we isolated from a non-diabetic donor expressed a T-regulatory cytokine profile (IL-10 and interferon-gamma) [81].…”

Autoreactive T cell Responses in Insulin-dependent (Type 1) Diabetes Mellitus. Report of the First International Workshop for Standardization of T cell assays

“…Th2-like; IL-4, IL-5 and IL-10) [9]. This dichotomy is primarily based on animal studies [10,11], but most studies investigating cytokine production of T cells reactive with islet cell autoantigen support this concept for disease pathogenesis in humans [12][13][14]. In support of this notion, recurrent insulitis and -cell destruction was noted in patients receiving a pancreas segment from their nondiabetic twin which occurred in the absence of islet autoantibodies [15].…”

Changes in T-cell receptor VB repertoire in aplastic anemia: effects of different immunosuppressive regimens

“…16 Skewing of the T-cell VB spectrum has also been described for animal models of immunologically mediated diseases such as encephalitis 17,18 and thyroiditis. 19 In humans, expansion of specific CDR3 VB TCR clones has been found in type I diabetes mellitus, 20 thyroiditis, 21 rheumatoid arthritis, [22][23][24] primary biliary cirrhosis, 25 psoriasis, 26,27 or during graft-versus-host disease. 28 TCR VB repertoire analysis has also been performed in patients with AA, 12,13 myelodysplasia (MDS), 29 and paroxysmal nocturnal hemoglobinuria (PNH).…”