Th1 and Th2 cytokine profiles in recurrent aborters with successful pregnancy and with subsequent abortions

Makhseed, M.; Raghupathy, Raj; Azizieh, Fawaz; Omu, Alexander E.; Al-Shamali, Eman; Ashkanani, Laila

doi:10.1093/humrep/16.10.2219

Cited by 248 publications

(203 citation statements)

References 26 publications

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“…Several studies have shown an elevated production of Th2-like cytokines and a decrease in Th1-like cytokines during normal pregnancies compared to pathological pregnancies (Marzi et al 1996;Raghupathy et al 2000;Makhseed et al 2001). The distinct Th2-bias during normal pregnancies showed in these studies could be enhanced as a consequence of a control group including both non-allergic and allergic individuals.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, stimulation with paternal leukocytes increases the secretion of IL-4 by maternal PBMC during normal pregnancy (Ekerfelt et al 1997). Previous studies have reported a high secretion of Th2-like cytokines at the time of delivery of normal pregnancies and increased Th1-like cytokines at the time of a spontaneous abortion (Marzi et al 1996;Makhseed et al 2001). Taken together, a local as well as a systemic Th2-deviation during pregnancy may be necessary for a successful pregnancy and the ability to easily direct immune responses to a Th2-polarized profile may be an evolutionary benefit.…”

Section: Pregnant Women Havementioning

confidence: 99%

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Total and allergen-specific IgE levels during and after pregnancy in relation to maternal allergy

Sandberg

Frykman

Jonsson

et al. 2009

Journal of Reproductive Immunology

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A Th2-skewed immunity may be necessary for a successful pregnancy and the ability to easily direct immune responses to a Th2-polarized profile may be an evolutionary benefit.The Th2-like immunity associated with allergic disease might generate favourable effects on the maintenance of pregnancy, but also on the development of Th2-like immune responses and allergic disease in the offspring. The aim of this study was to explore, by using IgE as a stable proxy for Th2, the Th1/Th2 balance in allergic and non-allergic women by measuring specific and total IgE antibody levels during pregnancy and after delivery.The specific and total IgE antibody levels were determined by ImmunoCAP technology at five occasions during pregnancy (at gestational week 10-12, 15-16, 25, 35 and 39), as well as 2 and 12 months after delivery. Thirty-six women without and 20 women with allergic symptoms were included, of whom 13 were sensitised with allergic symptoms and 30 nonsensitised without allergic symptoms.The levels of total IgE, but not specific IgE, were increased during early pregnancy, as compared to 12 months after delivery, in the sensitised women with allergic symptoms, but not in the non-sensitised women without allergic symptoms (p<0.01). The increase in total IgE levels during early pregnancy only in the sensitised women with allergic symptoms indicates that allergy is associated with an enhanced Th2 deviation during pregnancy.

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Section: Discussionmentioning

confidence: 99%

Section: Pregnant Women Havementioning

confidence: 99%

Total and allergen-specific IgE levels during and after pregnancy in relation to maternal allergy

Sandberg

Frykman

Jonsson

et al. 2009

Journal of Reproductive Immunology

View full text Add to dashboard Cite

show abstract

“…Several similar studies indicate increased Th1-like and decreased Th2-like responses among women with pregnancy losses, whereas women with successful pregnancies tend to have an increased Th2-like response Makhseed et al, 2000;Makhseed et al, 2001;Kwak-Kim et al, 2003). An immune deviation towards Th2 has also been found locally at the maternal-fetal interface in healthy pregnant women , while a decreased local production of Th2 cytokines has been demonstrated in women with unexplained recurrent spontaneous abortions (Piccinni et al, 1998).…”

Section: Introductionmentioning

confidence: 90%

Increased circulating paternal antigen-specific IFN-γ- and IL-4-secreting cells during pregnancy in allergic and non-allergic women

Persson

Ekerfelt

Ernerudh

et al. 2008

Journal of Reproductive Immunology

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“…Makhseed et al (13) found significantly higher levels of the type 1 and lower levels of the type 2 cytokines in supernatants of activated peripheral lymphocytes from women undergoing preterm delivery, than in those from healthy pregnant women. Furthermore, abortion-prone women who proceeded to have successful pregnancy were more Th2 biased than abortionprone women who aborted (14).…”

Section: P Eripheral Lymphocytes From Healthy Pregnant Women Express mentioning

confidence: 99%

Molecular Cloning and Immunologic Characterization of a Novel cDNA Coding for Progesterone-Induced Blocking Factor

Polgar

Kispál

Lachmann

et al. 2003

The Journal of Immunology

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Previous studies from our laboratory showed that the immunomodulatory effects of progesterone are mediated by a 34-kDa protein, named the progesterone-induced blocking factor (PIBF). Lymphocytes of women with threatened abortion fail to produce this factor. Via inducing a Th2 biased cytokine production and blocking of NK activity, PIBF prevents induced pregnancy loss in mice, suggesting that substitution therapy with PIBF could be useful as an alternative treatment of certain forms of recurrent spontaneous abortions. Our study was aimed at mapping the sequence and structure of PIBF coding cDNA and characterizing the encoded protein product. Screening of a human liver cDNA library revealed a 2765-bp clone with a 2271-bp open reading frame. The PIBF1 cDNA encodes a protein of 757 amino acid residues with an 89-kDa predicted molecular mass, which shows no significant amino acid sequence homology with any known protein. PIBF produced via recombinant technique is recognized by the Ab specific for the secreted lymphocyte PIBF Ab, and possesses the biological activities of the secreted lymphocyte PIBF. The full-length PIBF is associated with the nucleus, whereas secretion of shorter forms, such a 34-kDa protein is induced by activation of the cell. The 48-kDa N-terminal part of PIBF is biologically active, and the part of the molecule, responsible for modulating NK activity is encoded by exons 2–4. These data provide an initial step for exploiting the possible diagnostic and therapeutic potential of this immunomodulatory molecule.

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Th1 and Th2 cytokine profiles in recurrent aborters with successful pregnancy and with subsequent abortions

Abstract: We conclude that abortion-prone women who proceed to have successful pregnancy are more Th2-biased than abortion-prone women who abort, and that recurrent aborters who undergo spontaneous abortion have a stronger Th1 bias than aborters who have normal pregnancy.

Cited by 248 publications

References 26 publications

Total and allergen-specific IgE levels during and after pregnancy in relation to maternal allergy

Total and allergen-specific IgE levels during and after pregnancy in relation to maternal allergy

Increased circulating paternal antigen-specific IFN-γ- and IL-4-secreting cells during pregnancy in allergic and non-allergic women

Molecular Cloning and Immunologic Characterization of a Novel cDNA Coding for Progesterone-Induced Blocking Factor

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