TH1 and TH17 interactions in untreated inflamed mucosa of inflammatory bowel disease, and their potential to mediate the inflammation.

Olsen, Trine; Rismo, Renathe; Cui, Ge; Goll, Rasmus; Christiansen, Ingrid; Husebekk, Anne; Florholmen, Jon

doi:10.1093/ibd/17.supplement1.s16c

Cited by 21 publications

(34 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Th17 cells might indicate intestinal dysregulation and the start of proinflammatory processes [49,50], which is compensated by the increased numbers of Tregs, as suggested previously [51]. These findings seem to be in line with the finding of a decreased percentage of Breg in the PP of whey sensitized animals but not in the whey hydrolysate sensitized mice.…”

Section: Discussionsupporting

confidence: 87%

Partially hydrolyzed whey proteins prevent clinical symptoms in a cow's milk allergy mouse model and enhance regulatory T and B cell frequencies

Kiewiet

Esch

Garssen

et al. 2017

Molecular Nutrition Food Res

View full text Add to dashboard Cite

Scope:Partially hydrolyzed cow's milk proteins are used to prevent cow's milk allergy in children. Here we studied the immunomodulatory mechanisms of partial cow's milk hydrolysates in vivo. Methods and results: Mice were sensitized with whey or partially hydrolyzed whey using cholera toxin. Whey-specific IgE levels were measured to determine sensitization and immune cell populations from spleen, mesenteric lymph nodes and Peyer's patches after oral whey administration were measured by flowcytometry. Whey-specific IgE and IgG1 levels in partial whey hydrolysate sensitized animals were enhanced, but challenge did not induce clinical symptoms. This immunomodulatory effect of partial whey hydrolysate was associated with increased regulatory B and T cells in the spleen, together with a prevention of IgM-IgA class switching in the mesenteric lymph nodes and an increased Th1 and activated Th17 in the Peyer's patches. Conclusion: Partial hydrolysate sensitization did not induce whey-induced clinical symptoms, even though sensitization was established. Increased regulatory cell populations in the systemic immune system and a prevention of increased total Th1 and activated Th17 in the intestinal immune organs could contribute to the suppression of allergic symptoms. This knowledge is important for a better understanding of the beneficial effects of hydrolysates.

show abstract

Section: Discussionsupporting

confidence: 87%

Partially hydrolyzed whey proteins prevent clinical symptoms in a cow's milk allergy mouse model and enhance regulatory T and B cell frequencies

Kiewiet

Esch

Garssen

et al. 2017

Molecular Nutrition Food Res

View full text Add to dashboard Cite

show abstract

“…Th17 cells and the related cytokines are important factors in the pathogenesis of IBD, as IL-17A, IL-6 and IL-23 have been observed to increase remarkably in UC and Crohn disease patients. This is seen especially in UC, associating positively with disease activity and clinical grading (8). Research using animal models also has shown that IL-17/IL-23 is critical for IBD development (56,57).…”

Section: Discussionmentioning

confidence: 95%

Heme Oxygenase-1 Ameliorates Dextran Sulfate Sodium-induced Acute Murine Colitis by Regulating Th17/Treg Cell Balance

Zhang

Zhong

et al. 2014

Journal of Biological Chemistry

View full text Add to dashboard Cite

“…The first reports of increased density of IL-17 cells in the inflamed mucosa of IBD came in 2003 (Fujino et al, 2003) and was confirmed by later studies (Kobayashi et al, 2008;Olsen T et al, 2011b). Both IL-17 and IL-23 are correlated to the severity of UC (Olsen T et al, 2011b) and are positive correlated to the response to infliximab .…”

Section: Il-17/il-23mentioning

confidence: 86%

“…Increased levels of TGF-1 are found both in CD and UC (Lawrance et al, 2001;Olsen T et al, 2011b), which are correlated with the severity of disease in CD but not in UC (Olsen T et al, 2011b).…”

Section: Antiinflammatory Cytokines 431 Transforming Growth Factor-βmentioning

confidence: 92%

See 1 more Smart Citation

Clinical, Biological, and Laboratory Parameters as Predictors of Severity of Clinical Outcome and Response to Anti–TNF–Alpha Treatment in Ulcerative Colitis

Olsen¹,

Florholmen²

2011

Ulcerative Colitis - Treatments, Special Populations and the Future

View full text Add to dashboard Cite

TH1 and TH17 interactions in untreated inflamed mucosa of inflammatory bowel disease, and their potential to mediate the inflammation.

Cited by 21 publications

References 0 publications

Partially hydrolyzed whey proteins prevent clinical symptoms in a cow's milk allergy mouse model and enhance regulatory T and B cell frequencies

Partially hydrolyzed whey proteins prevent clinical symptoms in a cow's milk allergy mouse model and enhance regulatory T and B cell frequencies

Heme Oxygenase-1 Ameliorates Dextran Sulfate Sodium-induced Acute Murine Colitis by Regulating Th17/Treg Cell Balance

Clinical, Biological, and Laboratory Parameters as Predictors of Severity of Clinical Outcome and Response to Anti–TNF–Alpha Treatment in Ulcerative Colitis

Contact Info

Product

Resources

About