Th immune response induced by<i>H pylori</i>vaccine with chitosan as adjuvant and its relation to immune protection

Xie, Yong; Zhou, Nan; Gong, Yanfeng; Zhou, Xiao‐Nong; Jiang, Chen; Hu, Sijuan; Lü, Nonghua; Hou, Xiaohua

doi:10.3748/wjg.v13.i10.1547

Cited by 41 publications

(27 citation statements)

References 28 publications

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“…In spite of the promising use of chitosan in the pharmaceutical industry, most of the chitosan researches are directed towards medical applications. For example, some studies showed that chitosan, whether it is used as an immune adjuvant, drug delivery agent or dietary fibre, could effectively promote local immune response and enhance antigen presentation (Porporatto et al, 2005;Xie et al, 2007).…”

Section: Applicationsmentioning

confidence: 99%

Chitosan and its antimicrobial potential – a critical literature survey

Raafat

Sahl

2009

Microbial Biotechnology

709

409

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SummaryChitosan, an aminopolysaccharide biopolymer, has a unique chemical structure as a linear polycation with a high charge density, reactive hydroxyl and amino groups as well as extensive hydrogen bonding. It displays excellent biocompatibility, physical stability and processability. The term ‘chitosan’ describes a heterogenous group of polymers combining a group of physicochemical and biological characteristics, which allow for a wide scope of applications that are both fascinating and as yet uncharted. The increased awareness of the potentials and industrial value of this biopolymer lead to its utilization in many applications of technical interest, and increasingly in the biomedical arena. Although not primarily used as an antimicrobial agent, its utility as an ingredient in both food and pharmaceutical formulations lately gained more interest, when a scientific understanding of at least some of the pharmacological activities of this versatile carbohydrate began to evolve. However, understanding the various factors that affect its antimicrobial activity has become a key issue for a better usage and a more efficient optimization of chitosan formulations. Moreover, the use of chitosan in antimicrobial systems should be based on sufficient knowledge of the complex mechanisms of its antimicrobial mode of action, which in turn would help to arrive at an appreciation of its entire antimicrobial potential.

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Section: Applicationsmentioning

confidence: 99%

Chitosan and its antimicrobial potential – a critical literature survey

Raafat

Sahl

2009

Microbial Biotechnology

709

409

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“…Bivas-Benita et al immunized mice with oral Toxoplasma gondii GRA1 protein and DNA vaccineloaded chitosan particles, and successfully induced specialized anti-GRA1 IgG1 and IgG2a, indicating that it can enhance immune respons to Th1 and Th2 [21]. Xie et al revealed that H. pylori with chitosan solution as an adjuvant can protect against H. pylori infection and induce both Th1 and Th2 type immune response by oral [22]. Therefore, the type of immune response of these CS derivatives requires further investigation.…”

Section: Discussionmentioning

confidence: 99%

Oral Methylated N-Aryl Chitosan Derivatives for Inducing Immune Responses to Ovalbumin

Suksamran¹,

Kowapradit²,

Ngawhirunpat³

et al. 2013

Trop. J. Pharm Res

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“…Chitosan solution and particles had mostly comparable effects and induced Th1 and Th2 immune responses [25]. Chitosan (88.5% DAD, Qisheng Biological Products Limited Company, China) solution was prepared in acetic acid.…”

Section: Chitosan-based Adjuvants: Comparative Preclinical Studiesmentioning

confidence: 99%

Chitosan-based vaccine adjuvants: incomplete characterization complicates preclinical and clinical evaluation

Vasiliev

2014

Expert Review of Vaccines

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A number of preclinical and clinical studies with chitosan-adjuvanted antigen- and DNA-based vaccines have been carried out. Various chitosans and their modifications, in different forms (solutions, powders, gels and particles), have been evaluated with various antigens administered via different routes. Chitosan is a generic name for a wide array of glucosamine-based substances derived from biological sources, and standardization is necessary. However, in most of the studies published to date, molecular weight, viscosity, deacetylation degree and/or purity level (especially endotoxins) are not provided for the initial chitosan substance and/or final formulation and the preparation procedure is not detailed. Evaluation of adjuvant properties is challenging, given that the only available data are insufficient to demonstrate immunogenicity for chitosans with characteristics within certain intervals to elucidate mechanisms of action or to exclude impurities as the active substance. These and other issues of chitosan-based vaccine adjuvants are summarized and a step-by-step evaluation approach for chitosan-based vaccine adjuvants is outlined.

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Th immune response induced byH pylorivaccine with chitosan as adjuvant and its relation to immune protection

Abstract: AIM:To study the immunological protective effect of H pylori vaccine with chitosan as an adjuvant and its mechanism.

Cited by 41 publications

References 28 publications

Chitosan and its antimicrobial potential – a critical literature survey

Chitosan and its antimicrobial potential – a critical literature survey

Oral Methylated N-Aryl Chitosan Derivatives for Inducing Immune Responses to Ovalbumin

Chitosan-based vaccine adjuvants: incomplete characterization complicates preclinical and clinical evaluation

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