Th-1 Lymphocytes Induce Dendritic Cell Tumor Killing Activity by an IFN-γ–Dependent Mechanism

LaCasse, Collin J.; Janikashvili, Nona; Larmonier, Claire B.; Alizadeh, Darya; Hanke, Neale T.; Kartchner, Jessica; Situ, Elaine; Centuori, Sara; Har-Noy, Michael; Bonnotte, Bernard; Katsanis, Emmanuel; Larmonier, Nicolas

doi:10.4049/jimmunol.1101812

Cited by 39 publications

(38 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Because immune cell activities are often responses to external stimulation by other cell types, cocultures of cancer cells and immune cells are frequently used to assay specific immune cell activities, including changes in cytokine production and release [196][197][198], anti-cancer cytotoxic activities [199][200][201], and immune cell maturation and differentiation [202,203]. Interestingly, the communication between cancer cells and immune cells appears to be bidirectional, with immune cells also modulating cancer cell characteristics such as migratory potentials [204,205] and chemokine production [206].…”

Section: Co-cultures With Immune Cellsmentioning

confidence: 98%

Lessons from patient-derived xenografts for better in vitro modeling of human cancer

Choi¹,

Lin²,

Gout³

et al. 2014

Advanced Drug Delivery Reviews

155

134

View full text Add to dashboard Cite

The development of novel cancer therapeutics is often plagued by discrepancies between drug efficacies obtained in preclinical studies and outcomes of clinical trials. The inconsistencies can be attributed to a lack of clinical relevance of the cancer models used for drug testing. While commonly used in vitro culture systems are advantageous for addressing specific experimental questions, they are often gross, fidelity-lacking simplifications that largely ignore the heterogeneity of cancers as well as the complexity of the tumor microenvironment. Factors such as tumor architecture, interactions among cancer cells and between cancer and stromal cells, and an acidic tumor microenvironment are critical characteristics observed in patient-derived cancer xenograft models and in the clinic. By mimicking these crucial in vivo characteristics through use of 3D cultures, co-culture systems and acidic culture conditions, an in vitro cancer model/microenvironment that is more physiologically relevant may be engineered to produce results more readily applicable to the clinic.

show abstract

Section: Co-cultures With Immune Cellsmentioning

confidence: 98%

Lessons from patient-derived xenografts for better in vitro modeling of human cancer

Choi¹,

Lin²,

Gout³

et al. 2014

Advanced Drug Delivery Reviews

155

134

View full text Add to dashboard Cite

show abstract

“…þ Th1 (but not Th2) cells, Th17 cells, and regulatory T cells are capable of inducing the cytotoxic functions of DCs, and IFNg is the major factor responsible for Th1-induced DC tumoricidal activity (3). IFNg also acts as a CTL differentiation signal (4).…”

mentioning

confidence: 99%

Dual Faces of IFNγ in Cancer Progression: A Role of PD-L1 Induction in the Determination of Pro- and Antitumor Immunity

Mandai

Hamanishi

Abiko

et al. 2016

Clinical Cancer Research

317

277

View full text Add to dashboard Cite

show abstract

“…We have demonstrated that in rat and mouse, the cytotoxic activity of DC generated from bone marrow was not mediated by perforin/granzyme B, FasL, TNF-α, or TRAIL, but depended on peroxynitrites, the main metabolite of NO. 54, 68, 69, 72 In these studies, the killing ability of DC generated from iNOS or gp91 knock-out mice was significantly reduced. 68, 69 Independent groups have also reported on the essential role of NO in both mouse 56 and rat 83 bone marrow-derived DC-mediated apoptosis of tumor cells.…”

Section: Ii-principal Aspects Of DC Cytotoxic Functionmentioning

confidence: 83%

Dendritic Cell Tumor Killing Activity and Its Potential Applications in Cancer Immunotherapy

et al. 2013

Self Cite

View full text Add to dashboard Cite

Universally viewed as the sentinels and messengers of the immune system and traditionally referred to as professional antigen presenting cells, dendritic cells (DC) play a fundamental role in antitumor immunity. DC are uniquely equipped with the ability to acquire, process and present tumor-derived antigens to T lymphocytes. They can drive the differentiation of naïve T cells into activated tumor-specific effector lymphocytes. DC also dictate the type and regulate the strength and duration of T cell responses. In addition, they contribute to NK and NKT cell antitumoral function and to B cell-mediated immunity. Besides this cardinal role as orchestrators of innate and adaptive immune responses, many studies have provided evidence that DC can also function as direct cytotoxic effectors against tumors. This less conventional aspect of DC lifestyle has however raised controversy as it relates to the origin of these cells and the induction, regulation and mechanisms underlying their tumoricidal activity. The possible impact of the cytotoxic function of DC on their antigen presenting capability has also been the focus of intensive research. In this review, we examine these questions and discuss the biological significance of this non-traditionalproperty and possible strategies to exploit DC killing potential in cancer immunotherapy.

show abstract

Th-1 Lymphocytes Induce Dendritic Cell Tumor Killing Activity by an IFN-γ–Dependent Mechanism

Cited by 39 publications

References 48 publications

Lessons from patient-derived xenografts for better in vitro modeling of human cancer

Lessons from patient-derived xenografts for better in vitro modeling of human cancer

Dual Faces of IFNγ in Cancer Progression: A Role of PD-L1 Induction in the Determination of Pro- and Antitumor Immunity

Dendritic Cell Tumor Killing Activity and Its Potential Applications in Cancer Immunotherapy

Contact Info

Product

Resources

About