TGFβ signalling pathway impacts brain metastases profiles in locally advanced colorectal cancer
Sven Jacob,
Ilja Balonov,
Vindi Jurinovic
et al.
Abstract:Rationale
Colorectal Cancer (CRC) represents the third most common type of cancer in Germany and the second most common cancer-related cause of death worldwide. Distant metastases are still the main limit for patient survival. While liver metastases as well as peritoneal carcinomatosis can often either be resected or treated with systemic therapy, little options remain for brain metastases. Additionally, a number of studies has already investigated hepatic, peritoneal, pulmonary as well as contin… Show more
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