Abstract:Background: Cholangiocarcinoma (CCA) is a devastating liver cancer characterized by high aggressiveness and resistance to therapy, which results to poor prognosis. Long non-coding RNAs (lncRNAs) and signals imposed by oncogenic pathways, such as transforming growth factor β (TGFβ) frequently contribute to CCA development. Here, we explored novel effectors of TGFβ signalling in CCA.Methods: We performed gene expression profiling to identify TGFβ-regulated genes in CCA cell lines. RNA-sequencing and ATAC-sequenc… Show more
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