TGF-β2-induced circ-PRDM5 regulates migration, invasion, and EMT through the miR-92b-3p/COL1A2 pathway in human lens epithelial cells

CircPRDM5 inhibits the proliferation, migration, invasion, and glucose metabolism of gastric cancer cells by reducing GCNT4 expression in a miR‐485‐3p‐dependent manner

“…Previous data have expounded the roles of circ_0004872, 19 circ_006100, 20 and circ_0008035 21 in GC malignant progression. As demonstrated by Huang et al, circPRDM5 had effects on lens epithelial cell migration and invasion 22 . However, the mechanism of circPRDM5 in GC development has not been reported.…”

“…As demonstrated by Huang et al, circPRDM5 had effects on lens epithelial cell migration and invasion. 22 However, the mechanism of circPRDM5 in GC development has not been reported. This work identified a low expression of circPRDM5 in GC tissues, which was consistent with the previous data.…”

The Single Cell Transcriptional Landscape of Esophageal Adenocarcinoma and Its Modulation by Neoadjuvant Chemotherapy

“…Profound alterations in broblast subpopulations were seen in EAC with a striking increase in two subsets, de ned by expression of COL1A2 and IER2, which were almost completely absent in adjacent normal tissue. COL1A2 promotes epithelia-to-mesenchymal transition (Huang et al, 2022) whilst its knockdown suppresses proliferation and metastasis of EAC cell lines (Li et al, 2020). These populations may therefore represent valuable therapeutic targets whilst additional broblast populations, including myo broblasts and adipogenic subsets, were seen to increase after successful chemotherapy.…”

Zonular and capsular bag disorders: a hypothetical perspective based on recent pathophysiological insights

“…3 Conversion of LECs to myofibroblasts, through activation of signaling factors such as transforming growth factor (TGF), results in fibrotic posterior capsular opacification (PCO). 18,19 Cataract surgery is the only effective means to treat visually significant cataract. It is now well understood that the open capsular bag is not an inert structure and is subjected to long-term pathophysiological changes that are not well understood.…”

“…3 Conversion of LECs to myofibroblasts, through activation of signaling factors such as transforming growth factor (TGF), results in fibrotic posterior capsular opacification (PCO). 18,19…”