TGF-β1 induces HMGA1 expression: The role of HMGA1 in thyroid cancer proliferation and invasion

Zhong, Jing; Liu, Chang; Zhang, Qing Hai; Chen, Ling; Shen, Yingying; Chen, Yajun; Zeng, Xi; Zu, Xuyu; Cao, Renxian

doi:10.3892/ijo.2017.3958

Cited by 32 publications

(26 citation statements)

References 43 publications

(39 reference statements)

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“…[70] Interestingly, combinations of CD complexes with other host/guest motifs in an orthogonal fashion were also examined, for example, with cucurbit [8]uril [71] or bis(sulfonate)calix [4]arene. [72] Wei and co-workers reported ab lock copolymer consisting of blocks of supramolecular polymer and PEG. [73] In this case, a b-CD-ferrocene AB monomer was utilized to form asupramolecular polymer and am onoferrocene end functionalized PEG was utilized as the chain stopper.R edox-responsive micelles and vesicles could be formed from the polymer structures depending on the ratio of the stopper to AB monomer.Asupramolecular polymer solely based on CD, namely supramolecular polymers of a-CD-azides in the solid state,was presented by Sollogoub and co-workers.…”

Section: Supramolecular Daisy Chain Polymersmentioning

confidence: 99%

Dynamic Macromolecular Material Design—The Versatility of Cyclodextrin‐Based Host–Guest Chemistry

2017

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Dynamic and adaptive materials are powerful constructs in macromolecular and polymer chemistry with a wide array of applications in drug delivery, bioactive systems, and self‐healing materials. Very often, dynamic materials are based on carefully tailored cyclodextrin host–guest interactions. The precise incorporation of these host and guest moieties into macromolecular building blocks allows the formation of complex macromolecular structures with predefined functions. Thus, dynamic materials with extraordinary adaptive property profiles—responsive to thermal, chemical, and photonic fields—become accessible. This Review explores the hierarchical formation of dynamic materials and complex macromolecular structures from the molecular via the macromolecular to the colloidal and macroscopic level, with a specific emphasis on the functionality and responsiveness of the assemblies, specifically in biological contexts.

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Section: Supramolecular Daisy Chain Polymersmentioning

confidence: 99%

Dynamic Macromolecular Material Design—The Versatility of Cyclodextrin‐Based Host–Guest Chemistry

2017

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“…For example, the association between CHI3L1 and transforming growth factor β1 (TGFB1) in TC was identified. YKL-40, also known as chitinase-3-like protein 1 (CHI3L1), is a secreted glycoprotein that binds to interleukin-13 receptor α2 (IL-13Rα2) and subsequently stimulates the production of TGF-β1 (27), a key molecule in thyroid carcinogenesis and considered as a new prognostic and therapeutic target for TC (28,29). The details for all other associations are presented in Fig.…”

Section: Genes Commonly Affected By the Process Of Aging And By The Cmentioning

confidence: 99%

Aging‑associated genes TNFRSF12A and CHI3L1 contribute to thyroid cancer: An evidence for the involvement of hypoxia as a driver

et al. 2020

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The prevalence of thyroid cancer (TC) is high in the elderly. The present study was based on the hypothesis that genes, which have increased activity with aging, may play a role in the development of TC. A large-scale literature-based data analysis was conducted to explore the genes that are implicated in both TC and aging. Subsequently, a mega-analysis of 16 RNA expression datasets (1,222 samples: 439 healthy controls, and 783 patients with TC) was conducted to test a set of genes associated with aging but not TC. To uncover a possible link between these genes and TC, a functional pathway analysis was conducted, and the results were validated by analysis of gene co-expression. A multiple linear regression (MLR) model was employed to study the possible influence of sample size, population region and study age on the gene expression levels in TC. A total of 262 and 816 genes were identified to have increased activity with aging and TC, respectively; with a significant overlap of 63 genes (P<3.82x10-35). The mega-analysis revealed two aging-associated genes (CHI3L1 and TNFRSF12A) to be significantly associated with TC (P<2.05x10-8), and identified the association with multiple hypoxia-driven pathways through functional pathway analysis, also confirmed by the co-expression analysis. The MLR analysis identified population region as a significant factor contributing to the expression levels of CHI3L1 and TNFRSF12A in TC samples (P<3.24x10-4). The determination of genes that promote aging was warranted due to their possible involvement in TC. The present study suggests CHI3L1 and TNFRSF12A as novel common risk genes associated with both aging and TC.

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“…Moreover, HMGA1 can modulate gene expression by altering the chromatin structure and orchestrating the assembly of transcription factor complexes to augment target gene promoter activity (42). Furthermore, HMGA1 markedly facilitates the proliferation of several types of cancer cells, such as pancreatic cancer (36), breast cancer (47), ovarian cancer (48), colon cancer (49) and thyroid cancer (21). Additionally, cyclin D1 also regulates cyclin-dependent kinase (CDK)4 and CDK6 to promote cell cycle transition from the G1 to the S phase (50-52).…”

Section: Disscussionmentioning

confidence: 99%

“…High-mobility group A1 (HMGA1) is a transcription factor which plays a crucial role in regulation of gene expression and biological process (18,19). Emerging evidence has indicated the significant upregulation of HMGA1 expression in several malignant types of cancer, such as bladder cancer, thyroid cancer and NSCLC (20)(21)(22), and the overexpression of HMGA1 has also been shown to positively correlate with the cell proliferation and malignant status of NSCLC (23,24). Reportedly, cyclin D1 is widely overexpressed in certain types of human cancer, and several growth factors, such as epidermal growth factor (EGF) markedly enhance cancer cell proliferation by increasing cyclin D1 expression (25,26).…”

Section: Introductionmentioning

confidence: 99%

IL‑17 induces NSCLC A549 cell proliferation via the upregulation of HMGA1, resulting in an increased cyclin D1 expression

Zhao

Zhang

et al. 2018

Int J Oncol

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Non-small cell lung cancer (NSCLC) is considered to be an inflammation-associated carcinoma. Although interleukin‑17 (IL‑17) production contributes to the proliferation and growth of NSCLC, the mechanisms underlying IL‑17-induced NSCLC cell proliferation have not been fully elucidated. In the present study, by using ELISA and immunohistochemical analyses, we first found that the expression levels of IL‑17, IL‑17 receptor (IL‑17R), high-mobility group A1 (HMGA1) and cyclin D1 were elevated in the samples of patients with NSCLC. Subsequently, by RT-qPCR, western blot analysis and cell proliferation assay in vitro, we revealed that stimulation with recombinant human IL‑17 (namely IL‑17A) markedly induced the expression of HMGA1 and cyclin D1 in the A549 cells (a human lung adenocarcinoma cell line) and promoted cell proliferation. Furthermore, luciferase reporter and ChIP assays confirmed that upregulated HMGA1 directly bound to the cyclin D1 gene promoter and activated its transcription. Notably, the response element of HMGA1 binding to the cyclin D1 promoter was disclosed for the first time, at least to the best of our knowledge. Taken together, our findings indicate that the IL‑17/HMGA1/cyclin D1 axis plays an important role in NSCLC cell proliferation and may provide new insight into NSCLC pathogenesis and may thus aid in the development of novel therapeutic targets for NSCLC.

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TGF-β1 induces HMGA1 expression: The role of HMGA1 in thyroid cancer proliferation and invasion

Cited by 32 publications

References 43 publications

Dynamic Macromolecular Material Design—The Versatility of Cyclodextrin‐Based Host–Guest Chemistry

Dynamic Macromolecular Material Design—The Versatility of Cyclodextrin‐Based Host–Guest Chemistry

Aging‑associated genes TNFRSF12A and CHI3L1 contribute to thyroid cancer: An evidence for the involvement of hypoxia as a driver

IL‑17 induces NSCLC A549 cell proliferation via the upregulation of HMGA1, resulting in an increased cyclin D1 expression

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