TGF-β1 gene polymorphism is a risk factor for renal dysfunction in heart transplant recipients

Lácha, J; Hubacek, Jaroslav A.; Viklický, Ondřej; Málek, I; Hutchinson, I. V.; Vı́tko, Štefan

doi:10.1016/s0041-1345(00)02596-3

Cited by 18 publications

(13 citation statements)

References 12 publications

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“…Our data are in contrast to the few other studies that have investigated the impact of gene variants on renal dysfunction in cardiac transplant recipients. 13,14 Baan et al 13 and Lacha et al 14 found an association with TGF-␤1 gene variants. However, both of their investigations were designed as association studies.…”

Section: Discussionmentioning

confidence: 99%

“…They have been limited to the arginine coding allele (p.R25P) and the leucin or proline coding allele (p.L10P) of the TGF-␤1 gene. 13,14 Therefore, we performed a casecontrol study to determine whether single nucleotide polymorphisms of genes encoding for proteins that are important for CNI action and metabolism have an impact on the development of renal insufficiency.…”

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confidence: 99%

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No Association Between Single Nucleotide Polymorphisms and the Development of Nephrotoxicity After Orthotopic Heart Transplantation

Klauke

Wirth

Zittermann

et al. 2008

The Journal of Heart and Lung Transplantation

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

No Association Between Single Nucleotide Polymorphisms and the Development of Nephrotoxicity After Orthotopic Heart Transplantation

Klauke

Wirth

Zittermann

et al. 2008

The Journal of Heart and Lung Transplantation

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“…Two recent studies (35,36) on hearttransplanted patients suggest that the polymorphism of a TGF-ß1 gene can be involved in the susceptibility to the nephrotoxic effects of cyclosporine. TGF-ß1 is a pro-fibrotic cytokine.…”

Section: Discussionmentioning

confidence: 99%

Determination of renal function in long-term heart transplant patients by measurement of urinary retinol-binding protein levels

Chinen

Câmara

Nishida

et al. 2006

Braz J Med Biol Res

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Significant improvements have been noted in heart transplantation with the advent of cyclosporine. However, cyclosporine use is associated with significant side effects, such as chronic renal failure. We were interested in evaluating the incidence of long-term renal dysfunction in heart transplant recipients. Fifty-three heart transplant recipients were enrolled in the study. Forty-three patients completed the entire evaluation and follow-up. Glomerular (serum creatinine, creatinine clearance measured, and creatinine clearance calculated) and tubular functions (urinary retinol-binding protein, uRBP) were reanalyzed after 18 months. At the enrollment time, the prevalence of renal failure ranged from 37.7 to 54% according to criteria used to define it (serum creatinine ≥1.5 mg/dL and creatinine clearance <60 mL/min). Mean serum creatinine was 1.61 ± 1.31 mg/dL (range 0.7 to 9.8 mg/dL) and calculated and measured creatinine clearances were 67.7 ± 25.9 and 61.18 ± 25.04 mL min -1 (1.73 m 2 ) -1 , respectively. Sixteen of the 43 patients who completed the follow-up (37.2%) had tubular dysfunction detected by increased levels of uRBP (median 1.06, 0.412-6.396 mg/dL). Eleven of the 16 patients (68.7%) with elevated uRBP had poorer renal function after 18 months of followup, compared with only eight of the 27 patients (29.6%) with normal uRBP (RR = 3.47, P = 0.0095). Interestingly, cyclosporine trough levels were not different between patients with or without tubular and glomerular dysfunction. Renal function impairment is common after heart transplantation. Tubular dysfunction, assessed by uRBP, correlates with a worsening of glomerular filtration and can be a useful tool for early detection of renal dysfunction.

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“…In addition, recipients with a genotype predictive of high TNFa production experienced more steroid-resistant rejections [5,6]. Whereas Burlingham et al concluded from the results of an experimental case study that a high responder transforming growth factor beta one (TGFb1) genotype may correlate with the induction of tolerance following renal transplantation [7], Lacha et al found in a study of 175 heart transplants that the high producer TGFb1 genotype was associated with progression of renal insufficiency [8]. In two studies of 101 and 169 patients, respectively, Pelletier et al and Poli et al did not find a correlation between TGFb1 genotype and kidney graft rejection [6,9].…”

Section: Introductionmentioning

confidence: 99%

Relevance of IL10, TGFβ1, TNFα, and IL4Rα Gene Polymorphisms in Kidney Transplantation: A Collaborative Transplant Study Report

Mytilineos¹,

Laux

Opelz

2004

American Journal of Transplantation

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Single nucleotide polymorphisms (SNPs) of cytokine genes have been shown to influence cytokine plasma levels. Cytokines are important mediators during organ graft rejection. It was reported that certain cytokine genotypes are associated with improved kidney graft survival. In the present study, SNPs within the IL10 promoter gene, the first exon of the TGFb1 gene, the TNFa promoter gene, and the IL4Ra gene were analyzed in 2298 first and 1901 repeat cadaver kidney recipients. We found no significant effect on the survival rate of first grafts. Among retransplants, we observed that recipients who were homozygous for the high TNFa producer genotype −308 A had a significantly lower graft survival rate than patients who were carriers of the low producer genotype −308 G (at 3 years: 63.0% vs. 79.5%; p corrected = 0.0116). The results of this large-scale study suggest that IL10, TGFb1, TNFa , and IL4Ra cytokine genotypes do not affect the survival of primary kidney grafts. The outcome of retransplants appears to be affected by TNFa genotypes only.

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TGF-β1 gene polymorphism is a risk factor for renal dysfunction in heart transplant recipients

Cited by 18 publications

References 12 publications

No Association Between Single Nucleotide Polymorphisms and the Development of Nephrotoxicity After Orthotopic Heart Transplantation

No Association Between Single Nucleotide Polymorphisms and the Development of Nephrotoxicity After Orthotopic Heart Transplantation

Determination of renal function in long-term heart transplant patients by measurement of urinary retinol-binding protein levels

Relevance of IL10, TGFβ1, TNFα, and IL4Rα Gene Polymorphisms in Kidney Transplantation: A Collaborative Transplant Study Report

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