TGF-Β1 &amp; PNPLA3 Genetic Variants and the Risk of Hepatic Fibrosis and HCC in Egyptian Patients with HCV-Related Liver Cirrhosis

Nomair, Azhar Mohamed; Kandil, Lamia Said; Nomeir, Hanan Mohamed; Kandil, Noha Said

doi:10.31557/apjcp.2021.22.10.3317

Cited by 6 publications

(5 citation statements)

References 52 publications

(46 reference statements)

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“…Several studies that examined the TGFB1 -509C/T polymorphism in HCV infection did not quantify viral load, although variations in viral load have been linked to another polymorphism in the TGF-β1 gene [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30]. As seen in this review, TGF-β1 was considerably higher in patients with HCV infection and in people with the TT genotype from both the control and HCV groups.…”

Section: Discussionmentioning

confidence: 73%

“… Studies by de Brito et al [ 20 ], Larijani et al [ 21 ], Mohy and Fouad [ 22 ], Nomair et al [ 23 ], Radwan et al [ 24 ], Romani et al [ 25 ], Suzuki et al [ 26 ], Wang et al [ 27 ]. …”

Section: Reviewmentioning

confidence: 99%

“…Mohy and Fouad found that the 509 CC and TT alleles were significantly more expressed in cirrhotic patients than non-cirrhotic group [ 22 ]. Nomair et al found that both TGF-β1 levels and GG allele frequency were significantly higher in the cirrhosis patients than in the control group [ 23 ]. Radwan et al found that the frequencies of TGF-β1-509 TT, TNF-α-308 AA, and GA alleles were significantly higher in cirrhotic and HCC groups [ 24 ].…”

Section: Reviewmentioning

confidence: 99%

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Association of TGF-β1 Polymorphism and TGF-β1 Levels With Chronic Hepatitis C and Cirrhosis: A Systematic Review and Meta-Analysis

Punia¹,

Agrawal²,

Bharti³

et al. 2023

Cureus

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Despite the extensive research conducted on the relationship between transforming growth factor-beta 1 (TGF-β1) polymorphisms and levels and the onset and development of liver disease, there are still certain gaps that need to be addressed. To address these gaps and provide a comprehensive overview of the current knowledge, this review aimed to identify relevant published research on TGF-β1/TGF-β1 polymorphism, TGF-β1/TGF-β1 levels, and their associations with cirrhosis and hepatitis C. The synthesis of available data was performed to further enhance our understanding in this area. Adopting the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, a search strategy was implemented across several online databases to search for relevant articles as per the defined selection criterion. Eight studies were selected after the completion of the search strategy. Of the eight studies, five revealed a considerably high level of TGF-β1 in patients who had hepatitis C virus (HCV) and liver cirrhosis caused by hepatocellular carcinoma (HCC). The forest plot analysis showed a statistically significant impact of TGF-β1 polymorphism and levels on the incidence of hepatic cirrhosis and hepatitis C, with an odds ratio (OR) of 0.65 and a risk ratio (RR) of 0.76. The heterogeneity test showed a high level of heterogeneity at 94% and 95% for OR and RR, respectively, but the overall effect was significant with P < 0.01 for both measures. According to the results obtained, the authors concluded that TGF-β1 polymorphism and its associated levels should be taken into account while developing preventive and therapeutic approaches for hepatic cirrhosis and hepatitis C.

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Section: Discussionmentioning

confidence: 73%

“… Studies by de Brito et al [ 20 ], Larijani et al [ 21 ], Mohy and Fouad [ 22 ], Nomair et al [ 23 ], Radwan et al [ 24 ], Romani et al [ 25 ], Suzuki et al [ 26 ], Wang et al [ 27 ]. …”

Section: Reviewmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

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Association of TGF-β1 Polymorphism and TGF-β1 Levels With Chronic Hepatitis C and Cirrhosis: A Systematic Review and Meta-Analysis

Punia¹,

Agrawal²,

Bharti³

et al. 2023

Cureus

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“…The hepatic inflammation-fibrosis-cancer trajectory is a typical development process after HBV infection (Nomair et al, 2021).…”

Section: Hepatitis B Virus Aggravates Inflammation and Hepatic Fibros...mentioning

confidence: 99%

A double-edged sword: The HBV-induced non-coding RNAs alterations in hepatocellular carcinoma

LIU¹,

Diao²

2023

Biocell

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Non-coding RNAs are speculated to exert important regulatory functions at the level of gene expression, oncogenesis, and many other pathologies. Hepatitis B virus (HBV) infection is a leading cause of hepatocellular carcinoma (HCC), and some studies have shown that the expression of non-coding RNAs has an assignable effect on the development of HBV-induced HCC. In this context, the functions and molecular mechanisms of the HBVinduced non-coding RNA expression in the development of hepatoma have attracted increasing attention. This review covers the progress in the exploration of the relationship between HBV-induced hepatoma and non-coding RNA expression, cataloging the recent reports about the roles of non-coding RNAs in HBV-induced hepatoma into five classes, including (1) modulation of metabolism in hepatic cancer, (2) aggravation of inflammation and hepatic fibrosis, (3) alteration of the tumor immune microenvironment, (4) non-coding RNA N6-methyladenosine modification, and a seemingly opposite process, (5) the suppression of the progression of HBV-related HCC. All evidence supports non-coding RNAs as promising novel targets for the early diagnosis and treatments for HCC.

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“…Patatin-like phospholipase domain-containing 3 gene ( PNPLA3 ), also known as adiponectin, encodes a transmembrane protein composed of 481 amino acids and is expressed on the hepatocyte membrane, which can regulate lipid metabolism, inflammatory mediators and so on [ 6 , 7 ]. PNPLA3 , located on the long arms (q) (22q.13.31) of human chromosome 22, belongs to the patatin-like phospholipase family and is highly expressed in liver and fat [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Contribution of PNPLA3 gene polymorphisms to hepatocellular carcinoma susceptibility in the Chinese Han population

Gong

et al. 2022

BMC Med Genomics

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Objectives The purpose of this study was to investigate the association of PNPLA3 single nucleotide polymorphisms (SNPs) (rs738409 C > G, rs3747207 G > A, rs4823173 G > A, and rs2896019 T > G) with hepatocellular carcinoma (HCC) susceptibility. Methods This case–control study included 484 HCC patients and 487 controls. Logistic regression analysis was performed to study the associations of PNPLA3 gene polymorphisms with HCC susceptibility, and odds ratios with their corresponding 95% confidence intervals were calculated to evaluate these correlations. Results In the overall analysis, we found that the G allele (OR = 1.25, 95% CI = 1.04–1.50, p = 0.018, false discovery rate (FDR)-p = 0.035) and GG genotype (OR = 1.59, 95% CI = 1.06–2.39, p = 0.024, FDR-p = 0.048) of rs2896019 were significantly associated with increased HCC susceptibility. In stratified analysis, we found that all four SNPs were related to increased HCC susceptibility in subjects aged > 55 years. In haplotype analysis, the GAAG haplotype was significantly associated with increased HCC susceptibility (OR = 1.25, 95% CI = 1.03–1.53, p = 0.023, FDR-p = 0.046). Besides, we noticed that rs738409 was significantly correlated with alpha-fetoprotein (AFP) (p = 0.007), and HCC patients with the GG genotype had a higher level of AFP. Conclusions Our study suggested that PNPLA3-rs2896019 was significantly associated with an increased susceptibility to HCC.

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TGF-Β1 & PNPLA3 Genetic Variants and the Risk of Hepatic Fibrosis and HCC in Egyptian Patients with HCV-Related Liver Cirrhosis

Cited by 6 publications

References 52 publications

Association of TGF-β1 Polymorphism and TGF-β1 Levels With Chronic Hepatitis C and Cirrhosis: A Systematic Review and Meta-Analysis

Association of TGF-β1 Polymorphism and TGF-β1 Levels With Chronic Hepatitis C and Cirrhosis: A Systematic Review and Meta-Analysis

A double-edged sword: The HBV-induced non-coding RNAs alterations in hepatocellular carcinoma

Contribution of PNPLA3 gene polymorphisms to hepatocellular carcinoma susceptibility in the Chinese Han population

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