TGF-β related genes in development

Wall, Nancy A.; Hogan, Brigid L.M.

doi:10.1016/0959-437x(94)90066-c

Cited by 97 publications

(52 citation statements)

References 56 publications

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“…Basic FGF was demonstrated to increase proliferation rate and life span in rabbit, dog and human MSC while maintaining their potential to differentiate towards fat, cartilage and bone [133,134]. The family of BMPs has a pivotal role in prechondrogenic condensations and the transition of chondroprogenitor cells into chondrocytes [135][136][137]. Specifically, BMP-2 is expressed in the condensing mesenchyme of the developing limb [138], and regulates chondrogenic development of mesenchymal progenitors [139][140][141].…”

Section: Vivomentioning

confidence: 99%

Cartilage tissue engineering for degenerative joint disease☆

Nešić

Whiteside

Brittberg

et al. 2006

Advanced Drug Delivery Reviews

210

156

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Pain in the joint is often due to cartilage degeneration and represents a serious medical problem affecting people of all ages. Although many, mostly surgical techniques, are currently employed to treat cartilage lesions, none has given satisfactory results in the long term. Recent advances in biology and material science have brought tissue engineering to the forefront of new cartilage repair techniques. The combination of autologous cells, specifically designed scaffolds, bioreactors, mechanical stimulations and growth factors together with the knowledge that underlies the principles of cell biology offers promising avenues for cartilage tissue regeneration. The present review explores basic biology mechanisms for cartilage reconstruction and summarizes the advances in the tissue engineering approaches. Furthermore, the limits of the new methods and their potential application in the osteoarthritic conditions are discussed.

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Section: Vivomentioning

confidence: 99%

Cartilage tissue engineering for degenerative joint disease☆

Nešić

Whiteside

Brittberg

et al. 2006

Advanced Drug Delivery Reviews

210

156

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“…Members of the transforming growth factor-b (TGF-b) family have been implicated in the regulation of cell growth, differentiation, apoptosis, adhesion, and motility (Roberts and Sporn, 1990;Wall and Hogan, 1994;Moses and Serra, 1996). Abnormal activation or inhibition of these TGF-b regulated processes is implicated in many diseases including cancer.…”

Section: Introductionmentioning

confidence: 99%

Loss of the Smad3 expression increases susceptibility to tumorigenicity in human gastric cancer

et al. 2003

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“…BMP2 and BMP4 are closely related, highly conserved homologs of the Drosophila protein decapentaplegic. Decapentaplegic plays multiple roles in Drosophila development (1,2), and BMP4 is essential for mesoderm formation and patterning during mouse development (3). BMP4 Ϫ/Ϫ embryos die between embryonic day (E) 6.5 and E9.5 (3), and BMP4 is important in cartilage and bone formation (4) and as a negative regulator of neural induction (5).…”

mentioning

confidence: 99%

Bone Morphogenetic Protein 2/4 Signaling Regulates Early Thymocyte Differentiation

Hager-Theodorides

Outram

Shah

et al. 2002

The Journal of Immunology

111

131

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Bone morphogenetic protein (BMP)2 and BMP4 are involved in the development of many tissues. In this study, we show that BMP2/4 signaling is involved in thymocyte development. Our data suggest that termination of BMP2/4 signaling is necessary for differentiation of CD44+CD25−CD4−CD8− double negative (DN) cells along the T cell lineage. BMP2 and BMP4 are produced by the thymic stroma and the requisite BMP receptor molecules (BMPR-1A, BMPR-1B, BMPR-II), and signal transduction molecules (Smad-1, -5, -8, and -4) are expressed by DN thymocytes. BMP4 inhibits thymocyte proliferation, enhances thymocyte survival, and arrests thymocyte differentiation at the CD44+CD25− DN stage, before T cell lineage commitment. Neutralization of endogenous BMP2 and BMP4 by treatment with the antagonist Noggin promotes and accelerates thymocyte differentiation, increasing the expression of CD2 and the proportion of CD44−CD25− DN cells and CD4+CD8+ double-positive cells. Our study suggests that the BMP2/4 pathway may function in thymic homeostasis by regulating T cell lineage commitment and differentiation.

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TGF-β related genes in development

Cited by 97 publications

References 56 publications

Cartilage tissue engineering for degenerative joint disease☆

Cartilage tissue engineering for degenerative joint disease☆

Loss of the Smad3 expression increases susceptibility to tumorigenicity in human gastric cancer

Bone Morphogenetic Protein 2/4 Signaling Regulates Early Thymocyte Differentiation

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