2021
DOI: 10.1186/s12891-021-04509-w
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TGF-β regulates nerve growth factor expression in a mouse intervertebral disc injury model

Abstract: Background Intervertebral disc (IVD) degeneration is a major cause of low back pain (LBP). Following disc injury, nerve growth factor (NGF) concentrations rise in IVDs, and anti-NGF therapy has been shown to attenuate LBP in humans. Increased levels of tumor necrosis factor-α (TNF-α) and transforming growth factor-β (TGF-β) in degenerative IVDs and in in vitro studies suggest that these factors promote NGF production. However, whether these factors regulate NGF in vivo remains unclear. Thus, we… Show more

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Cited by 13 publications
(9 citation statements)
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“…We previously reported that TGF-β is dominantly expressed in disc cells compared to macrophages in degenerative IVDs in mice. 38 In our present study, chondrocytic cells in degenerative IVD were positive for TGF-β. Therefore, chondrocytic cell-derived TGF-β may modulate M2 polarization in degenerative IVDs.…”
Section: Discussionsupporting
confidence: 59%
“…We previously reported that TGF-β is dominantly expressed in disc cells compared to macrophages in degenerative IVDs in mice. 38 In our present study, chondrocytic cells in degenerative IVD were positive for TGF-β. Therefore, chondrocytic cell-derived TGF-β may modulate M2 polarization in degenerative IVDs.…”
Section: Discussionsupporting
confidence: 59%
“…TGF β (transforming growth factor-beta) belongs to a group of growth factors that are members of the TGF superfamily and are important in mediating various cellular functions [ 51 ]. It has been demonstrated to play a key regulatory role in the molecular biology of IDD [ 52 , 53 ]. However, the benefits and drawbacks of the TGF- β signaling pathway for IDD function remain controversial [ 54 ].…”
Section: Discussionmentioning
confidence: 99%
“…From this point of view, finding a suitable animal model appears difficult. Most studies [37][38][39] on disc degeneration have therefore used surgically created animal models to cause similar changes. However, IVD degeneration also reveals that age-related changes in IVD structure might be more directly reflected in quadrupeds.…”
Section: Discussionmentioning
confidence: 99%