TGF-β-Based Therapies for Treating Ocular Surface Disorders
Fernando T. Ogata,
Sudhir Verma,
Vivien J. Coulson-Thomas
et al.
Abstract:The cornea is continuously exposed to injuries, ranging from minor scratches to deep traumas. An effective healing mechanism is crucial for the cornea to restore its structure and function following major and minor insults. Transforming Growth Factor-Beta (TGF-β), a versatile signaling molecule that coordinates various cell responses, has a central role in corneal wound healing. Upon corneal injury, TGF-β is rapidly released into the extracellular environment, triggering cell migration and proliferation, the d… Show more
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