TGF-B signaling pathway, ER-a and the heterogeneity of breast cancer risk among hispanic and non-hispanic white women.

Plate‐Induced tumors of BALB/3T3 cells exhibiting foci of differentiation into pericytes, chondrocytes, and fibroblasts

“…It has been shown, however, that BALB/3T3 and related mouse embryo cell lines are not "normal" because they will produce tumors if implanted subcutaneously to glass beads t o small plastic plates [l-51. The observation that plate-induced BALB/3T3 and C3H/lOT% tumors arising in different animals exhibited transplantation-rejection antigens that were unique for each individual tumor [2,4] strongly suggests that the plate-induced tumors did not develop from tumorigenic cells already present in the cell monolayers at the time of subcutaneous implantation on plastic plates. This evidence favors the view that BALB/ 3T3 and C3H/IOT% and related mouse embryo cells are preneoplastic.…”