TG/HDL, Non-HDL, and TyG index as predictive parameters for CVDs in uncontrolled diabetic patients better than LDL-C and LDL/HDL ratio

Abstract

Type 2 diabetes is widely associated with dyslipidaemia in uncontrolled patients. Prediction parameters of cardiovascular diseases have controversial issue. Therefore, the aims of this study were to investigate i) the possibility of prediction of cardiovascular diseases (CVDs) from lipoprotein ratios (TG/HDL ratio, TC/HDL ratio) and/or non-HDL level ii) the role of TyG index in prediction of CVDs in uncontrolled DM. 107 participants were recruited in this study, 34 participants were DM (32%; control) and 73 participants were uncontrolled DM (68%). HbA1c, Fasting plasma glucose, lipid profile were measured. In this study the mean age of control DM group was (50.2±2.2), and (54.1±1.6) for uncontrolled group. Weight was higher in uncontrolled DM group. FPG and HbA1c were higher in uncontrolled group. Neither LDL-C nor LDL/HDL ratio showed a significant difference between controlled DM and Uncontrolled DM. TG/HDL was elevated in uncontrolled DM. non-HDL and TyG index were significantly increased in the uncontrolled group. We concluded that neither LDL-C nor LDL/HDL ratio have a predictive role for CVDs as proposed previously. TG/HDL ratio, non-HDL, and TyG index pointed out as a useful predictive parameters for CVDs in uncontrolled T2D.

High-Molecular weight Adiponectin, and TyG-BMI, are better predictive markers than TyG index and HbA1c to predict pre-diabetes in overweight adults

“…It has been reported that TyG index and TG/HDL ratio are good parameters to predict insulin resistance (14,17,18) . Those parameters were slightly increased in the overweight group, while FPG, BMI, TyG-BMI and PI showed highly differences in the overweight group.…”

“…A low level of adipo-nectin has been reported in obese and high-fat-diet rodents (13) .Triglyceride glucose index (TyG index) is one of the parameters that is used to measure insulin resistance (14)(15)(16) . It is also used as predictive parameter to predict T2D in pre-diabetes in obese patients (17) , and it is also a predictor for cardiovascular disease in T2D (18) . Barry et al 2016 reported that measuring of HbA1c is not sensitive or specific and fasting plasma glucose level is also not sensitive but specific for prediabetes (19) .…”