TG/HDL-C ratio predicts in-hospital mortality in patients with acute type A aortic dissection

Lin, Yanjuan; Lin, Jingdong; Peng, Yanchun; Li, Sailan

doi:10.1186/s12872-022-02793-5

Cited by 7 publications

(3 citation statements)

References 34 publications

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“…The effect of BMI on perioperative mortality of ATAAD was extracted from 12 studies which included 5,522 patients. Single-center studies in China observed that mean BMI was associated with perioperative mortality of ATAAD, including 30-days mortality [ 21 ] (HR = 1.13, 95% CI: 1.03–1.25), in-hospital mortality [ 19 , 20 , 23 , 25 ] (OR = 1.15, 95% CI: 1.03–1.29, OR = 1.32, 95% CI: 1.03–1.70, HR = 2.61, 95% CI: 1.30–5.22 and OR = 1.09, 95% CI: 1.04–1.15). Consistently, different perioperative mortality of ATAAD was found between different BMI categories.…”

Section: Resultsmentioning

confidence: 99%

Impact of body mass index on perioperative mortality of acute stanford type A aortic dissection: a systematic review and meta-analysis

Song,

Liu,

et al. 2023

BMC Cardiovasc Disord

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Background Obesity may increase perioperative mortality of acute Stanford type A aortic dissection (ATAAD). However, the available evidence was limited. This study aimed to systematically review published literatures about body mass index (BMI) and perioperative mortality of ATAAD. Methods Electronic literature search was conducted in PubMed, Medline, Embase and Cochrane Library databases. All observational studies that investigated BMI and perioperative mortality of ATAAD were included. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using a random-effects model. Meta-regression analysis was performed to assess the effects of different clinical variables on BMI and perioperative mortality of ATAAD. Sensitivity analysis was performed to determine the sources of heterogeneity. Egger’s linear regression method and funnel plot were used to determine the publication bias. Results A total of 12 studies with 5,522 patients were eligible and included in this meta-analysis. Pooled analysis showed that perioperative mortality of ATAAD increased by 22% for each 1 kg/m2 increase in BMI (OR = 1.22, 95% CI: 1.10–1.35). Univariable meta-regression analysis indicated that age and female gender significantly modified the association between BMI and perioperative mortality of ATAAD in a positive manner (meta-regression on age: coefficient = 0.04, P = 0.04; meta-regression on female gender: coefficient = 0.02, P = 0.03). Neither significant heterogeneity nor publication bias were found among included studies. Conclusions BMI is closely associated with perioperative mortality of ATAAD. Optimal perioperative management needs to be further explored and individualized for obese patient with ATAAD, especially in elderly and female populations. Trial registration PROSPERO (CRD42022358619). Graphical Abstract BMI and perioperative mortality of ATAAD.

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Section: Resultsmentioning

confidence: 99%

Impact of body mass index on perioperative mortality of acute stanford type A aortic dissection: a systematic review and meta-analysis

Song,

Liu,

et al. 2023

BMC Cardiovasc Disord

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“…Vascular inflammation also contributes to the development of abdominal aortic aneurysm (AAA), and HDL composition and functions have been reported to be altered in the disease [ 292 , 293 ]. The use of modified HDL as a surrogate biomarker of oxidative stress in AAA has also been proposed [ 294 ].…”

Section: Future Outlook and Perspectivesmentioning

confidence: 99%

A Current Update on the Role of HDL-Based Nanomedicine in Targeting Macrophages in Cardiovascular Disease

Rani

Marsche

2023

Pharmaceutics

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High-density lipoproteins (HDL) are complex endogenous nanoparticles involved in important functions such as reverse cholesterol transport and immunomodulatory activities, ensuring metabolic homeostasis and vascular health. The ability of HDL to interact with a plethora of immune cells and structural cells places it in the center of numerous disease pathophysiologies. However, inflammatory dysregulation can lead to pathogenic remodeling and post-translational modification of HDL, rendering HDL dysfunctional or even pro-inflammatory. Monocytes and macrophages play a critical role in mediating vascular inflammation, such as in coronary artery disease (CAD). The fact that HDL nanoparticles have potent anti-inflammatory effects on mononuclear phagocytes has opened new avenues for the development of nanotherapeutics to restore vascular integrity. HDL infusion therapies are being developed to improve the physiological functions of HDL and to quantitatively restore or increase the native HDL pool. The components and design of HDL-based nanoparticles have evolved significantly since their initial introduction with highly anticipated results in an ongoing phase III clinical trial in subjects with acute coronary syndrome. The understanding of mechanisms involved in HDL-based synthetic nanotherapeutics is critical to their design, therapeutic potential and effectiveness. In this review, we provide a current update on HDL-ApoA-I mimetic nanotherapeutics, highlighting the scope of treating vascular diseases by targeting monocytes and macrophages.

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“…Elevation in the triglycerides-high-density lipoprotein cholesterol (TG/HDL-c) ratio can be used as a marker of adiposity and an independent prognostic marker in patients with cardiovascular pathology; it has been shown to be correlated with abdominal obesity and higher body weight in healthy adults [ 121 ], but also with insulin resistance in some populations [ 122 ]. Studies have shown that there is an important correlation between TG/HDL-C ratio, in-hospital mortality, and major adverse cardiac events (MACEs) [ 123 , 124 ]. Patients with PAH usually have a low body mass index (BMI), but recent studies have highlighted elevated levels of circulating lipoproteins in such cases [ 125 ].…”

Section: Metabolic Biomarkersmentioning

confidence: 99%

Biomarkers in Pulmonary Arterial Hypertension

2022

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Pulmonary arterial hypertension (PAH) is a severe medical condition characterized by elevated pulmonary vascular resistance (PVR), right ventricular (RV) failure, and death in the absence of appropriate treatment. The progression and prognosis are strictly related to the etiology, biochemical parameters, and treatment response. The gold-standard test remains right-sided heart catheterization, but dynamic monitoring of systolic pressure in the pulmonary artery is performed using echocardiography. However, simple and easily accessible non-invasive assays are also required in order to monitor this pathology. In addition, research in this area is in continuous development. In recent years, more and more biomarkers have been studied and included in clinical guidelines. These biomarkers can be categorized based on their associations with inflammation, endothelial cell dysfunction, cardiac fibrosis, oxidative stress, and metabolic disorders. Moreover, biomarkers can be easily detected in blood and urine and correlated with disease severity, playing an important role in diagnosis, prognosis, and disease progression.

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TG/HDL-C ratio predicts in-hospital mortality in patients with acute type A aortic dissection

Cited by 7 publications

References 34 publications

Impact of body mass index on perioperative mortality of acute stanford type A aortic dissection: a systematic review and meta-analysis

Impact of body mass index on perioperative mortality of acute stanford type A aortic dissection: a systematic review and meta-analysis

A Current Update on the Role of HDL-Based Nanomedicine in Targeting Macrophages in Cardiovascular Disease

Biomarkers in Pulmonary Arterial Hypertension

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