TFIIH: A Transcription Factor Involved in DNA Repair and Cell-Cycle Regulation

Moncollin, Vincent; Vichi, Paul; Egly, Jean‐Marc

doi:10.1385/0-89603-500-x:143

Cited by 4 publications

(3 citation statements)

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“…The in vivo activating kinase for human CDK7 phosphorylation is still unknown, but in vitro however active phospho-CDK2/cyclin A can phosphorylate CDK7 [ 72 ]. CDK7 also plays an important role in the DNA repair process [ 73 ].…”

Section: Cyclin-dependent Kinases (Cdks)mentioning

confidence: 99%

Cyclin-Dependent Kinases (CDK) and Their Role in Diseases Development–Review

Łukasik

Załuski

Gutowska

2021

IJMS

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Cyclin-dependent kinases (CDKs) are involved in many crucial processes, such as cell cycle and transcription, as well as communication, metabolism, and apoptosis. The kinases are organized in a pathway to ensure that, during cell division, each cell accurately replicates its DNA, and ensure its segregation equally between the two daughter cells. Deregulation of any of the stages of the cell cycle or transcription leads to apoptosis but, if uncorrected, can result in a series of diseases, such as cancer, neurodegenerative diseases (Alzheimer’s or Parkinson’s disease), and stroke. This review presents the current state of knowledge about the characteristics of cyclin-dependent kinases as potential pharmacological targets.

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Section: Cyclin-dependent Kinases (Cdks)mentioning

confidence: 99%

Cyclin-Dependent Kinases (CDK) and Their Role in Diseases Development–Review

Łukasik

Załuski

Gutowska

2021

IJMS

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“…Mutations in the XPD gene can completely prevent DNA opening and dual incision, steps that lead to the repair of DNA adducts (22). The DNA repair function of XPD is critical to reparation of genetic damage from tobacco and other carcinogens (23). Several common single bp substitution polymorphisms in the XPD gene have been identified.…”

Section: Introductionmentioning

confidence: 99%

DNA Repair Gene XRCC1 and XPD Polymorphisms and Risk of Prostate Cancer

Rybicki

Conti

Moreira

et al. 2004

Cancer Epidemiology, Biomarkers &Amp; Prevention

123

111

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The X-ray repair cross-complementing group 1 (XRCC1) and xeroderma pigmentosum group D (XPD) genes are involved in base excision repair and nucleotide excision repair of DNA repair pathways, respectively. A growing body of evidence suggests that XRCC1 and XPD are important in environmentally induced cancers, and polymorphisms in both genes have been identified. To determine whether the XRCC1 (codon Arg399Gln) and XPD (codon Asp312Asn and codon Lys751Gln) polymorphisms are associated with prostate cancer susceptibility, we genotyped these polymorphisms in a primarily Caucasian sample of 506 sibships (n ‫؍‬ 1,117) ascertained through a brother with prostate cancer. Sibships were analyzed with a Cox proportional hazards model with age at prostate cancer diagnosis as the outcome. Of the three polymorphisms investigated, only the XPD codon 312 Asn/Asn genotype had an odds ratio (OR) significantly different from one (OR, 1.61; 95% CI, 1.03-2.53). Analyses stratified by the clinical characteristics of affected brothers in the sibship did not reveal any significant heterogeneity in risk. In exploring two-way gene interactions, we found a markedly elevated risk for the combination of the XPD codon 312 Asn/Asn and XRCC1 codon 399 Gln/Gln genotypes (OR, 4.81; 95% CI, 1.66 -13.97). In summary, our results suggest that the XPD codon 312 Asn allele may exert a modest positive effect on prostate cancer risk when two copies of the allele are present, and this effect is enhanced by the XRCC codon 399 Gln allele in its recessive state.

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“…TFIIH was the first of the basal transcription factors shown to play a role in cellular activities other than expression of protein‐coding genes (reviewed in Hoeijmakers et al ., 1996; Moncollin et al ., 1997). This may be attributed in part to its multisubunit composition of at least nine peptides, XPB, XPD, p62, p52, p44, cdk7, cyclin H, p34 and MAT1.…”

Section: Introductionmentioning

confidence: 99%

Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH

1997

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; Serizawa et al., 1995) CAK et al., 1996), and together they form the CAK responsible (rCAK) produced in insect cells exhibit a strong preferfor activating cdk1, cdk2 and cdk4 (reviewed in Nigg, ence for the cyclin-dependent kinase 2 (cdk2) over a 1996). Serizawa et al., 1992). This subcomplexes in which XPD is found associated with phylogenetically highly conserved domain consists of a either the kinase complex or with the core TFIIH.heptapeptide sequence (YSPTSPS) tandemly repeated up Using these fractions, we demonstrate that TFIIH to 52 times. Phosphorylation of the CTD initiates promoter lacking the CAK subcomplex completely recovers its clearance and transcription elongation (Goodrich and transcriptional activity in the presence of free CAK. Dahmus, 1995). This includes the dissociation Furthermore, studies examining the interactions of pre-initiation complex proteins. The fact that both the between TFIIH subunits provide evidence that CAK TATA-binding protein (TBP) and TFIIE (Usheva et al., is integrated within TFIIH via XPB and XPD.1992; Maxon et al., 1994) interact with the non-phosKeywords: CAK/cdk7/CTD kinase/TFIIH/transcription phorylated but not with the phosphorylated form of the RNA pol II supports this idea. The cdk7 kinase can phosphorylate a synthetic ctd oligopeptide and is therefore thought to be the kinase responsible

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TFIIH: A Transcription Factor Involved in DNA Repair and Cell-Cycle Regulation

Cited by 4 publications

References 0 publications

Cyclin-Dependent Kinases (CDK) and Their Role in Diseases Development–Review

Cyclin-Dependent Kinases (CDK) and Their Role in Diseases Development–Review

DNA Repair Gene XRCC1 and XPD Polymorphisms and Risk of Prostate Cancer

Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH

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