TFA-Protected α-Amino Acid N-Hydroxysuccinimide Ester: Application for Inter- and Intramolecular Acylation

Hashimoto, Makoto; Tachrim, Zetryana Puteri; Oida, Kazuhiro; Ohashi, Fumina; Wakasa, Haruna; Ikemoto, Haruka; Kurokawa, Natsumi; Sakihama, Yasuko; Hashidoko, Yasuyuki; Suzuki, Takayoshi

doi:10.3987/com-18-s(t)65

HETEROCYCLES

2018

DOI: 10.3987/com-18-s(t)65

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TFA-Protected α-Amino Acid N-Hydroxysuccinimide Ester: Application for Inter- and Intramolecular Acylation

Makoto Hashimoto¹,

Zetryana Puteri Tachrim²,

Kazuhiro Oida³

et al.

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2022

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Novel Synthesis and Properties of Optically Pure N-Trifluoroacetylphenylglycine Hydroxysuccinimide Ester

Hashimoto,

Wang,

Ishikawa

et al. 2022

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Phenylglycine is non-proteinogenic α-amino acid, and its partial structure is found in some biologically active compounds. C-Terminal modification of N-acyl-protected phenylglycine sometimes causes racemization due to the fact that the phenyl ring is directly connected to the α-position of the α-amino acid skeleton. In this report, synthesis and the properties of N-trifluoroacetylphenylglycine hydroxysuccinimide ester are described.

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Novel Synthesis and Properties of Optically Pure N-Trifluoroacetylphenylglycine Hydroxysuccinimide Ester

Hashimoto,

Wang,

Ishikawa

et al. 2022

HETEROCYCLES

Self Cite

View full text Add to dashboard Cite

show abstract

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TFA-Protected α-Amino Acid N-Hydroxysuccinimide Ester: Application for Inter- and Intramolecular Acylation

Cited by 1 publication

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Novel Synthesis and Properties of Optically Pure N-Trifluoroacetylphenylglycine Hydroxysuccinimide Ester

Novel Synthesis and Properties of Optically Pure N-Trifluoroacetylphenylglycine Hydroxysuccinimide Ester

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