The regional wheat trials are used to objectively, fairly, and scientifically evaluate the yield and other characteristics of new wheat varieties grown in different wheat regions, and provide important scientific basis for the validation, ecological zoning, species distribution, and rational use of wheat varieties. It can accelerate the promotion of new wheat varieties. The evaluation of regional trial results is of great significance for further improving the scientificity and accuracy of the species trial. Grey statistical decision-making of grey system theory can fully weigh the trial results in different places and make a reasonable assessment of wheat varieties. In this paper, the method used to estimate the regional wheat trials yield is proposed, and 12 varieties of wheat varieties were evaluated with examples. The results were credible. Grey statistical Decisionmaking assessment method for the regional trial yield of wheat varieties proposed in this paper provides a practical method for the evaluation of regional wheat trial.