These papers have been reviewed and accepted for presentation at the conference and for publication in the Journal of Intelligent & Fuzzy Systems (JIFS). In this special issue there are 50 papers covering a wide range of tools, techniques and applications of artificial intelligent techniques and applications. The International conference on Intelligent Systems Technologies and Applications aims to bring together researchers in related fields to explore and discuss various aspects of intelligent systems technologies and their applications. It provides excellent opportunities for the presentation of interesting new research results and discussion about them,