We report a joint experimental and theoretical study of the structural, vibrational, elastic, optical and electronic properties of the layered high-mobility semiconductor Bi 2 O 2 Se at high pressure. A good agreement between experiments and ab initio calculations is observed for the equation of state, the pressure coefficients of the Raman-active modes and the bandgap of the material. In particular, a detailed description of the vibrational properties is provided. Unlike other Sillén-type compounds which undergo a tetragonal to collapsed tetragonal pressure-induced phase transition at relatively low pressures, Bi 2 O 2 Se shows a remarkable structural stability up to 30 GPa; however, our results indicate that this compound exhibits considerable electronic changes around 4 GPa, likely related to the progressive shortening and hardening of the long and weak Bi-Se bonds linking the Bi 2 O 2 and Se atomic layers. Variations of the structural, vibrational, and electronic properties induced by these electronic changes are discussed.