Texosome-anchored superantigen triggers apoptosis in original ovarian cancer cells

Hosseini, Hamideh Mahmoodzadeh; Soleimanirad, Jafar; Aghdam, Elnaz Mehdizadeh; Amin, Mohsen; Fooladi, Abbas Ali Imani

doi:10.1007/s12032-014-0409-6

Cited by 15 publications

(3 citation statements)

References 22 publications

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“…To measure the density of amplicons, each PCR product was run on 2% agarose gel electrophoresis, stained by ethidium bromide and visualized under UV gel document. Finally, the density of each product band was measured by Image J ( Hillmann, Ramdas, Multanen, Norman, & Harmon, 2000 ; Mahmoodzadeh Hosseini, Soleimanirad, Mehdizadeh Aghdam, Amin, & Fooladi, 2015 ).…”

Section: Methodsmentioning

confidence: 99%

Effects of the Extremely Low Frequency Electromagnetic Fields on NMDA-Receptor Gene Expression and Visual Working Memory in Male Rhesus Macaques

Kazemi

Sahraei

Aliyari

et al. 2018

BCN

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Introduction:The present research aimed to examine Visual Working Memory (VWM) test scores, as well as hormonal, genomic, and brain anatomic changes in the male rhesus macaques exposed to Extremely Low Frequency Magnetic Field (ELF-MF).Methods:Four monkeys were exposed to two different ELF-MF frequencies: 1 Hz (control) and 12 Hz (experiment) with 0.7 μT (magnitude) 4 h/d for 30 consecutive days. Before and after the exposure, VWM test was conducted using a coated devise on a movable stand. About 10 mL of the animals’ blood was obtained from their femoral vain and used to evaluate their melatonin concentration. Blood lymphocytes were used for assaying the expressions of N-Methyl-D-aspartate NMDA-receptor genes expression before and after ELF exposure. Anatomical changes of hippocampus size were also assessed using MRI images.Results:Results indicated that VWM scores in primates exposed to 12 Hz frequency ELF increased significantly. Plasma melatonin level was also increased in these animals. However, these variables did not change in the animals exposed to 1 Hz ELF. At last, expression of the NMDA receptors increased at exposure to 12 Hz frequency. However, hippocampal volume did not increase significantly in the animals exposed to both frequencies.Conclusion:In short, these results indicate that ELF (12 Hz) may have a beneficial value for memory enhancement (indicated by the increase in VWM scores). This may be due to an increase in plasma melatonin and or expression of NMDA glutamate receptors. However, direct involvement of the hippocampus in this process needs more research.

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Section: Methodsmentioning

confidence: 99%

Effects of the Extremely Low Frequency Electromagnetic Fields on NMDA-Receptor Gene Expression and Visual Working Memory in Male Rhesus Macaques

Kazemi

Sahraei

Aliyari

et al. 2018

BCN

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“…IRGD exosomes armed with adriamycin (Dox) were administered to animals with ovarian tumors causing a reduction in the tumor volume [ 118 ]. Similarly, tumor-derived exosomes (TEX) loaded with staphylococcal enterotoxin B (SEB) have cytotoxic effects on ovaria tumor cell SKOV3 with remarkably reduced tumor growth and increased programmed cell death [ 119 ].…”

Section: Exosomes and Breast Cancermentioning

confidence: 99%

Exosome-Mediated Therapeutic Strategies for Management of Solid and Hematological Malignancies

Allegra

Petrarca

Gioacchino

et al. 2022

Cells

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Exosomes are small membrane vesicles of endocytic origin containing cytokines, RNAs, growth factors, proteins, lipids, and metabolites. They have been identified as fundamental intercellular communication controllers in several diseases and an enormous volume of data confirmed that exosomes could either sustain or inhibit tumor onset and diffusion in diverse solid and hematological malignancies by paracrine signaling. Thus, exosomes might constitute a promising cell-free tumor treatment alternative. This review focuses on the effects of exosomes in the treatment of tumors, by discussing the most recent and promising data from in vitro and experimental in vivo studies and the few existing clinical trials. Exosomes are extremely promising as transporters of drugs, antagomir, genes, and other therapeutic substances that can be integrated into their core via different procedures. Moreover, exosomes can augment or inhibit non-coding RNAs, change the metabolism of cancer cells, and modify the function of immunologic effectors thus modifying the tumor microenvironment transforming it from pro-tumor to antitumor milieu. Here, we report the development of currently realized exosome modifiers that offer indications for the forthcoming elaboration of other more effective methods capable of enhancing the activity of the exosomes.

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“…Results showed that the proliferation was significantly inhibited and the apoptosis rate was increased in SKOV3 treated with TEX-SEB, indicating that exosome reconstruction can be a potential therapeutic method for ovarian cancer. 112 Additionally, exosomes can carry molecules involved in antigen presentation, such as MHCI, HSP, tumor-associated antigens (ie, ovarian cancer antigens MAGE, NY-ESO, P53, Muc-1), indicating its immunotherapeutic prospects. 72 , 77 , 113 For example, Andre et al found that exosomes isolated from malignant ascites constituted a source of tumor antigens that could be transferred to DCs and then the DCs caused differentiation and expansion of tumor-specific cytotoxic T lymphocytes, leading to anti-tumor response.…”

Section: Introductionmentioning

confidence: 99%

Advances of exosome in the development of ovarian cancer and its diagnostic and therapeutic prospect

Shen

Zhu

Jing

et al. 2018

OTT

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Ovarian cancer is the leading cause of female gynecological cancer mortality. Most patients with ovarian cancer are diagnosed with advanced stage because of lack of early symptoms, physical signs, and sensitive tumor biomarkers. The standard treatment includes cytoreductive surgery and platinum-based chemotherapy (usually platinum combined with paclitaxel). Despite that postoperative adjuvant chemotherapy prolongs survival time, most patients go through relapse within 6–12 months after the treatment. Thus, elucidating the molecular mechanism in cancer development is essential to promote early diagnosis and novel treatments. The role of exosome has been highlighted in multiple research fields in recent years. Exosome has been described as nano-sized vesicle secreted by multiple mammalian cell types, carrying cargos like proteins, miRNAs, mRNAs, and lipids. It participates in the formation of tumor microenvironment and the development of tumorigenesis and drug resistance in ovarian cancer. Meanwhile, it may also play a pivotal role in diagnosis, efficacy evaluation, and prognosis. Besides, studies show that exosome and its processed products have promising value in ovarian cancer treatment. The aim of the current review is to describe the characteristics of exosome in ovarian cancer, especially focusing on its role in immune modulation and drug resistance, hoping to provide new information on its implications in cancer diagnosis and treatment.

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Texosome-anchored superantigen triggers apoptosis in original ovarian cancer cells

Cited by 15 publications

References 22 publications

Effects of the Extremely Low Frequency Electromagnetic Fields on NMDA-Receptor Gene Expression and Visual Working Memory in Male Rhesus Macaques

Effects of the Extremely Low Frequency Electromagnetic Fields on NMDA-Receptor Gene Expression and Visual Working Memory in Male Rhesus Macaques

Exosome-Mediated Therapeutic Strategies for Management of Solid and Hematological Malignancies

Advances of exosome in the development of ovarian cancer and its diagnostic and therapeutic prospect

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