Tetrazole Derivatives (Preparation, Organic Analysis, Biotic Evaluation, Nano-Study

Abstract

Micro-organisms are the causes of many diseases, so we find a lot of research in the field of studying the biological efficacy of compounds on various types of pathogenic bacteria. Nowadays there are increasing numbers of infections caused by bacteria that are resistant to most of the antibacterial treatments currently available, for this causes we prepared series tetrazole derivative from different heterocyclic compounds like (tetrazole, thiadiazole, oxadiazole, oxazole, imidazole, triazole, thiazole . General studies have been steered for the derivatives to conclude their chemical configurations via spectroscopic performances (FT.IR, H.NMR, Mass)-spectra, also Biotic Evaluation, Nano-study and other laboratory measurements. Some cyclic compounds are used as antimicrobials, and this is what we have proven in our research, as it has been proven that they are compounds that kill microorganisms or stop their growth. Antimicrobial drugs can be divided according to the microorganisms that they can work against. For example, antibiotics are used against bacteria and antifungals are used against fungi.

Conformational Properties of New Thiosemicarbazone and Thiocarbohydrazone Derivatives and Their Possible Targets

“…Chalcone A was obtained using Claisen-Schmidt aldolic condensation and standard conditions [27]. Briefly, 55 mmoles of NaOH were dissolved in 95% EtOH/H 2 O 1:1 (250 mL), then 50 mmoles of acetophenone were added, and the mixture was cooled to 0 • C. Benzaldehyde, 50 mmoles, dissolved in 95% EtOH (50 mL), was added dropwise, and the reaction mixture was left to reach room temperature gradually for 24 h. The solid formed was filtered, washed with 95% EtOH/H 2 O 1:1, and used for the next preparations after drying in a desiccator over P 2 O 5 .…”

“…Chalcone A was obtained using Claisen-Schmidt aldolic condensation and standard conditions [27]. Briefly, 55 mmoles of NaOH were dissolved in 95% EtOH/H2O 1:1 (250 mL), then 50 mmoles of acetophenone were added, and the mixture was cooled to 0 °C.…”

Synthesis and Characterization of some new heterocyclic derivatives from aromatic carbonyl ‎compounds and carboxylic acids with Evaluation some of them for biological activity

“…Tetrazole synthesis requires the cyclization of thiosemicarbazide under strong initial conditions. Furthermore, oxadiazole and β-lactam can be synthesized via different literature methods [26][27][28][29][30][31].…”

Pyrimidine-Sulphone Ligands (Formation, Characterization, Bio Evaluation) as Bio-Compounds

“…In reducing the spread of breast cancer in mice., The pyrimidine substitutes have similar efficacy to the pharmaceutical-pharmaceutical compounds [21][22][23][24][25][26][27] used in the treatment of ulcers and infections, nerve paralysis, ulcers, and they are also used as lipid oxidation inhibitors in experiments conducted on rats. The pyrimidine substitutes are effective in the industrial field [28][29][30][31][32]. Pyrimidine derivatives have been used in the manufacture of dyes for fabrics that contain nylon to give colors [33][34][35][36][37] between yellow and coffee.…”