Tetrazole-based inhibitors of the bacterial enzyme N-succinyl-l,l-2,6-diaminopimelic acid desuccinylase as potential antibiotics

Synthesis of a novel fused thieno‐pyrimidine with tetrazole analogs

“…Moreover, tetrazoles and their derivatives have been found to have a variety of biological properties, including the ability to reduce hypertension [21], fight cancer [22], inhibit fungal growth [23], reduce inflammation [24], and produce explosive effects [25]. A thorough investigation has been conducted on this structural framework which consists of one carbon atom and four nitrogen atoms [26]. Tetrazole hybrids' possible anticancer effect was discovered by a thorough analysis of their structure-activity relationship [20].…”