Tetrazine bioorthogonal chemistry makes nanotechnology a powerful toolbox for biological applications

Zhang, Renshuai; Gao, Jiake; Zhao, Guiqiu; Zhou, Li-Man; Kong, Fandong; Jiang, Tao; Jiang, Hongfei

doi:10.1039/d2nr06056f

Cited by 10 publications

(2 citation statements)

References 68 publications

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“…Interestingly, dual-responsive CPT nanoprodrugs relying on the promising inverse electron-demand Diels-Alder (iEDDA) ligation, a powerful toolbox which won the 2022 Nobel Prize in Chemistry, 166,246 have been developed for tumor theranostics. 247 This study combined cathepsin B and low pH dualstimulus-responsive nanocarriers, including tetrazine-masked aza-dipyrromethene boron difluoride (BOD) fluorescent probe (TZ-BOD) and vinyl ether-masked CPT (VE-CPT) nanoprodrugs, for the bioorthogonal reaction (among the tetrazine group of TZ-BOD and the vinyloxy group of VE-CPT)-activated tumor treatment (Fig.…”

Section: Dual-and Multi-responsive Cpt Prodrug Nanomedicinesmentioning

confidence: 99%

Camptothecin-based prodrug nanomedicines for cancer therapy

Zhang,

Yu,

Guo

et al. 2023

Nanoscale

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Section: Dual-and Multi-responsive Cpt Prodrug Nanomedicinesmentioning

confidence: 99%

Camptothecin-based prodrug nanomedicines for cancer therapy

Zhang,

Yu,

Guo

et al. 2023

Nanoscale

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“…Over the years, researchers have mitigated these issues by developing a variety of pH-sensitive or responsive nanomaterials (NMs), including inorganic, organic, and hybrids, targeting live pH for cell organellespecific localization monitoring [61,63,69,70]. Based on these NMs, various strategies are employed to construct pH-responsive biosensors to capably distinguish the different acidic divisions in cell organelles, such as early endosomes (pH 6.0−6.5) and lysosomes (pH 4.5−5.5) [53,[71][72][73][74][75][76][77][78][79][80][81][82][83][84][85][86][87].…”

Section: Intracellular/ Extracellular Ph Sensingmentioning

confidence: 99%

pH Monitoring in Biological Environment: An Overview of Conventional to Cutting-Edge Sensing Platforms

Akhtar¹,

Nawaz²,

Liu³

et al. 2023

Preprint

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pH is considered one of the paramount factors in bodily functions, because most of the cellular tasks exclusively rely on precise pH values. The regulation of pH is a necessary feature of the intracellular atmosphere and can be established as a strong indicator to judge a physiological abnormality in most of the cases. In this context, the current techniques for pH sensing provide us with the futuristic insight to further design therapeutic and diagnostic tools. Thus, pH-sensing (electrochemically and optically) is rapidly evolving toward exciting new applications and expanding researchers’ interests in many chemical contexts, especially in biomedical applications. The adaptation of cutting-edge technology is subsequently producing the modest form of these biosensors as wearable devices, which are providing us the opportunity to target the real-time collection of vital parameters, including pH for improved healthcare systems. The motif of this review is to provide an insight of trending tech-based systems employed in real time or in-vivo pH responsive monitoring. Herein, we briefly go through the pH regulation in the human body to help the beginners and scientific community with quick background knowledge, recent advances in the field, and pH detection in cancerous environments. In the end, we summarize our review by providing an outlook; challenges that need to be addressed and prospective integration of various pH in vivo platforms with modern electronics that can open new avenues of cutting-edge techniques for disease diagnostics and prevention.

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Bioconjugation in Materials Science

Bednarek

Schepers

Thomas

et al. 2023

Adv Funct Materials

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With the advent of bioconjugation chemistry in the last two decades, highlighted by the Nobel Prize 2022, the quest for possible novel applications has been greatly intensified, broadening the prospects of these mostly simple, specific, and high‐yield reactions. The advancement of bioconjugation methods is anticipated to expand the scope of bioinstructive and bioadaptive materials science in the future. This perspective article will discuss the reactions developed in this research area over the last 10 years for coupling various biological entities such as polysaccharides, oligonucleotides, peptides, and proteins. Building on this, the impact of bioconjugation reactions in materials science and 3D printing, including their challenges and requirements is shown. Established procedures for modifying molecular structures such as Covalent and Metal Organic Frameworks (COF/MOF) or hybrid materials for biomedical applications and the scope for future research and optimization will be presented.

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Tetrazine bioorthogonal chemistry makes nanotechnology a powerful toolbox for biological applications

Abstract: Bioorthogonal chemistry enables researchist to manipulate bioactive molecules in living systems. These highly selective and biocompatible reactions can be carried out in various complex environments. Over the past two decades,...

Cited by 10 publications

References 68 publications

Camptothecin-based prodrug nanomedicines for cancer therapy

Camptothecin-based prodrug nanomedicines for cancer therapy

pH Monitoring in Biological Environment: An Overview of Conventional to Cutting-Edge Sensing Platforms

Bioconjugation in Materials Science

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