Tetrazine-Based Ratiometric Nitric Oxide Sensor Identifies Endogenous Nitric Oxide in Atherosclerosis Plaques by Riding Macrophages as a Smart Vehicle

Stimuli-responsive polymer-based nanosystems for cardiovascular disease theranostics

“…Polymer-based nanosystems have been extensively utilized as a detection platform for biosensors owing to their exceptional sensitivity, selectivity, and response capabilities. 137–143 Without any doubt, polymer-based biosensors can be specifically employed for the detection of ROS, cardiac troponin I (cTnI), pH levels, phosphorylation events, and glucose. For example, Zhang et al reported the utilization of ratiometric semiconducting polymer nanoparticles (RSPN) for detecting reactive oxygen species (ROS) and assessing oxidative stress within atherosclerotic lesions using photoacoustic imaging (Fig.…”

Anti-cancer drug axitinib: a unique tautomerism-induced dual-emissive probe for protein analysis

“…In contrast, fluorescence-based analytical methods have emerged as promising alternatives for detecting HSA due to their simplified procedures, rapid response times, and enhanced selectivity. 7–25 However, most reported probes enable HSA detection based on changes in a single emission peak, which can be easily influenced by variations in analyte-independent factors, such as excitation source, photobleaching, and probe concentration. 26–28 Alternatively, a ratiometric fluorescent probe can provide a response signal dependent on the ratio of two emissions, rather than relying solely on a single emission.…”